Adam D. Wegman
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View article: Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles
Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles Open
Dengue virus (DENV) is a mosquito-borne flavivirus which coexists as four genetically and immunologically distinct serotypes (DENV-1 to -4). In secondary heterologous DENV infection, pre-existing immunity is believed to contribute to sever…
View article: DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection Open
Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest kno…
View article: DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection Open
Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest kno…
View article: Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells
Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells Open
Dengue virus (DENV) is endemic in over 100 countries, infecting an estimated 400 million individuals every year. Infection with DENV raises a significant antibody response, primarily consisting of antibodies targeting viral (structural) pr…
View article: Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection
Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection Open
Dengue virus (DENV) is a prevalent human pathogen, infecting approximately 400 million individuals per year and causing symptomatic disease in approximately 100 million. A distinct feature of dengue is the increased risk for severe disease…
View article: Monomeric IgA antagonizes IgG-mediated enhancement of DENV infection
Monomeric IgA antagonizes IgG-mediated enhancement of DENV infection Open
Dengue virus (DENV) is a prevalent human pathogen, infecting approximately 400 million individuals per year and causing symptomatic disease in approximately 100 million. A distinct feature of dengue is the increased risk for severe disease…
View article: Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity
Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity Open
SARS-CoV-2 represents an unprecedented public health challenge. While the majority of SARS-CoV-2-infected individuals with mild-to-moderate COVID-19 resolve their infection with few complications, some individuals experience prolonged symp…
View article: Persistent COVID-19 symptoms minimally impact the development of SARS-CoV-2 specific cellular immunity
Persistent COVID-19 symptoms minimally impact the development of SARS-CoV-2 specific cellular immunity Open
SARS-CoV-2 represents an unprecedented public health challenge with many unknowns remaining regarding the factors that impact viral pathogenicity and the development of immunity after infection. While the majority of SARS-CoV-2 infected in…
View article: Mobilization and Activation of the Innate Immune Response to Dengue Virus
Mobilization and Activation of the Innate Immune Response to Dengue Virus Open
Dengue virus is an important human pathogen, infecting an estimated 400 million individuals per year and causing symptomatic disease in a subset of approximately 100 million. Much of the effort to date describing the host response to dengu…
View article: 125. Effect of Body Temperature Before Hospital Discharge on the Readmission Rate
125. Effect of Body Temperature Before Hospital Discharge on the Readmission Rate Open
Background One of the goals of the Affordable Care Act is to decrease readmission rates, which lead to wasting of resources and are associated with worse patient outcomes. While widely adhered to, there is no published research to support …
View article: Serum IL-1RA levels increase from follicular to luteal phase of the ovarian cycle: A pilot study on human female immune responses
Serum IL-1RA levels increase from follicular to luteal phase of the ovarian cycle: A pilot study on human female immune responses Open
The immune responses exhibited by females are distinct from those of males. Females are known to generate, among others, higher levels of antibodies, greater interferon responses, and increased levels of inflammatory mediators in response …