Adam J. Amorese
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View article: Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis
Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis Open
View article: (008) Chronic High Fat Diet Decreases Vaginal Smooth Muscle Tone but does not Affect Pelvic Floor Skeletal Muscle in Mice
(008) Chronic High Fat Diet Decreases Vaginal Smooth Muscle Tone but does not Affect Pelvic Floor Skeletal Muscle in Mice Open
Introduction Pelvic organ prolapse (POP) is a disease that affects the physical and mental health of women, as well as their quality of life. POP, regardless of severity, can be a direct cause of female sexual dysfunction (FSD) by producin…
View article: Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle Open
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in m…
View article: Home-Based Tele-Exercise in Musculoskeletal Conditions and Chronic Disease: A Literature Review
Home-Based Tele-Exercise in Musculoskeletal Conditions and Chronic Disease: A Literature Review Open
Exercise training is an essential component in the treatment or rehabilitation of various diseases and conditions. However, barriers to exercise such as the burdens of travel or time may hinder individuals' ability to participate in such t…
View article: Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo Open
Extracellular vesicles (EVs) are biomarkers and modifiers of human disease. EVs secreted by insulin-responsive tissues like skeletal muscle (SkM) and white adipose tissue (WAT) contribute to metabolic health and disease but the relative ab…
View article: Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability
Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability Open
Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nu…
View article: AJP-Cell Estrada et al. Supplemental Data
AJP-Cell Estrada et al. Supplemental Data Open
Supplemental data demonstrating that electrical stimulation of skeletal muscle does not increase EV secretion ex vivo.
View article: PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb
PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb Open
Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation - critical limb ischemia (CLI). We asked whether inflexibility in metabolism is cr…
View article: Effects of fasting on isolated murine skeletal muscle contractile function during acute hypoxia
Effects of fasting on isolated murine skeletal muscle contractile function during acute hypoxia Open
Stored muscle carbohydrate supply and energetic efficiency constrain muscle functional capacity during exercise and are influenced by common physiological variables (e.g. age, diet, and physical activity level). Whether these constraints a…
View article: PD36-03 CHRONIC HIGH FAT DIET INCREASES VAGINAL SPHINCTER LAXITY BUT NOT PELVIC FLOOR MUSCLE FUNCTION IN MICE
PD36-03 CHRONIC HIGH FAT DIET INCREASES VAGINAL SPHINCTER LAXITY BUT NOT PELVIC FLOOR MUSCLE FUNCTION IN MICE Open
You have accessJournal of UrologySexual Function/Dysfunction: Female (PD36)1 Apr 2020PD36-03 CHRONIC HIGH FAT DIET INCREASES VAGINAL SPHINCTER LAXITY BUT NOT PELVIC FLOOR MUSCLE FUNCTION IN MICE Lindsey Burleson*, Adam Amorese, Michelle Oy…
View article: Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation Open
Collectively, these results suggest that ERα function is superfluous in protecting against HFD-induced skeletal muscle metabolic derangements after postnatal development is complete.
View article: Effects of fasting induced carbohydrate depletion on murine ischemic skeletal muscle function
Effects of fasting induced carbohydrate depletion on murine ischemic skeletal muscle function Open
Stored muscle carbohydrate supply and energetic efficiency constrain muscle functional capacity during exercise and are influenced by common physiological variables (e.g. age, diet, and physical activity level). Whether these constraints a…
View article: Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function
Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function Open
Doxorubicin is an anthracycline-based chemotherapeutic that causes myotoxicity with symptoms persisting beyond treatment. Patients experience muscle pain, weakness, fatigue, and atrophy, but the underlying mechanisms are poorly understood.…
View article: Induced <i>in vivo</i> knockdown of the <i>Brca1</i> gene in skeletal muscle results in skeletal muscle weakness
Induced <i>in vivo</i> knockdown of the <i>Brca1</i> gene in skeletal muscle results in skeletal muscle weakness Open
Key points Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to …
View article: Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function
Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function Open
View article: Strain-Dependent Variation in Acute Ischemic Muscle Injury
Strain-Dependent Variation in Acute Ischemic Muscle Injury Open
View article: <i>Defining the STATus quo in muscle hypertrophy</i>. Focus on “Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3”
<i>Defining the STATus quo in muscle hypertrophy</i>. Focus on “Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3” Open
View article: The Effect of Metabolic Substrate on ROS Production During Muscle Contraction
The Effect of Metabolic Substrate on ROS Production During Muscle Contraction Open
Many different disease states are characterized by mitochondrial dysfunction, which results in excessive reactive oxygen species (ROS) production. In contrast muscle contraction induces ROS generation suggesting there is an optimal range o…