Adam Junka
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View article: Evaluation of 2,7-Naphthyridines as Targeted Anti-Staphylococcal Candidates with Microbiota-Sparing Properties
Evaluation of 2,7-Naphthyridines as Targeted Anti-Staphylococcal Candidates with Microbiota-Sparing Properties Open
The rising resistance of bacterial and fungal strains, particularly in biofilm form, is diminishing the efficacy of available therapies and poses a major threat to human health. This highlights the need for new antimicrobial agents. A revi…
View article: Octenidine Lozenges Intended for Oral Administration Display In Vitro Activity Against Oropharyngeal Pathogens and Safety Toward Intestinal Microbiota
Octenidine Lozenges Intended for Oral Administration Display In Vitro Activity Against Oropharyngeal Pathogens and Safety Toward Intestinal Microbiota Open
Pharyngitis is a leading cause of outpatient antibiotic use, despite its typically viral or self-limiting nature. Such unnecessary antibiotic therapies are not only the cause of increasing antibiotic resistance, but also significant change…
View article: Toward essential oil stewardship: strain-resolved evaluation of thyme oil activity against Pseudomonas aeruginosa
Toward essential oil stewardship: strain-resolved evaluation of thyme oil activity against Pseudomonas aeruginosa Open
The rising interest in essential oils (EOs) as antimicrobial agents demands evaluation frameworks that provide structured, reproducible assessments. In this study, we examined the strain-dependent response of Pseudomonas aeruginosa to phar…
View article: Synthesis and Characterization of Curcumin-Polycaprolactone Block Copolymers for Biomedical Applications
Synthesis and Characterization of Curcumin-Polycaprolactone Block Copolymers for Biomedical Applications Open
Polycaprolactone (PCL) is widely utilized in biomedical applications such as tissue engineering and drug delivery; however, its limited bioactivity remains a key challenge. In this study, bioactive curcumin–polycaprolactone block copolymer…
View article: Establishing essential oil stewardship through the case of rosemary and thyme oils against Staphylococcus aureus
Establishing essential oil stewardship through the case of rosemary and thyme oils against Staphylococcus aureus Open
Essential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations—failing to meet the standards expected of modern anti-i…
View article: Controlling Flow Dynamics and Permeability in Perfusable Vascular Constructs Using Volumetric 3D Printing
Controlling Flow Dynamics and Permeability in Perfusable Vascular Constructs Using Volumetric 3D Printing Open
Creating perfusable vascular networks that replicate physiological flow remains a key challenge in tissue engineering. Here, we present a volumetric 3D printing (Vol3DP) method for fabricating tunable, biologically relevant vascular struct…
View article: Establishing Essential Oil Stewardship Through the Case of Rosemary and Thyme Oils Against <i>Staphylococcus aureus</i>
Establishing Essential Oil Stewardship Through the Case of Rosemary and Thyme Oils Against <i>Staphylococcus aureus</i> Open
Essential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations - failing to meet the standards expected of modern anti…
View article: Targeting Ocular Biofilms with Plant-Derived Antimicrobials in the Era of Antibiotic Resistance
Targeting Ocular Biofilms with Plant-Derived Antimicrobials in the Era of Antibiotic Resistance Open
Microbial biofilms present a formidable challenge in ophthalmology. Their intrinsic resistance to antibiotics and evasion of host immune defenses significantly complicate treatments for ocular infections such as conjunctivitis, keratitis, …
View article: Orally Administered Octenidine Is Effective Against Oral/Throat Pathogens and Safe for the Normal Microbiota of the Oral Cavity, Throat and Large Intestine
Orally Administered Octenidine Is Effective Against Oral/Throat Pathogens and Safe for the Normal Microbiota of the Oral Cavity, Throat and Large Intestine Open
Pharyngitis is a leading cause of outpatient antibiotic use, despite its typically viral or self-limiting nature. Such unnecessary antibiotic therapies are not only the cause of increasing antibiotic resistance, but also significant change…
View article: Toward Essential Oil Stewardship: Strain-Resolved Evaluation of Thyme Oil Activity Against <i>Pseudomonas aeruginosa</i>
Toward Essential Oil Stewardship: Strain-Resolved Evaluation of Thyme Oil Activity Against <i>Pseudomonas aeruginosa</i> Open
The rising interest in essential oils (EOs) as antimicrobial agents demands evaluation frameworks that move beyond anecdotal efficacy and toward structured, reproducible assessment. In this study, we examined the strain-dependent response …
View article: Synergy of Tetracyclines and Potassium Azeloyl Diglycinate (Azeloglycine) in Hydrogels: Evaluation of Stability, Antimicrobial Activity, and Physicochemical Properties
Synergy of Tetracyclines and Potassium Azeloyl Diglycinate (Azeloglycine) in Hydrogels: Evaluation of Stability, Antimicrobial Activity, and Physicochemical Properties Open
Acne vulgaris is one of the most common dermatological diseases and has a complex etiology. Despite the wide range of available therapeutic options, modern and effective solutions are still being sought, particularly in the area of topical…
View article: Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine
Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine Open
View article: (1→3)-α-d-Glucan from the Pink Oyster Mushroom (Pleurotus djamor): Structural Features
(1→3)-α-d-Glucan from the Pink Oyster Mushroom (Pleurotus djamor): Structural Features Open
(1→3)-α-d-Glucan is an important component of the cell wall of most fungi. The polymer has many applications, including as a therapeutic agent in the prevention or treatment of various diseases, as well as a heavy metal sorbent and a compo…
View article: Impact of amber powdered waste on the processability and properties of PCL-based materials
Impact of amber powdered waste on the processability and properties of PCL-based materials Open
It is the first comprehensive study showing the effect of amber particles in a biodegradable polymer matrix. The effect of amber powdered waste (AbW) on poly(ε-caprolactone) (PCL) processing was evaluated, along with the influence of diffe…
View article: The Potential Impact of Edible Fruit Extracts on Bacterial Nucleases in Preliminary Research—In Silico and In Vitro Insight
The Potential Impact of Edible Fruit Extracts on Bacterial Nucleases in Preliminary Research—In Silico and In Vitro Insight Open
The extracts from fruits of Chaenomeles japonica (Thunb.) Lindl. ex Spach (CJE), Cornus mas L. (CME), and Hippophaё rhamnoides L. (HRE) are known inhibitors of a variety of eukaryotic hydrolases, engaged in the digestion of fats and polysa…
View article: Borax - and tannic acid-based post-3D-printing treatment to tune the mechanical properties of scaffolds
Borax - and tannic acid-based post-3D-printing treatment to tune the mechanical properties of scaffolds Open
Post-processing of DLP-printed polyethylene glycol diacrylate (PEGDA)/polyvinyl alcohol (PVA) resins with tannic acid (TA) enhanced their mechanical properties and introduced bioactive functionalities.
View article: Novel Isoxazole-Based Antifungal Drug Candidates
Novel Isoxazole-Based Antifungal Drug Candidates Open
Microbiological communities have a significant impact on health and disease. Candida are ubiquitous fungal pathogens that colonize the mucosal surfaces of the genital, urinary, respiratory, and gastrointestinal tracts, as well as the oral …
View article: In Vitro and In Vivo Translational Insights into the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections
In Vitro and In Vivo Translational Insights into the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections Open
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study e…
View article: In Vitro and In Vivo Translational Insights on the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections
In Vitro and In Vivo Translational Insights on the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections Open
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study e…
View article: Assessment of Biological Activity of Water-Soluble Polysaccharides Isolated From Cultivated Pleurotus pulmonarius and Pleurotus citrinopileatus
Assessment of Biological Activity of Water-Soluble Polysaccharides Isolated From Cultivated Pleurotus pulmonarius and Pleurotus citrinopileatus Open
Anti-proliferative and antioxidant activities of Pleurotus pulmonarius and P. citrinopileatus water-soluble polysaccharides were examined using human colon adenocarcinoma (HT-29) and human normal colonic epithelial (CCD841 CoTr) cell lines…
View article: Mechanical and Antimicrobial Properties of the Graphene-Polyamide 6 Composite
Mechanical and Antimicrobial Properties of the Graphene-Polyamide 6 Composite Open
This paper presents the synthesis and characterization of graphene–polymer composites, focusing on their mechanical and antibacterial properties. Graphene flakes were obtained via an electrochemical method and integrated into polyamide 6 (…
View article: The Assessment of Physicochemical and Antimicrobial Properties of Hydrophilic Gels Containing Tetracycline Hydrochloride and Various Concentrations of Ethanol
The Assessment of Physicochemical and Antimicrobial Properties of Hydrophilic Gels Containing Tetracycline Hydrochloride and Various Concentrations of Ethanol Open
The high prevalence of acne, which affects nearly 85% of adolescents and young adults, underscores the importance of exploring new therapeutic solutions. The aim of the present study was to design a stable hydrogel formulation containing t…
View article: No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide
No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide Open
This study evaluates the in vitro antimicrobial efficacy and cytotoxicity of acidified sodium chlorite (ASC), a source of chlorine dioxide. Despite its controversial promotion in alternative medicine as a cure-all solution, known as “Mirac…
View article: Abietic Acid as a Novel Agent against Ocular Biofilms: An In Vitro and Preliminary In Vivo Investigation
Abietic Acid as a Novel Agent against Ocular Biofilms: An In Vitro and Preliminary In Vivo Investigation Open
Biofilm-related ocular infections can lead to vision loss and are difficult to treat with antibiotics due to challenges with application and increasing microbial resistance. In turn, the design and testing of new synthetic drugs is a time-…
View article: The chronic wound milieu changes essential oils' antibiofilm activity—an in vitro and larval model study
The chronic wound milieu changes essential oils' antibiofilm activity—an in vitro and larval model study Open
View article: Oxidation of Myrtenol in Porphyrin-Based Photocatalytic System to Myrtenal Oxide - a Novel Terpene Alcohol Derivative with Anti-Microbial and Anti-Cancer Properties
Oxidation of Myrtenol in Porphyrin-Based Photocatalytic System to Myrtenal Oxide - a Novel Terpene Alcohol Derivative with Anti-Microbial and Anti-Cancer Properties Open
View article: Compounds of Edible Fruits vs. Bacterial Nucleases – in Silico Study and Preliminary in Vitro Research on Their Influence on Pathogenic and Probiotic Microbial Strains
Compounds of Edible Fruits vs. Bacterial Nucleases – in Silico Study and Preliminary in Vitro Research on Their Influence on Pathogenic and Probiotic Microbial Strains Open
View article: Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu
Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu Open
Credible assessment methods must be applied to evaluate antiseptics’ in vitro activity reliably. Studies indicate that the medium for biofilm culturing should resemble the conditions present at the site of infection. We cultured S. aureus,…
View article: An epidemic behind the bars: AIDS in American prisons
An epidemic behind the bars: AIDS in American prisons Open
Recommendation:By analyzing current research, the article provides useful strategies to prevent, detect, and treat HIV infection among the incarcerated population in the United States, emphasizing the critical need for interventions to mit…
View article: Antimicrobial and Cytotoxic Activities of Water-Soluble Isoxazole-Linked 1,3,4-Oxadiazole with Delocalized Charge: In Vitro and In Vivo Results
Antimicrobial and Cytotoxic Activities of Water-Soluble Isoxazole-Linked 1,3,4-Oxadiazole with Delocalized Charge: In Vitro and In Vivo Results Open
The distinct structure of cationic organic compounds plays a pivotal role in enhancing their water solubility, which in turn influences their bioavailability. A representative of these compounds, which contains a delocalized charge, is 5-a…