Adam Leach
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View article: Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies
Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies Open
Selective targeting of myeloid cells (MCs) holds therapeutic potential as an immuno‐oncology approach. However, MC targeting using existing gene delivery platforms faces many barriers to clinical use, such as production scalability and off…
View article: Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation
Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation Open
Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.
View article: A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency Open
View article: A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection Open
View article: Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins Open
View article: Application of a Method for Engineering Multivalent Antibodies to Substantially Enhance Functional affinity of Clinical Trial Anti-SARS-CoV-2 Antibodies
Application of a Method for Engineering Multivalent Antibodies to Substantially Enhance Functional affinity of Clinical Trial Anti-SARS-CoV-2 Antibodies Open
Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 disease. Therapeutic antibodies are being developed that interact with the viral spike proteins to limit viral infection of epithelium. We have a…
View article: A Super-Potent Tetramerized ACE2 Protein Displays Enhanced Neutralization of SARS-CoV-2 Virus Infection
A Super-Potent Tetramerized ACE2 Protein Displays Enhanced Neutralization of SARS-CoV-2 Virus Infection Open
Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising …
View article: Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors
Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors Open
High-affinity TCRs offer the potential to target chemotherapeutic drug-loaded nanoparticles specifically to tumour cells expressing tumour-specific peptides minimising off-target effects.
View article: Shape tracing: An extension of sphere tracing for 3D non-convex collision in protein docking
Shape tracing: An extension of sphere tracing for 3D non-convex collision in protein docking Open
This paper presents an algorithm, similar to implicit
\nsphere tracing, that ray marches 3D non-convex shapes for
\nefficient collision detection. Instead of finding points on the
\nsurface where individual rays strike, an entire shape is …
View article: Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature
Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature Open
Anti-DLL4 VNAR targeted nanoparticles – a novel targeting ligand towards an under-investigated target.
View article: Nietzsche and moral inquiry : posing the question of the value of our moral values
Nietzsche and moral inquiry : posing the question of the value of our moral values Open
The continued presence and importance of Christian moral values in our daily lives, coupled with the fact that faith in Christianity is in continual decline, raises the question as to why having lost faith in Christianity, we have also not…