Kerry Dobbs
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View article: 293 Discovery and characterization of a first-in-class de novo AI-designed TCR-mimetic-CAR targeting HLA-A2:01+ PRAME+ cancers
293 Discovery and characterization of a first-in-class de novo AI-designed TCR-mimetic-CAR targeting HLA-A2:01+ PRAME+ cancers Open
View article: Joint neutrino oscillation analysis from the T2K and NOvA experiments
Joint neutrino oscillation analysis from the T2K and NOvA experiments Open
View article: Search for Accelerator-Produced Sub-GeV Dark Matter with the NOvA Near Detector
Search for Accelerator-Produced Sub-GeV Dark Matter with the NOvA Near Detector Open
The NuMI facility at Fermilab produces a high-intensity beam of muon neutrinos and antineutrinos, designed to study neutrino oscillations. This beam may also be a source of dark matter particles produced through a light mediator. We search…
Measurement of in charged current -nucleus interactions at using the NOvA Near Detector Open
View article: TGFβ links EBV to multisystem inflammatory syndrome in children
TGFβ links EBV to multisystem inflammatory syndrome in children Open
In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock 1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a…
View article: Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA
Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA Open
We report a search for neutrino oscillations to sterile neutrinos under a model with three active and one sterile neutrinos (3+1 model). This analysis uses the NOvA detectors exposed to the NuMI beam, running in neutrino mode. The data exp…
View article: A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2
A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2 Open
We describe the establishment and current content of the ImmuneCODE™ database, which includes hundreds of millions of T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with the SARS-CoV-2 virus, as well as ove…
View article: Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels
Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels Open
Introduction T cells are involved in the early identification and clearance of viral infections and also support the development of antibodies by B cells. This central role for T cells makes them a desirable target for assessing the immune…
View article: Measurement of the double-differential cross section of muon-neutrino charged-current interactions with low hadronic energy in the NOvA Near Detector
Measurement of the double-differential cross section of muon-neutrino charged-current interactions with low hadronic energy in the NOvA Near Detector Open
The NOvA collaboration reports cross-section measurements for $ν_μ$ charged-current interactions with low hadronic energy (maximum kinetic energy of 250 MeV for protons and 175 MeV for pions) in the NOvA Near Detector. The results are pres…
View article: Measurement of d2sigma/d|q|dEavail in charged current neutrino-nucleus interactions at <Ev> = 1.86 GeV using the NOvA Near Detector
Measurement of d2sigma/d|q|dEavail in charged current neutrino-nucleus interactions at <Ev> = 1.86 GeV using the NOvA Near Detector Open
Double- and single-differential cross sections for inclusive charged-current neutrino-nucleus scattering are reported for the kinematic domain 0 to 2 GeV/c in three-momentum transfer and 0 to 2 GeV in available energy, at a mean muon-neutr…
View article: Measurement of d2sigma/d|q|dEavail in charged current neutrino-nucleus interactions at = 1.86 GeV using the NOvA Near Detector
Measurement of d2sigma/d|q|dEavail in charged current neutrino-nucleus interactions at = 1.86 GeV using the NOvA Near Detector Open
Double- and single-differential cross sections for inclusive charged-current neutrino-nucleus scattering are reported for the kinematic domain 0 to 2 GeV/c in three-momentum transfer and 0 to 2 GeV in available energy, at a mean muon-neutr…
View article: Human TMEFF1 is a restriction factor for herpes simplex virus in the brain
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain Open
View article: SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency Open
Inherited deficiency of the RNA lariat–debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear. We report inherited DBR1 deficiency in …
View article: Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency Open
View article: Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals
Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals Open
View article: Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation
Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation Open
Omenn Syndrome (OS) is a rare hematological disorder, caused by hypomorphic mutations in genes involved in B-/T-cell receptor (BCR/TCR) rearrangement that result in impaired lymphocyte development and immunodeficiency. Notwithstanding, few…
View article: Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency
Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency Open
Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death. We report an otherwise healthy patient…
View article: Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation
Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation Open
Primary atopic disorders are a group of inborn errors of immunity that skew the immune system toward severe allergic disease. Defining the biology underlying these extreme monogenic phenotypes reveals shared mechanisms underlying common po…
View article: Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)
Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C) Open
View article: A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation
A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation Open
View article: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq Open
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poor…
View article: ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data
ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data Open
View article: Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq Open
Article Figures and data Abstract Editor's evaluation Introduction Results and discussion Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Phage i…
View article: Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)
Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C) Open
Multisystem Inflammatory Syndrome in Children (MIS-C) is a systemic inflammatory condition that follows SARS-CoV2 infection or exposure in children. Clinical presentations are highly variable and include fever, gastrointestinal (GI) diseas…
View article: Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19
Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19 Open
Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease, including multisystem inflammat…
View article: Clonal hematopoiesis is not significantly associated with COVID-19 disease severity
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity Open
View article: Abnormal antibodies to self-carbohydrates in SARS-CoV-2-infected patients
Abnormal antibodies to self-carbohydrates in SARS-CoV-2-infected patients Open
Our immune system is critical for preventing and treating SARS-CoV-2 infections, but aberrant immune responses can have deleterious effects. While antibodies to glycans could recognize the virus and influence the clinical outcome, little i…
View article: Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons
Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons Open
View article: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin Open
The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patien…
View article: Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference
Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference Open