Adam J. Ronk
YOU?
Author Swipe
View article: Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin
Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin Open
Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV o…
View article: A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection
A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection Open
View article: Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats
Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats Open
The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental q…
View article: Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection Open
View article: IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern Open
Monoclonal antibodies are a promising approach to treat COVID-19, however the emergence of SARS-CoV-2 variants has challenged the efficacy and future of these therapies. Antibody cocktails are being employed to mitigate these challenges, b…
View article: IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern Open
Monoclonal antibodies are a promising approach to treat COVID-19, however the emergence of SARS-CoV-2 variants has challenged the efficacy and future of these therapies. Antibody cocktails are being employed to mitigate these challenges, b…
View article: Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly Open
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35’s engagement in different functions are not well-understood. We p…
View article: Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability
Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability Open
Lassa virus is endemic in large parts of West Africa and causes a hemorrhagic fever. Recent years have seen several serious outbreaks of Lassa fever with high mortality rates. A vaccine to curtail infection is urgently needed. The developm…
View article: COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models Open
Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic effec…
View article: A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19 Open
View article: Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection
Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection Open
(Cell Reports 35, 109086-1–13.e1–e9; May 4, 2021) In the originally published version of this article, the incorrect DOI was listed. The original/source data for all figures can be found at https://doi.org/10.17632/36yhsg4b36.1. The paper …
View article: Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection
Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection Open
View article: Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failur…
View article: COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models Open
One year into the Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), effective treatments are still needed1–3. Monoclonal antibodies, given alone or as part of a …
View article: A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19 Open
SUMMARY The development of effective countermeasures against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-compe…
View article: Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model Open
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respirator…
View article: Species-Specific Evolution of Ebola Virus during Replication in Human and Bat Cells
Species-Specific Evolution of Ebola Virus during Replication in Human and Bat Cells Open
Ebola virus (EBOV) causes a severe, often fatal disease in humans and nonhuman primates. Within the past decade, EBOV has caused two large and difficult-to-control outbreaks, one of which recently ended in the Democratic Republic of the Co…
View article: Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats
Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats Open
The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental q…
View article: Ebola and Marburg Virus Infection in Bats Induces a Systemic Response
Ebola and Marburg Virus Infection in Bats Induces a Systemic Response Open
View article: Ebola Virus Produces Discrete Small Noncoding RNAs Independently of the Host MicroRNA Pathway Which Lack RNA Interference Activity in Bat and Human Cells
Ebola Virus Produces Discrete Small Noncoding RNAs Independently of the Host MicroRNA Pathway Which Lack RNA Interference Activity in Bat and Human Cells Open
Here, we report the discovery, via deep sequencing, of numerous noncoding RNAs (ncRNAs) derived from both EBOV and MARV during infection of both bat and human cell lines. In addition to identifying several novel ncRNAs from both viruses, w…
View article: <i>Drosophila</i>Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
<i>Drosophila</i>Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution Open
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and …