Adam Gamson
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View article: The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice
The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice Open
Clostridioides difficile is the leading cause of antibiotic-associated intestinal infections. The pathogenesis of C. difficile infection (CDI) is driven by two protein exotoxins, TcdA and TcdB. The TcdB-targeting monoclonal antibody (mAb) …
View article: Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary <i>Clostridioides difficile</i> Isolates
Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary <i>Clostridioides difficile</i> Isolates Open
Background Clostridioides difficile toxin B is a virulence factor for C. difficile infections and a clinically validated target for prevention of C. difficile infection recurrence. AZD5148 is a toxin B–neutralizing human monoclonal antibod…
View article: Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in <i>Staphylococcus aureus</i> Infection
Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in <i>Staphylococcus aureus</i> Infection Open
Background Complications due to Staphylococcus aureus infections are a major health concern as current therapies lack broad coverage; therefore, development of a broad neutralizing therapy is critical. We previously showed that a monoclona…
View article: P-1055. Anti-Toxin B Neutralizing Monoclonal Antibody AZD5148 Provides Protection in a <i>Clostridioides difficile</i> Gnotobiotic Piglet Model
P-1055. Anti-Toxin B Neutralizing Monoclonal Antibody AZD5148 Provides Protection in a <i>Clostridioides difficile</i> Gnotobiotic Piglet Model Open
Background Clostridioides difficile infection (CDI) cause mild to severe diarrhea and can be life threatening. Because toxin B is a clinically validated target for CDI, we have generated an anti-toxin B neutralizing monoclonal antibody (mA…