Adam Hruby
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View article: Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons
Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons Open
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPRER) is one such conse…
View article: Beyond genes and environment: mapping biological stochasticity in aging
Beyond genes and environment: mapping biological stochasticity in aging Open
Aging is characterized by extensive variability in the onset of morbidity and mortality, even in genetically identical populations with carefully controlled environments. This points to the important role stochasticity plays in shaping the…
View article: Growth on stiffer substrates impacts animal health and longevity in C. elegans
Growth on stiffer substrates impacts animal health and longevity in C. elegans Open
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress on health and aging is a continuously growi…
View article: Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons
Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons Open
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR ER ) is one such conserved mech…
View article: Mechanical stress through growth on stiffer substrates impacts animal health and longevity in<i>C. elegans</i>
Mechanical stress through growth on stiffer substrates impacts animal health and longevity in<i>C. elegans</i> Open
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress on health and aging is a continuously growi…
View article: Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging Open
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: myc…
View article: Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging
Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging Open
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: myc…
View article: Glial-derived mitochondrial signals affect neuronal proteostasis and aging
Glial-derived mitochondrial signals affect neuronal proteostasis and aging Open
The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response…
View article: Glial-derived mitochondrial signals impact neuronal proteostasis and aging
Glial-derived mitochondrial signals impact neuronal proteostasis and aging Open
The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response…
View article: Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study
Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study Open
View article: Characterization of cellular senescence in aging skeletal muscle
Characterization of cellular senescence in aging skeletal muscle Open
View article: Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner Open