Adam M. Rochussen
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View article: Actin conformation dynamics precede force generation in cytotoxic T lymphocytes
Actin conformation dynamics precede force generation in cytotoxic T lymphocytes Open
Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent …
View article: Transcriptional adaptation after deletion of <i>Cdc42</i> in primary T cells
Transcriptional adaptation after deletion of <i>Cdc42</i> in primary T cells Open
Cdc42 is a Rho family GTPase known for its central role in cell polarity and cytoskeletal regulation. To understand the role of Cdc42 in polarised secretion from cytotoxic T lymphocytes (CTLs) we used CRISPR/Cas9 gene deletion. Although Cd…
View article: Actin conformation dynamics precede force generation in cytotoxic T lymphocytes
Actin conformation dynamics precede force generation in cytotoxic T lymphocytes Open
Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent …
View article: Dominant negative variants in <i>ITPR3</i> impair T cell Ca2+ dynamics causing combined immunodeficiency
Dominant negative variants in <i>ITPR3</i> impair T cell Ca2+ dynamics causing combined immunodeficiency Open
The importance of calcium (Ca2+) as a second messenger in T cell signaling is exemplified by genetic deficiencies of STIM1 and ORAI1, which abolish store-operated Ca2+ entry (SOCE) resulting in combined immunodeficiency (CID). We report fi…
View article: NFIL3 contributes to cytotoxic T lymphocyte-mediated killing
NFIL3 contributes to cytotoxic T lymphocyte-mediated killing Open
Cytotoxic T lymphocytes (CTLs) are key effectors of the adaptive immune system that recognize and eliminate virally infected and cancerous cells. In naive CD8 + T cells, T-cell receptor (TCR) engagement drives a number of transcriptional, …
View article: Imaging the T-cell receptor: new approaches, new insights
Imaging the T-cell receptor: new approaches, new insights Open
T cells recognize pathogenic antigens via the T-cell antigen receptor (TCR). This protein complex binds to antigen fragments on the surface of antigen-presenting cells. To understand how cellular activation can ensue rapidly from molecular…
View article: Targeting non-coding RNA family members with artificial endonuclease XNAzymes
Targeting non-coding RNA family members with artificial endonuclease XNAzymes Open