Adam Corrigan
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View article: Hit screening with multivariate robust outlier detection
Hit screening with multivariate robust outlier detection Open
Hit screening, which involves the identification of compounds or targets capable of modulating disease-relevant processes, is an important step in drug discovery. Some assays, such as image-based high-content screenings, produce complex mu…
View article: CLANet: A comprehensive framework for cross-batch cell line identification using brightfield images
CLANet: A comprehensive framework for cross-batch cell line identification using brightfield images Open
Cell line authentication plays a crucial role in the biomedical field, ensuring researchers work with accurately identified cells. Supervised deep learning has made remarkable strides in cell line identification by studying cell morphologi…
View article: Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System
Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System Open
The function of the glomerulus depends on the complex cell–cell/matrix interactions and replication of this in vitro would aid biological understanding in both health and disease. Previous models do not fully reflect all cell types and int…
View article: CLANet: A Comprehensive Framework for Cross-Batch Cell Line Identification Using Brightfield Images
CLANet: A Comprehensive Framework for Cross-Batch Cell Line Identification Using Brightfield Images Open
Cell line authentication plays a crucial role in the biomedical field, ensuring researchers work with accurately identified cells. Supervised deep learning has made remarkable strides in cell line identification by studying cell morphologi…
View article: Nuclear fascin regulates cancer cell survival
Nuclear fascin regulates cancer cell survival Open
Fascin is an important regulator of F-actin bundling leading to enhanced filopodia assembly. Fascin is also overexpressed in most solid tumours where it supports invasion through control of F-actin structures at the periphery and nuclear e…
View article: Author response: Nuclear fascin regulates cancer cell survival
Author response: Nuclear fascin regulates cancer cell survival Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Fascin is an important…
View article: Nuclear fascin regulates cancer cell survival
Nuclear fascin regulates cancer cell survival Open
Fascin is an important regulator of F-actin bundling leading to enhanced filopodia assembly. Fascin is also overexpressed in most solid tumours where it supports invasion through control of F-actin structures at the periphery and nuclear e…
View article: An automated cell line authentication method for AstraZeneca global cell bank using deep neural networks on brightfield images
An automated cell line authentication method for AstraZeneca global cell bank using deep neural networks on brightfield images Open
Cell line authentication is important in the biomedical field to ensure that researchers are not working with misidentified cells. Short tandem repeat is the gold standard method, but has its own limitations, including being expensive and …
View article: An Automated Cell Line Authentication Method for AstraZeneca Global Cell Bank using Deep Neural Networks on Brightfield Images
An Automated Cell Line Authentication Method for AstraZeneca Global Cell Bank using Deep Neural Networks on Brightfield Images Open
Cell line authentication is important in the biomedical field to ensure that researchers are not working with misidentified cells. Short tandem repeat is the gold standard method, but has its own limitations, including being expensive and …
View article: Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens Open
Genome-wide arrayed CRISPR screening is a powerful method for drug target identification as it enables exploration of the effect of individual gene perturbations using diverse highly multiplexed functional and phenotypic assays. Using high…
View article: IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate
IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate Open
This work presents a MATLAB-based software package for high-throughput microscopy image analysis development, making such development more accessible for a large user community. The toolbox provides a GUI and a number of analysis workflows…
View article: Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication
Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication Open
Significance Gene transcription occurs in discontinuous bursts. Although bursts are conserved in all forms of life, the causes and implications of bursting are not clear. Here we delineate a specific cause of bursts and contextualize the s…
View article: Two-step interphase microtubule disassembly aids spindle morphogenesis
Two-step interphase microtubule disassembly aids spindle morphogenesis Open
Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase microtubule disassembly. First, a…
View article: A continuum model of transcriptional bursting
A continuum model of transcriptional bursting Open
Transcription occurs in stochastic bursts. Early models based upon RNA hybridisation studies suggest bursting dynamics arise from alternating inactive and permissive states. Here we investigate bursting mechanism in live cells by quantitat…
View article: Author response: A continuum model of transcriptional bursting
Author response: A continuum model of transcriptional bursting Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Supplementary experimental procedures Appendix 2 in silico dynamic transcription framework Appendix 3 Stochastic theory of tran…
View article: Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity
Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity Open
Much of development and disease concerns the generation of gene expression differences between related cells sharing similar niches. However most analyses of gene expression only assess population and time-averaged levels of steady-state t…