Ádám Mechler
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View article: Integrative proteomics and lipidomics reveals dual roles for lipid droplets in the host cell antiviral response
Integrative proteomics and lipidomics reveals dual roles for lipid droplets in the host cell antiviral response Open
Lipid droplets (LDs), once viewed as inert lipid storage sites, are now recognised as dynamic organelles central to cellular signalling and immunity. This study presents a dual-omics approach, integrating proteomics and lipidomics, to inve…
View article: The phospholipid composition of artificial lipid droplets enhances their deliverability and facilitates a broad Biodistribution in vivo and in vitro
The phospholipid composition of artificial lipid droplets enhances their deliverability and facilitates a broad Biodistribution in vivo and in vitro Open
Artificial lipid droplets (aLDs) provide a useful tool to explore the multiple functionalities of intracellular lipid droplets (LDs). In this study we explored the dynamics and potential multidisciplinary applications of these lipid partic…
View article: Metal cross-linking of helical oligoamide nanorods serves as platform for hierarchical nanofibers
Metal cross-linking of helical oligoamide nanorods serves as platform for hierarchical nanofibers Open
Helical $$\upbeta$$ -oligoamides serve as versatile molecular building blocks with the unique ability to maintain stable helical fold and be functionalized by sequence modifications without affecting the folding ability. Fibrous head-to-…
View article: Nano-viscosimetry analysis of membrane disrupting peptide magainin2 interactions with model membranes
Nano-viscosimetry analysis of membrane disrupting peptide magainin2 interactions with model membranes Open
The rapid spread of antibiotic-resistant strains of bacteria has created an urgent need for new alternative antibiotic agents. Membrane disrupting antimicrobial peptides (AMPs): short amino acid sequences with bactericidal and fungicidal a…
View article: Artificial Lipid Droplets Demonstrate a Wide Biodistribution in vivo
Artificial Lipid Droplets Demonstrate a Wide Biodistribution in vivo Open
View article: The reaction of acetamiprid with OH radicals in the environment: a theoretical study
The reaction of acetamiprid with OH radicals in the environment: a theoretical study Open
In the environment, acetamiprid undergoes moderate degradation via hydroxyl radicals, leading to the formation of H-abstraction products.
View article: The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution
The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution Open
Artificial intelligence (AI) platforms have emerged as pivotal tools in genetics and molecular medicine, as in many other fields. The growth in patient data, identification of new diseases and phenotypes, discovery of new intracellular pat…
View article: A strategy for covalent anchoring of self-assembling β<sup>3</sup> oligoamide nanorods to gold surfaces
A strategy for covalent anchoring of self-assembling β<sup>3</sup> oligoamide nanorods to gold surfaces Open
Oligopeptides stand out for their remarkable structural variability, ease of synthesis, and amenability to functionalization, making them exceedingly appealing for crafting functional nanostructured materials. The low metabolic stability o…
View article: The radical scavenging activity of monocaffeoylquinic acids: the role of neighboring hydroxyl groups and pH levels
The radical scavenging activity of monocaffeoylquinic acids: the role of neighboring hydroxyl groups and pH levels Open
Through the hydrogen transfer reaction of adjacent hydroxyl groups, CQAs demonstrate excellent antioxidant activity in aqueous physiological environments.
View article: Reaction of methylene blue with OH radicals in the aqueous environment: mechanism, kinetics, products and risk assessment
Reaction of methylene blue with OH radicals in the aqueous environment: mechanism, kinetics, products and risk assessment Open
Methylene blue in the environment is of moderate concern, depending on the ratio of safe to harmful breakdown products.
View article: The radical scavenging activity of 1-methyl-1,4-dihydronicotinamide: theoretical insights into the mechanism, kinetics and solvent effects
The radical scavenging activity of 1-methyl-1,4-dihydronicotinamide: theoretical insights into the mechanism, kinetics and solvent effects Open
In physiological environments, 1-methyl-1,4-dihydronicotinamide (MNAH), an active center of the nicotinamide coenzyme (NADH), demonstrated significant radical scavenging activity.
View article: Synthesis and computational evaluation of the antioxidant activity of pyrrolo[2,3-<i>b</i>]quinoxaline derivatives
Synthesis and computational evaluation of the antioxidant activity of pyrrolo[2,3-<i>b</i>]quinoxaline derivatives Open
The antioxidant activity of five derivatives of 3-hydroxy-3-pyrroline-2-one was effectively assessed after synthesis.
View article: Computational assessment of the radical scavenging activity of cleomiscosin
Computational assessment of the radical scavenging activity of cleomiscosin Open
Cleomiscosins from traditional medicinal plants are promising radical scavengers in aqueous physiological environments.
View article: Invited Speaker Abstracts
Invited Speaker Abstracts Open
Nature abounds in self-assembling systems that include cell membranes, actin fibres and the flagellum rotor.Nature inspired design attempts to learn from the organizing principles of these structures while introducing novel molecular desig…
View article: Antiradical Activity of Lignans from <i>Cleistanthus sumatranus</i>: Theoretical Insights into the Mechanism, Kinetics, and Solvent Effects
Antiradical Activity of Lignans from <i>Cleistanthus sumatranus</i>: Theoretical Insights into the Mechanism, Kinetics, and Solvent Effects Open
Sumatranus lignans (SL) isolated from Cleistanthus sumatranus have demonstrated bioactivities, e.g., they were shown to exhibit immunosuppressive properties in previous research. Their structure suggests potential antioxidant…
View article: Virally induced lipid droplets are a platform for innate immune signalling complexes
Virally induced lipid droplets are a platform for innate immune signalling complexes Open
Lipid droplets (LDs) are upregulated by host cells in the face of pathogen infection, however, the reason for this phenomenon remains largely unknown. Here, we demonstrate that virally induced LDs house a distinct and dynamic proteome cont…
View article: Feruloylmonotropeins: promising natural antioxidants in <i>Paederia scandens</i>
Feruloylmonotropeins: promising natural antioxidants in <i>Paederia scandens</i> Open
Feruloylmonotropeins (FMTs), derived from Paederia scandens , are expected to be potent radical scavengers in physiological aqueous environments.
View article: The alkoxy radical polymerization of <i>N</i>-vinylpyrrolidone in organic solvents: theoretical insight into the mechanism and kinetics
The alkoxy radical polymerization of <i>N</i>-vinylpyrrolidone in organic solvents: theoretical insight into the mechanism and kinetics Open
The calculations validated the radical polymerization of NVP in organic solvents with propagation rate constants of 10 1 –10 3 M −1 s −1 .
View article: Virally Induced Lipid Droplets are a Platform for Innate Immune Signalling Complexes
Virally Induced Lipid Droplets are a Platform for Innate Immune Signalling Complexes Open
View article: Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications
Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications Open
Nanosilica is a versatile nanomaterial suitable as, e.g., drug carriers in medicine, fillers in polymers, and fertilizer/pesticide carriers and potentially a bioavailable source of silicon in agriculture. The enhanced biological activity o…
View article: The Mechanisms and Kinetics of Radical Scavenging Activity of Edaravone: A Computational Insight
The Mechanisms and Kinetics of Radical Scavenging Activity of Edaravone: A Computational Insight Open
Edaravone (EDV, 3-methyl-1-phenyl-2-pyrazolin-5-one) is a neuroprotective drug that has been used to treat acute stroke caused by cerebral thrombosis and embolism. Studies showed that EDV could be used to treat diseases related to oxidizin…
View article: A Potent Antioxidant Sesquiterpene, Abelsaginol, from <i>Abelmoschus sagittifolius</i>: Experimental and Theoretical Insights
A Potent Antioxidant Sesquiterpene, Abelsaginol, from <i>Abelmoschus sagittifolius</i>: Experimental and Theoretical Insights Open
The sesquiterpenoid compound abelsaginol (AS) was successfully isolated from Abelmoschus sagittifolius for the first time. The compound was identified using NMR and MS data. The antioxidant activity of AS was also eval…
View article: Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods
Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods Open
In this study, the performance of 17 different density functional theory functionals was compared for the calculation of the bond dissociation energy (BDE) values of X−H (X=C, N, O, S) bonds of aromatic compounds. The effect of the size of…
View article: 7-O-Galloyltricetifavan: a promising natural radical scavenger
7-O-Galloyltricetifavan: a promising natural radical scavenger Open
7-O-Galloyltricetifavan ( 7OGT ), a natural flavonoid, is isolated from the leaves of Pithecellobium clypearia . The compound exhibits a variety of biological activities. This study details the evaluation of the HOO • antiradical activity …
View article: Protocol for using artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins
Protocol for using artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins Open
View article: The radical scavenging activity of glycozolidol in physiological environments: a quantum chemical study
The radical scavenging activity of glycozolidol in physiological environments: a quantum chemical study Open
Glycozolidol (GLD), derived from Glycosmis pentaphylla , is predicted to be a good radical scavenger in physiological environments.
View article: Synthesis and evaluation of the antioxidant activity of 3-pyrroline-2-ones: experimental and theoretical insights
Synthesis and evaluation of the antioxidant activity of 3-pyrroline-2-ones: experimental and theoretical insights Open
Derivatives of 3-hydroxy-3-pyrroline-2-one were effectively synthesized via multicomponent reactions and exhibited potential HO˙ radical scavenging activity.
View article: Oxoberberine: a promising natural antioxidant in physiological environments
Oxoberberine: a promising natural antioxidant in physiological environments Open
Oxoberberine (OB), a radical scavenger discovered from Artabotrys thomsonii , is expected to be effective in physiological environments.
View article: Theoretical insights into the antiradical activity and copper-catalysed oxidative damage of mexidol in the physiological environment
Theoretical insights into the antiradical activity and copper-catalysed oxidative damage of mexidol in the physiological environment Open
Mexidol ( MD , 2-ethyl-6-methyl-3-hydroxypyridine) is a registered therapeutic agent for the treatment of anxiety disorders. The chemical structure suggests that MD may also act as an antioxidant. In this study, the hydroperoxyl radical sc…
View article: Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β<sup>3</sup> oligoamide
Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β<sup>3</sup> oligoamide Open
Substituted β 3 oligoamides form a unique self-assembling system where each monomer folds into a helix containing approximately three β 3 amino acids per turn, yielding a geometrically well-defined cylindrical building block that, when N-a…