Explanipedia

Optical-resolution parallel ultraviolet photoacoustic microscopy for slide-free histology Open

Rui Cao, Yilin Luo, Jingjing Zhao, Yushun Zeng, Yide Zhang , et al. · 2024

Intraoperative imaging of slide-free specimens is crucial for oncology surgeries, allowing surgeons to quickly identify tumor margins for precise surgical guidance. While high-resolution ultraviolet photoacoustic microscopy has been demons…

Noninvasive virtual biopsy using micro-registered optical coherence tomography (OCT) in human subjects Open

Yonatan Winetraub, Aidan Van Vleck, Edwin Yuan, Itamar Terem, Jinjing Zhao , et al. · 2024

Histological hematoxylin and eosin–stained (H&E) tissue sections are used as the gold standard for pathologic detection of cancer, tumor margin detection, and disease diagnosis. Producing H&E sections, however, is invasive and time-consumi…

Visualizing cortical blood perfusion after photothrombotic stroke in vivo by needle-shaped beam optical coherence tomography angiography Open

X. Guo, Jingjing Zhao, Liqun Sun, Varun Gupta, Lin Du , et al. · 2024

Optical imaging techniques provide low-cost, non-radiative images with high spatiotemporal resolution, making them advantageous for long-term dynamic observation of blood perfusion in stroke research and other brain studies compared to non…

Needle-shaped beam optical coherence tomography angiography visualizing cortical blood perfusion after photothrombotic stroke in vivo Open

Yong Huang, X. Guo, Jingjing Zhao, Liqun Sun, Varun Gupta , et al. · 2023

Optical imaging techniques provide low-cost, non-radiative images with high spatiotemporal resolution, making them advantageous for long-term dynamic observation of blood perfusion in stroke research and other brain studies compared to non…

Rapid Cellular-Resolution Skin Imaging with Optical Coherence Tomography Using All-Glass Multifocal Metasurfaces Open

Jingjing Zhao, Aidan Van Vleck, Yonatan Winetraub, Lin Du, Yong Han , et al. · 2023

Cellular-resolution optical coherence tomography (OCT) is a powerful tool offering noninvasive histology-like imaging. However, like other optical microscopy tools, a high numerical aperture (N.A.) lens is required to generate a tight focu…

Optical-resolution photoacoustic microscopy with a needle-shaped beam Open

Rui Cao, Jingjing Zhao, Lei Li, Lin Du, Yide Zhang , et al. · 2022

Intravital 3D visualization and segmentation of murine neural networks at micron resolution Open

Ziv Lautman, Yonatan Winetraub, Eran Blacher, Caroline Yu, Itamar Terem , et al. · 2022

Flexible method for generating needle-shaped beams and its application in optical coherence tomography Open

Jingjing Zhao, Yonatan Winetraub, Lin Du, Aidan Van Vleck, Kenzo Ichimura , et al. · 2022

Needle-shaped beams (NBs) featuring a long depth-of-focus (DOF) can drastically improve the resolution of microscopy systems. However, thus far, the implementation of a specific NB has been onerous due to the lack of a common, flexible gen…

Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography Open

Pelham Keahey, Peng Si, Mohammad S. Razavi, Shang‐Jie Yu, Norman Lippok , et al. · 2021

Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's struc…

OCT2Hist: Non-Invasive Virtual Biopsy Using Optical Coherence Tomography Open

Yonatan Winetraub, Edwin Yuan, Itamar Terem, Caroline Yu, Warren Chan , et al. · 2021

Histological haematoxylin and eosin–stained (H&E) tissue sections are used as the gold standard for pathologic detection of cancer, tumour margin detection, and disease diagnosis 1 . Producing H&E sections, however, is invasive and time-co…

Gold nanomaterials for optical biosensing and bioimaging Open

Peng Si, Nasrin Razmi, Omer Nur, Shipra Solanki, Chandra Mouli Pandey , et al. · 2021

In this minireview, we discuss the emerging optical biosensing and bioimaging techniques that leverage the unique optical properties of gold nanoparticles.

Gold nanoparticles to enhance ophthalmic imaging Open

Fang Chen, Peng Si, Adam de la Zerda, Jesse V. Jokerst, David Myung · 2020

Gold nanoparticles are promising OCT and PAI contrast agents for ophthalmic imaging because of their high light scattering/absorption from SPR.

Angular compounding for speckle reduction in optical coherence tomography using geometric image registration algorithm and digital focusing Open

Jingjing Zhao, Yonatan Winetraub, Edwin Yuan, Warren Chan, Sumaira Z. Aasi , et al. · 2020

Nanotherapeutic Shots through the Heart of Plaque Open

Yogendra Kanthi, Adam de la Zerda, Bryan Ronain Smith · 2020

The past several decades have brought significant advances in the application of clinical and preclinical nanoparticulate drugs in the field of cancer, but nanodrug development in cardiovascular disease has lagged in comparison. Improved u…

Difference-Frequency Ultrasound Imaging With Non-Linear Contrast Open

Yilei Li, Dina Polyak, Eli Johnson, Derek Yecies, Saba Shevidi , et al. · 2019

Conventional ultrasound imaging is based on the scattering of sound from inhomogeneities in the density and the speed of sound and is often used in medicine to resolve pathologic compared to normal tissue. Here we demonstrate a difference-…

A Spectral De-mixing Model for Triplex In Vivo Imaging of Optical Coherence Tomography Contrast Agents Open

Edwin Yuan, Peng Si, Saba Shevidi, Adam de la Zerda · 2019

The ability to detect multiple contrast agents simultaneously would greatly enhance Optical Coherence Tomography (OCT) images, providing nuanced biological context to physiological structures. However, previous OCT contrast agent work has …

Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging Open

Derek Yecies, Orly Liba, Elliott D. SoRelle, Rebecca Dutta, Edwin Yuan , et al. · 2019

Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells <i>in Vivo</i> through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation Open

Elliott D. SoRelle, Derek Yecies, Orly Liba, F. Chris Bennett, Claus Moritz Graef , et al. · 2019

By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages…

Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed <i>In Vivo</i> Lymphangiography Open

Peng Si, Saba Shevidi, Edwin Yuan, Ke Yuan, Ziv Lautman , et al. · 2019

Developing contrast-enhanced optical coherence tomography (OCT) techniques is important for specific imaging of tissue lesions, molecular imaging, cell-tracking, and highly sensitive microangiography and lymphangiography. Multiplexed OCT i…

Upper limit for angular compounding speckle reduction Open

Yonatan Winetraub, Chris Y. Wu, Graham P. Collins, Steven Chu, Adam de la Zerda · 2019

Angular compounding is a technique for reducing speckle noise in optical coherence tomography that is claimed to significantly improve the signal-to-noise ratio (SNR) of images without impairing their spatial resolution. Here, we examine h…

Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods Open

Rebecca Dutta, Orly Liba, Elliott D. SoRelle, Yonatan Winetraub, Vishnu C. Ramani , et al. · 2018

Optical coherence tomography (OCT) with significant speckle reduction can be used with highly-scattering contrast agents for noninvasive, contrast-enhanced imaging of living tissue at the cellular scale. The advantages of reduced speckle n…

Optimization of the Trade-Off Between Speckle Reduction and Axial Resolution in Frequency Compounding Open

Yilei Li, Yonatan Winetraub, Orly Liba, Adam de la Zerda, Steven Chu · 2018

We measured the reduction of speckle by frequency compounding using Gaussian pulses, which have the least time-bandwidth product. The experimental results obtained from a tissue mimicking phantom agree quantitatively with numerical simulat…

Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near Infrared Window for Enhanced Angiography in Live Animals Open

Peng Si, Edwin Yuan, Orly Liba, Yonatan Winetraub, Siavash Yousefi , et al. · 2018

Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived fro…

High-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging Open

Derek Yecies, Orly Liba, Elliott D. SoRelle, Rebecca Dutta, Edwin Yuan , et al. · 2018

Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative t…

Molecular Imaging with Optical Coherence Tomography and its Biomedical Applications Open

Adam de la Zerda · 2018

We developed a way to turn OCT into a molecular imaging modality through the development of novel nanoparticles. We explored its application in neurosurgery and in visualizing the role of the immune system in tumors.

Wide-field dynamic monitoring of immune cell trafficking in murine models of glioblastoma Open

Elliott D. SoRelle, Derek Yecies, Orly Liba, F. Chris Bennett, Claus Moritz Graef , et al. · 2017

Leukocyte populations, especially tumor-associated macrophages (TAMs), are capable of mediating both anti- and pro-tumor processes and play significant roles in the tumor microenvironment. Moreover, TAMs have been shown to exert substantia…

Erratum: Speckle-modulating optical coherence tomography in living mice and humans Open

Orly Liba, Matthew D. Lew, Elliott D. SoRelle, Rebecca Dutta, Debasish Sen , et al. · 2017

Speckle-modulating optical coherence tomography in living mice and humans Open

Orly Liba, Matthew D. Lew, Elliott D. SoRelle, Rebecca Dutta, Debasish Sen , et al. · 2017

Multimodal assessment of SERS nanoparticle biodistribution post ingestion reveals new potential for clinical translation of Raman imaging Open

Jos L. Campbell, Elliott D. SoRelle, Ohad Ilovich, Orly Liba, Michelle L. James , et al. · 2017

In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors Open

Peng Si, Debasish Sen, Rebecca Dutta, Siavash Yousefi, Roopa Dalal , et al. · 2017

Adam de la Zerda YOU? Author Swipe