Adam McNee
YOU?
Author Swipe
View article: Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcomes
Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcomes Open
Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response were inves…
View article: Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs
Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs Open
Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TR…
View article: Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host
Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host Open
Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response was invest…
View article: Expanding Human Breg for Cellular Therapy in Transplantation: Time for Translation
Expanding Human Breg for Cellular Therapy in Transplantation: Time for Translation Open
Regulatory B cells (Breg) are instrumental in protecting allografts in transplantation. Breg signatures are identified in operationally tolerant human kidney transplant recipients and can predict organ survival and acute rejection. Animal …
View article: A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies
A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies Open
Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large animal host for influenza A, with many physiological, immunological, and anatomi…
View article: Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses
Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses Open
Porcine respiratory disease is multifactorial and most commonly involves pathogen co-infections. Major contributors include swine influenza A (swIAV) and porcine reproductive and respiratory syndrome (PRRSV) viruses. Experimental co-infect…
View article: Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells
Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells Open
Lung tissue-resident memory T cells (TRM) are critical for the local control of viral respiratory tract infections. However, the exact mechanisms of TRM stimulation and maintenance are not fully understood, rendering the induction of prote…
View article: Effect of mucosal adjuvant IL-1β on heterotypic immunity in a pig influenza model
Effect of mucosal adjuvant IL-1β on heterotypic immunity in a pig influenza model Open
T cell responses directed against highly conserved viral proteins contribute to the clearance of the influenza virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses in mice and ferrets…
View article: Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs
Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs Open
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization. We investigated the efficacy of heterologous prime boost immunization with chimpanzee adenovirus (ChAdOx2) and …
View article: Porcine Respiratory Coronavirus as a Model for Acute Respiratory Coronavirus Disease
Porcine Respiratory Coronavirus as a Model for Acute Respiratory Coronavirus Disease Open
In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune respon…
View article: Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding
Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding Open
We have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing the therapeutic potential of monoclonal antibodies (mAbs). In this study we demonstrated …
View article: Simultaneous Infection With Porcine Reproductive and Respiratory Syndrome and Influenza Viruses Abrogates Clinical Protection Induced by Live Attenuated Porcine Reproductive and Respiratory Syndrome Vaccination
Simultaneous Infection With Porcine Reproductive and Respiratory Syndrome and Influenza Viruses Abrogates Clinical Protection Induced by Live Attenuated Porcine Reproductive and Respiratory Syndrome Vaccination Open
The porcine respiratory disease complex (PRDC) is responsible for significant economic losses in the pig industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus are major viral contributors…
View article: Respiratory and Intramuscular Immunization With ChAdOx2-NPM1-NA Induces Distinct Immune Responses in H1N1pdm09 Pre-Exposed Pigs
Respiratory and Intramuscular Immunization With ChAdOx2-NPM1-NA Induces Distinct Immune Responses in H1N1pdm09 Pre-Exposed Pigs Open
There is a critical need to develop superior influenza vaccines that provide broader protection. Influenza vaccines are traditionally tested in naive animals, although humans are exposed to influenza in the first years of their lives, but …
View article: Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding
Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding Open
We have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing the therapeutic potential of monoclonal antibodies (mAbs). In this study we demonstrated …
View article: Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells
Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells Open
We defined naïve, central memory, effector memory and terminally differentiated porcine CD8 T cells and analyzed their phenotype in lymphoid and respiratory tissues after influenza infection or immunization using peptide-MHC tetramers of t…
View article: Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination
Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination Open
The porcine respiratory disease complex (PRDC) is responsible for significant economic losses in the pig industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus are major viral contributors…
View article: Respiratory and intramuscular immunization with ChAdOx2 NPM1-NA induces distinct immune responses in H1N1pdm09 pre-exposed pigs
Respiratory and intramuscular immunization with ChAdOx2 NPM1-NA induces distinct immune responses in H1N1pdm09 pre-exposed pigs Open
There is a critical need to develop superior influenza vaccines that provide broader protection. Influenza vaccines are traditionally tested in naïve animals, although humans are exposed to influenza in the first years of their lives, but …
View article: Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans
Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans Open
[This corrects the article DOI: 10.1371/journal.ppat.1009330.].
View article: Correction: Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs
Correction: Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs Open
Martini, V., B. Paudyal, T. Chrun, A. McNee, M. Edmans, E. Atangana Maze, B. Clark, A. Nunez, G. Dolton, A. Sewell, P. Beverley, R. MacLoughlin, A. Townsend, and E. Tchilian. 2021. Simultaneous aerosol and intramuscular immunization with i…
View article: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans
Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans Open
Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions in both directions. The emergence of the 2009 pandemic H1N1 virus illustrates…
View article: Magnitude and Kinetics of T Cell and Antibody Responses During H1N1pdm09 Infection in Inbred Babraham Pigs and Outbred Pigs
Magnitude and Kinetics of T Cell and Antibody Responses During H1N1pdm09 Infection in Inbred Babraham Pigs and Outbred Pigs Open
We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to the 2009 pandemic H1N1 virus infection. We evaluated the ki…
View article: Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs
Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs Open
A vaccine providing both powerful Ab and cross-reactive T cell immune responses against influenza viruses would be beneficial for both humans and pigs. In this study, we evaluated i.m., aerosol (Aer), and simultaneous systemic and respirat…
View article: Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs
Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs Open
We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to the 2009 pandemic H1N1 virus infection. We evaluated the ki…
View article: Distribution of Droplets and Immune Responses After Aerosol and Intra-Nasal Delivery of Influenza Virus to the Respiratory Tract of Pigs
Distribution of Droplets and Immune Responses After Aerosol and Intra-Nasal Delivery of Influenza Virus to the Respiratory Tract of Pigs Open
Recent evidence indicates that local immune responses and tissue resident memory T cells (TRM) are critical for protection against respiratory infections but there is little information on the contributions of upper and lower respiratory t…
View article: Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs
Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs Open
A vaccine providing both powerful antibody and cross-reactive T cell immune responses against influenza viruses would be beneficial for both humans and pigs. Here we evaluated intramuscular (IM), aerosol (Aer) and simultaneous immunization…
View article: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans
Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans Open
Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions in both directions. The emergence of the 2009 pandemic H1N1 virus illustrates…
View article: Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms
Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms Open
mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus infection. However, questions remain whether small animal models accurately predict efficacy in humans. We have established the pig, a large natural host …
View article: Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs
Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs Open
Recent evidence indicates that local immune responses and tissue resident memory T cells (T RM ) are critical for protection against respiratory infections but there is little information on the contributions of upper and lower respiratory…