Adam Krzystyniak
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View article: Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses
Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses Open
Stress resilience is the ability of neuronal networks to maintain their function despite the stress exposure. Using a mouse model we investigate stress resilience phenomenon. To assess the resilient and anhedonic behavioral phenotypes deve…
View article: 2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation
2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation Open
Cells may undergo senescence in response to DNA damage, which is associated with cell cycle arrest, altered gene expression and altered cell morphology. Protein palmitoylation is one of the mechanisms by which the DNA damage response is re…
View article: Jak odmłodzić mózg
Jak odmłodzić mózg Open
Aging is a process that leads to the development of age-related chronic diseases. The causes of aging, and consequently these diseases, are rooted in fundamental biological mechanisms. Cognitive impairments are one of the most prominent as…
View article: Stress Resilience is an Active and Multifactorial Process Manifested by Structural, Functional, and Molecular Changes in Synapses
Stress Resilience is an Active and Multifactorial Process Manifested by Structural, Functional, and Molecular Changes in Synapses Open
View article: Correction to “Glycogen phosphorylase inhibition improves cognitive function of aged mice”
Correction to “Glycogen phosphorylase inhibition improves cognitive function of aged mice” Open
View article: Glycogen phosphorylase inhibition improves cognitive function of aged mice
Glycogen phosphorylase inhibition improves cognitive function of aged mice Open
Inhibition of glycogen breakdown blocks memory formation in young animals, but it stimulates the maintenance of the long‐term potentiation, a cellular mechanism of memory formation, in hippocampal slices of old animals. Here, we report tha…
View article: Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells
Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells Open
Normal cells under stressful conditions such as DNA damage or excessive mitogenic signaling may undergo senescence, which is associated with cell cycle arrest and induction of a proinflammatory phenotype. Accumulation of senescent cells ma…
View article: The molecular fingerprint of stress resilience
The molecular fingerprint of stress resilience Open
Stress resilience is an ability of neuronal networks to maintain their function despite the stress exposure. In this study, we investigate whether stress resilience is an actively developed dynamic process in adult mice. In order to assess…
View article: Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior
Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior Open
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity that may be caused by abnormal serotonergic signaling. Using a combination of behavioral, biochemical, and imaging methods, we analyze 5-HT7R/MMP-9 …
View article: Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile
Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile Open
Aging is associated with cognitive decline and accumulation of senescent cells in various tissues and organs. Senolytic agents such as dasatinib and quercetin (D+Q) in combination have been shown to target senescent cells and ameliorate sy…
View article: Cellular Senescence in Brain Aging
Cellular Senescence in Brain Aging Open
Aging of the brain can manifest itself as a memory and cognitive decline, which has been shown to frequently coincide with changes in the structural plasticity of dendritic spines. Decreased number and maturity of spines in aged animals an…
View article: Nowoczesne techniki wykorzystywane do badań eksperymentalnych zaburzonej plastyczności neuronalnej w depresji
Nowoczesne techniki wykorzystywane do badań eksperymentalnych zaburzonej plastyczności neuronalnej w depresji Open
Depresja należy obecnie do najczęstszych chorób psychicznych na świecie, lecz dostępność jej skutecznych terapii jest ograniczona. Brak pełnego zrozumienia mechanizmów molekularnych i komórkowych leżących u podstaw tej choroby utrudnia opr…
View article: Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors Open
View article: Stress-induced Changes in the S-palmitoylation and S-nitrosylation of Synaptic Proteins*[S]
Stress-induced Changes in the S-palmitoylation and S-nitrosylation of Synaptic Proteins*[S] Open
The precise regulation of synaptic integrity is critical for neuronal network connectivity and proper brain function. Essential aspects of the activity and localization of synaptic proteins are regulated by posttranslational modifications.…
View article: Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus
Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus Open
Ketamine is an N-methyl-d-aspartate receptor antagonist that has gained wide attention as a potent antidepressant. It has also been recently reported to have prophylactic effects in animal models of depression and anxiety. Alterations of n…
View article: Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins
Stress-induced changes in the S-palmitoylation and S-nitrosylation of synaptic proteins Open
Summary The precise regulation of synaptic integrity is critical for neuronal network connectivity and proper brain function. Essential aspects of the activity and localization of synaptic proteins are regulated by posttranslational modifi…