Adam J. Engler
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View article: Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer Open
Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despite solid in vitro evidence, its role in vivo remains largely speculative. Here we demonstrate that durotaxis actively …
View article: Applying physical principles to cancer research
Applying physical principles to cancer research Open
View article: Trionic all-optical biological voltage sensing via quantum statistics
Trionic all-optical biological voltage sensing via quantum statistics Open
View article: Adhesion strength of tumor cells predicts metastatic disease in vivo
Adhesion strength of tumor cells predicts metastatic disease in vivo Open
Although only a fraction of tumor cells contribute to metastatic disease, no prognostic biomarkers currently exist to identify these cells. We show that a physical marker-adhesion strength-predicts metastatic potential in a mouse breast ca…
View article: Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development
Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development Open
Illuminating the precise stepwise genetic programs directing cardiac development provides insights into the mechanisms of congenital heart disease and strategies for cardiac regenerative therapies. Here, we integrate in vitro and in vivo h…
View article: Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues
Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues Open
Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been u…
View article: Mechanobiological Modulation of <i>In Vitro</i> Astrocyte Reactivity Using Variable Gel Stiffness
Mechanobiological Modulation of <i>In Vitro</i> Astrocyte Reactivity Using Variable Gel Stiffness Open
After traumatic brain injury, the brain extracellular matrix undergoes structural rearrangement due to changes in matrix composition, activation of proteases, and deposition of chondroitin sulfate proteoglycans by reactive astrocytes to pr…
View article: Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments
Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments Open
View article: AP-1 signaling modulates cardiac fibroblast stress responses
AP-1 signaling modulates cardiac fibroblast stress responses Open
Matrix remodeling outcomes largely dictate patient survival post myocardial infarction. Moreover, human-restricted noncoding regulatory elements have been shown to worsen fibrosis, but their mechanism of action remains elusive. Here, we de…
View article: Conductive electrospun polymer improves stem cell-derived cardiomyocyte function and maturation
Conductive electrospun polymer improves stem cell-derived cardiomyocyte function and maturation Open
View article: YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis
YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis Open
Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1 . We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high …
View article: Using biophysical cues and biomaterials to improve genetic models
Using biophysical cues and biomaterials to improve genetic models Open
View article: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We performed whole…
View article: Author response: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Author response: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Hypopla…
View article: Cell contractility drives mechanical memory of oral squamous cell carcinoma
Cell contractility drives mechanical memory of oral squamous cell carcinoma Open
Oral cancer cells sense and respond to matrix stiffness via myosin contractility. As part of their response, they use AKT and FAK signaling to retain and recall the ‘memory’ developed within the tumor core to remain highly migratory and me…
View article: Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity
Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity Open
9p21.3 locus polymorphisms have the strongest correlation with coronary artery disease, but as a noncoding locus, disease connection is enigmatic. The lncRNA ANRIL found in 9p21.3 may regulate vascular smooth muscle cell (VSMC) phenotype t…
View article: Getting physical: Material mechanics is an intrinsic cell cue
Getting physical: Material mechanics is an intrinsic cell cue Open
View article: Data from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Data from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential Open
Tumors are heterogeneous and composed of cells with different dissemination abilities. Despite significant effort, there is no universal biological marker that serves as a metric for metastatic potential of solid tumors. Common to dissemin…
View article: Supplementary Data and Tables from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Supplementary Data and Tables from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential Open
Complete Supplemental Figures 1-8 and Supplemental Tables 1-2 are embedded in this file. Each item contains its respective legend.
View article: Supplementary Data and Tables from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Supplementary Data and Tables from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential Open
Complete Supplemental Figures 1-8 and Supplemental Tables 1-2 are embedded in this file. Each item contains its respective legend.
View article: Data from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Data from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential Open
Tumors are heterogeneous and composed of cells with different dissemination abilities. Despite significant effort, there is no universal biological marker that serves as a metric for metastatic potential of solid tumors. Common to dissemin…
View article: Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation Open
Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
View article: Data from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
Data from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation Open
The mammary gland consists of a polarized epithelium surrounded by a basement membrane matrix that forms a series of branching ducts ending in hollow, sphere-like acini. Essential roles for the epithelial basement membrane during acinar di…
View article: Data from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
Data from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation Open
The mammary gland consists of a polarized epithelium surrounded by a basement membrane matrix that forms a series of branching ducts ending in hollow, sphere-like acini. Essential roles for the epithelial basement membrane during acinar di…
View article: Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation Open
Supplementary Figures 1-4 from Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation
View article: Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs Open
View article: Mechanobiology of the cell nucleus
Mechanobiology of the cell nucleus Open
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View article: Recent advancements and future requirements in vascularization of cortical organoids
Recent advancements and future requirements in vascularization of cortical organoids Open
The fields of tissue engineering and disease modeling have become increasingly cognizant of the need to create complex and mature structures in vitro to adequately mimic the in vivo niche. Specifically for neural applications, human brain …
View article: Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear
Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear Open
View article: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore perfo…