Adam D. Bachstetter
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View article: Pancreatic hypersecretion of amyloid-forming human amylin dysregulates the neuro-immune axis and B cell development in a model of type-2 diabetes
Pancreatic hypersecretion of amyloid-forming human amylin dysregulates the neuro-immune axis and B cell development in a model of type-2 diabetes Open
View article: Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice
Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice Open
Artificial light at night (light pollution) is widespread but understudied in the context of Alzheimer's disease (AD). Sleep and circadian disruption have been linked to amyloid-β (Aβ) accumulation and neuroinflammation, but whether dim li…
View article: Traumatic brain injury exacerbates mitochondrial dysfunction in APP/PS1 knock-in mice through time-dependent pathways
Traumatic brain injury exacerbates mitochondrial dysfunction in APP/PS1 knock-in mice through time-dependent pathways Open
Cerebral hypometabolism occurs in both traumatic brain injury (TBI) and Alzheimer’s disease (AD), but whether these conditions act through distinct or overlapping mechanisms is unclear. TBI disrupts cerebral metabolism via blood–brain barr…
View article: Chronic Sleep Fragmentation Differentially Affects Alzheimer’s Disease Pathology in Male and Female APPSAA Knock-in Mice
Chronic Sleep Fragmentation Differentially Affects Alzheimer’s Disease Pathology in Male and Female APPSAA Knock-in Mice Open
Chronic sleep fragmentation exacerbates AD-related pathology in APPSAA mice in a sex-dependent manner, with females showing greater vulnerability to Aβ accumulation and astrocyte reactivity following sleep disruption. These find…
View article: Temporal immune profiling in the cerebrospinal fluid and blood of patients with aneurysmal subarachnoid hemorrhage
Temporal immune profiling in the cerebrospinal fluid and blood of patients with aneurysmal subarachnoid hemorrhage Open
Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. Twelve aSAH patients were enrolled.…
View article: Assessing Co‐Localization of <scp>ITM2B</scp> With Alzheimer's Disease and Limbic‐Predominant Age‐Related <scp>TDP</scp>‐43 Encephalopathy Neuropathologic Changes
Assessing Co‐Localization of <span>ITM2B</span> With Alzheimer's Disease and Limbic‐Predominant Age‐Related <span>TDP</span>‐43 Encephalopathy Neuropathologic Changes Open
Mutations in the Integral membrane protein 2B ( ITM2B ) gene are linked to the development of familial British and Danish dementias, two relatively early‐onset dementia disorders known also to be associated with Tau neurofibrillary tangles…
View article: Alzheimer’s disease and the immune system: the emerging role of TEMRA cells
Alzheimer’s disease and the immune system: the emerging role of TEMRA cells Open
View article: Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage
Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage Open
Background: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. Methods: Twelve aSAH pa…
View article: Exploring the link between dystrophic microglia and the spread of Alzheimer's neuropathology
Exploring the link between dystrophic microglia and the spread of Alzheimer's neuropathology Open
Genetics and other data modalities indicate that microglia play a critical role in Alzheimer's disease progression, but details of the disease-driving influence of microglia are poorly understood. Microglial cells can be parsed into subtyp…
View article: A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC
A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC Open
View article: Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort Open
Background and purpose The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T EMRA ) are important during aging and …
View article: Old Age Exacerbates White Matter Neuroinflammation and Cognitive Deficits Following Closed-Head Injury, Particularly in Female Mice
Old Age Exacerbates White Matter Neuroinflammation and Cognitive Deficits Following Closed-Head Injury, Particularly in Female Mice Open
The increasing incidence of traumatic brain injury (TBI) among older adults, particularly mild injuries from falls, underscores the need to investigate age-related outcomes and potential sex differences in response to TBI. Although previou…
View article: Sex-Biased Expression and Response of microRNAs in Neurological Diseases and Neurotrauma
Sex-Biased Expression and Response of microRNAs in Neurological Diseases and Neurotrauma Open
Neurological diseases and neurotrauma manifest significant sex differences in prevalence, progression, outcome, and therapeutic responses. Genetic predisposition, sex hormones, inflammation, and environmental exposures are among many physi…
View article: Sex differences in baseline sleep and dark phase rebound sleep after chronic sleep fragmentation in the APPXPS1 and 5XFAD mouse models
Sex differences in baseline sleep and dark phase rebound sleep after chronic sleep fragmentation in the APPXPS1 and 5XFAD mouse models Open
Background Fragmentation of the daily sleep‐wake rhythm is a risk factor for Alzheimer’s disease (AD) (Li et al, Lancet Healthy Longev 1:e96‐e105 [2020]). While women have a higher AD incidence than men, whether women are more sensitive to…
View article: Emerging role of miR‐223‐3p in regulating sex dimorphic neuroinflammation and cognitive function in mice following controlled cortical impact
Emerging role of miR‐223‐3p in regulating sex dimorphic neuroinflammation and cognitive function in mice following controlled cortical impact Open
Background Neuroinflammation is a key feature of many neurodegenerative diseases, however its regulation is not well understood. MicroRNAs (miRNAs) are small, non‐coding RNAs that involve in the regulation of many biological and pathologic…
View article: Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury Open
View article: Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort Open
Background and Purpose The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T EMRA ) are important during aging and …
View article: IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury Open
View article: A neuropathologic feature of brain aging: multi-lumen vascular profiles
A neuropathologic feature of brain aging: multi-lumen vascular profiles Open
View article: Proinflammatory and Immunomodulatory Gene and Protein Expression Patterns in Spinal Cord and Spleen Following Acute and Chronic High Thoracic Injury
Proinflammatory and Immunomodulatory Gene and Protein Expression Patterns in Spinal Cord and Spleen Following Acute and Chronic High Thoracic Injury Open
Novel temporal-spatial cytokine expression profiles reveal that TNFα protein levels are increased solely in upper thoracic segments after high thoracic SCI, while IFNγ remains unaltered. Splenic leukopenia and latent systemic immunosuppres…
View article: Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury
Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury Open
Spinal cord injury (SCI) is a devastating condition characterized by impaired motor and sensory function, as well as internal organ pathology and dysfunction. This internal organ dysfunction, particularly gastrointestinal (GI) complication…
View article: Editorial: Innate immunity and neurodegenerative diseases – triggers from self and non-self
Editorial: Innate immunity and neurodegenerative diseases – triggers from self and non-self Open
EDITORIAL article Front. Mol. Neurosci., 07 June 2023Sec. Brain Disease Mechanisms Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1227896
View article: 0225 Effect of thermoneutral temperature exposure in the APP/PS1 knock-in mouse model of Alzheimer’s disease
0225 Effect of thermoneutral temperature exposure in the APP/PS1 knock-in mouse model of Alzheimer’s disease Open
Introduction There is growing evidence that disordered sleep in Alzheimer’s disease (AD) may accelerate neuropathology, thus promoting a vicious cycle. In a previous study, we found that improving sleep through thermoneutral ambient temper…
View article: 0094 Effects of Rocking-induced Sleep Enhancement on Wild Type (WT) and APPxPS1 Knock-in (KI) Alzheimer’s Disease (AD) Mice
0094 Effects of Rocking-induced Sleep Enhancement on Wild Type (WT) and APPxPS1 Knock-in (KI) Alzheimer’s Disease (AD) Mice Open
Introduction Passive rhythmic movement–rocking – is found to enhance sleep, particularly in infants and young wild type (WT) mice. Rocking can potentially enhance sleep at all ages, with the added benefit of being non-invasive, easy to tra…
View article: Association between APOE genotype and microglial cell morphology
Association between APOE genotype and microglial cell morphology Open
APOE is the largest genetic risk factor for late-onset Alzheimer disease (AD) with E4 conferring an increased risk for AD compared to E3. The ApoE protein can impact diverse pathways in the brain including neuroinflammation but the precise…
View article: The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER
The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER Open
New histological techniques are needed to examine protein distribution in human tissues, which can reveal cell shape and disease pathology connections. Spatial proteomics has changed the study of tumor microenvironments by identifying spat…
View article: Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia
Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia Open
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors. Purinergic receptor activation gives rise to diverse intracellular calcium (Ca2+ sig…
View article: A blunted TH17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults
A blunted TH17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults Open
People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune …
View article: Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice
Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice Open
Introduction Mild traumatic brain injury (mTBI) has been shown to negatively alter bacterial diversity and composition within the gut, known as dysbiosis, in rodents and humans. These changes cause secondary consequences systemically throu…
View article: Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice Open
Highly reproducible animal models of traumatic brain injury (TBI), with well-defined pathologies, are needed for testing therapeutic interventions and understanding the mechanisms of how a TBI alters brain function. The availability of mul…