Adam J. Woods
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View article: The Importance of Tissue Identity in Modeling Transcranial Direct Current Stimulation
The Importance of Tissue Identity in Modeling Transcranial Direct Current Stimulation Open
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique where electrodes applied to the scalp deliver electrical currents and modify the neuronal cell environment. Research shows that tDCS can improve c…
View article: Functional connectivity in distributed cortical networks associated with semantic processing in healthy older adults
Functional connectivity in distributed cortical networks associated with semantic processing in healthy older adults Open
Objective While word knowledge is typically well-preserved in aging, declines in executive control often observed in older adults may impact access and application of this knowledge. Evidence suggests aging is associated with declines in s…
View article: Network segregation is associated with processing speed in the cognitively healthy oldest-old
Network segregation is associated with processing speed in the cognitively healthy oldest-old Open
The brain is organized into systems and networks of interacting components. The functional connections among these components give insight into the brain’s organization and may underlie some cognitive effects of aging. Examining the relati…
View article: Building tDCS Digital Twins: AI-Powered Prediction of Personalized Electrical Field Maps from MRI
Building tDCS Digital Twins: AI-Powered Prediction of Personalized Electrical Field Maps from MRI Open
View article: TDCS Reverses Learning Deficits in Mild Cognitive Impairment: Results of the MEMORI Study, a Randomized Double Blind Clinical Trial
TDCS Reverses Learning Deficits in Mild Cognitive Impairment: Results of the MEMORI Study, a Randomized Double Blind Clinical Trial Open
View article: Baseline Clinical Markers and Machine Learning-Based Prediction of tDCS Treatment Outcomes in Anxiety Disorders
Baseline Clinical Markers and Machine Learning-Based Prediction of tDCS Treatment Outcomes in Anxiety Disorders Open
View article: Practical considerations in modeling tDCS in older adults
Practical considerations in modeling tDCS in older adults Open
View article: Effect of transcranial direct current stimulation with cognitive training on executive functions in healthy older adults: a secondary analysis from the ACT trial
Effect of transcranial direct current stimulation with cognitive training on executive functions in healthy older adults: a secondary analysis from the ACT trial Open
View article: Deep Learning with Imbalanced Data Identifies Early Mild Cognitive Impairment Amongst Typical Older Adults (Preprint)
Deep Learning with Imbalanced Data Identifies Early Mild Cognitive Impairment Amongst Typical Older Adults (Preprint) Open
BACKGROUND Mild cognitive impairment is a transitional stage between normal cognitive aging and dementia. Identifying individuals at the preMCI stage, prior to the onset of mild cognitive decline, can be pivotal for early interventions ai…
View article: Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words Open
View article: Facilitation of working memory capacity by transcranial direct current stimulation: a secondary analysis from the augmenting cognitive training in older adults (ACT) study
Facilitation of working memory capacity by transcranial direct current stimulation: a secondary analysis from the augmenting cognitive training in older adults (ACT) study Open
View article: The ENIGMA Neuromodulation Working Group: Goals, Challenges, and Opportunities for the Field
The ENIGMA Neuromodulation Working Group: Goals, Challenges, and Opportunities for the Field Open
Since 2009, the ENIGMA Consortium has brought together neuroimaging researchers from over 45 countries to perform some of the largest international studies of over 30 major brain disorders. The ENIGMA working groups tackle the growing chal…
View article: Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults
Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults Open
View article: tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT)
tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT) Open
View article: Precise and rapid whole-head segmentation from magnetic resonance images of older adults using deep learning
Precise and rapid whole-head segmentation from magnetic resonance images of older adults using deep learning Open
Whole-head segmentation from Magnetic Resonance Images (MRI) establishes the foundation for individualized computational models using finite element method (FEM). This foundation paves the path for computer-aided solutions in fields such a…
View article: 53 Change in Cerebral Metabolite Concentrations Following Bariatric Surgery
53 Change in Cerebral Metabolite Concentrations Following Bariatric Surgery Open
Objective: Obesity is associated with adverse effects on brain health, including increased risk for neurodegenerative diseases. Changes in cerebral metabolism may underlie or precede structural and functional brain changes. While bariatric…
View article: 1 Task-Based Functional Connectivity and Network Segregation of the Useful Field of View (UFOV) fMRI task
1 Task-Based Functional Connectivity and Network Segregation of the Useful Field of View (UFOV) fMRI task Open
Objective: Interventions using a cognitive training paradigm called the Useful Field of View (UFOV) task have shown to be efficacious in slowing cognitive decline. However, no studies have looked at the engagement of functional networks du…
View article: 9 Connecting memory and functional brain networks in older adults: a resting state fMRI study
9 Connecting memory and functional brain networks in older adults: a resting state fMRI study Open
Objective: Nonpathological aging has been linked to decline in both verbal and visuospatial memory abilities in older adults. Disruptions in resting-state functional connectivity within well-characterized, higherorder cognitive brain netwo…
View article: 78 BVMT-R Learning Ratio Moderates Cognitive Training Gains in Useful Field of View Task in Healthy Older Adults
78 BVMT-R Learning Ratio Moderates Cognitive Training Gains in Useful Field of View Task in Healthy Older Adults Open
Objective: Cognitive training using a visual speed-of-processing task, called the Useful Field of View (UFOV) task, reduced dementia risk and reduced decline in activities of daily living at a 10-year follow-up in older adults. However, th…
View article: 72 Cognitive Training Paired with Bifrontal tDCS Decreases Depressive Symptoms in a Non-Clinical Sample of Older Adults: Preliminary Evidence
72 Cognitive Training Paired with Bifrontal tDCS Decreases Depressive Symptoms in a Non-Clinical Sample of Older Adults: Preliminary Evidence Open
Objective: Subthreshold depressive symptoms are both prevalent and associated with negative outcomes in older adults, including conversion to major depressive disorder and other medical conditions. Antidepressants are not recommended as fi…
View article: 53 2-Back Performance Does Not Differ Between Cognitive Training Groups in Older Adults Without Dementia
53 2-Back Performance Does Not Differ Between Cognitive Training Groups in Older Adults Without Dementia Open
Objective: Cognitive training is a non-pharmacological intervention aimed at improving cognitive function across a single or multiple domains. Although the underlying mechanisms of cognitive training and transfer effects are not well-chara…
View article: 3 Associations Between Exercise Type, Fluid Intelligence, and Processing Speed in the Oldest-Old
3 Associations Between Exercise Type, Fluid Intelligence, and Processing Speed in the Oldest-Old Open
Objective: Exercise elicits a variety of physiological responses in the body. In the brain, exercise can modulate levels of neurotransmitters and other neurochemicals as well as sparking neurogenesis and structural changes. Downstream psyc…
View article: 28 Factor Structure of Conventional Neuropsychological Tests and NIH-Toolbox in Healthy Older Adults
28 Factor Structure of Conventional Neuropsychological Tests and NIH-Toolbox in Healthy Older Adults Open
Objective: The National Institutes of Health-Toolbox cognition battery (NIH-TCB) is widely used in cognitive aging studies and includes measures in cognitive domains evaluated for dimensional structure and psychometric properties in prior …
View article: 2 Higher White Matter Hyperintensity Load Adversely Affects Pre-Post Proximal Cognitive Training Performance in Healthy Older Adults
2 Higher White Matter Hyperintensity Load Adversely Affects Pre-Post Proximal Cognitive Training Performance in Healthy Older Adults Open
Objective: Cognitive training has shown promise for improving cognition in older adults. Aging involves a variety of neuroanatomical changes that may affect response to cognitive training. White matter hyperintensities (WMH) are one common…
View article: 6 Adjunctive Transcranial Direct Current Stimulation and Cognitive Training Alters Default Mode and Frontoparietal Control Network Connectivity in Older Adults
6 Adjunctive Transcranial Direct Current Stimulation and Cognitive Training Alters Default Mode and Frontoparietal Control Network Connectivity in Older Adults Open
Objective: Aging is associated with disruptions in functional connectivity within the default mode (DMN), frontoparietal control (FPCN), and cingulo-opercular (CON) resting-state networks. Greater within-network connectivity predicts bette…
View article: 18 Regional patterns of mitochondrial function using phosphorus magnetic resonance spectroscopy in older adults at-risk for Alzheimer’s disease.
18 Regional patterns of mitochondrial function using phosphorus magnetic resonance spectroscopy in older adults at-risk for Alzheimer’s disease. Open
Objective: The brain is reliant on mitochondria to carry out a host of vital cellular functions (e.g., energy metabolism, respiration, apoptosis) to maintain neuronal integrity. Clinically relevant, dysfunctional mitochondria have been imp…
View article: 61 Network Segregation Predicts Processing Speed in the Cognitively Healthy Oldest-old
61 Network Segregation Predicts Processing Speed in the Cognitively Healthy Oldest-old Open
Objective: Understanding the factors contributing to optimal cognitive function throughout the aging process is essential to better understand successful cognitive aging. Processing speed is an age sensitive cognitive domain that usually d…
View article: DOMINO++: Domain-aware Loss Regularization for Deep Learning Generalizability
DOMINO++: Domain-aware Loss Regularization for Deep Learning Generalizability Open
Out-of-distribution (OOD) generalization poses a serious challenge for modern deep learning (DL). OOD data consists of test data that is significantly different from the model's training data. DL models that perform well on in-domain test …
View article: Frontal adenosine triphosphate markers from 31P MRS are associated with cognitive performance in healthy older adults: preliminary findings
Frontal adenosine triphosphate markers from 31P MRS are associated with cognitive performance in healthy older adults: preliminary findings Open
Aging is associated with declines in mitochondrial efficiency and energy production which directly impacts the availability of adenosine triphosphate (ATP), which contains high energy phosphates critical for a variety of cellular functions…
View article: Machine-learning defined precision tDCS for improving cognitive function
Machine-learning defined precision tDCS for improving cognitive function Open
The results of this study serve as a foundation for a custom dose optimization strategy towards precision medicine in tDCS to improve outcomes in cognitive decline remediation for older adults.