Adam Meijer
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View article: Comparative evaluation of five rapid PCR platforms for respiratory virus detection
Comparative evaluation of five rapid PCR platforms for respiratory virus detection Open
Background The demand for rapid molecular diagnostics for respiratory viruses has increased substantially. Several point-of-care PCR platforms have become available, yet comparative performance data remain limited. Objectives To evaluate t…
View article: RNA structure modulates Cas13 activity and enables mismatch detection
RNA structure modulates Cas13 activity and enables mismatch detection Open
Cas13 is activated by the hybridization of a CRISPR RNA to a complementary single-stranded RNA protospacer in a target RNA. While Cas13 is not activated by double-stranded RNA in vitro, it robustly targets RNA in cellular environments wher…
View article: 8287519 Occupational microbial health risks in intensive goat farming: airborne microbial exposure, farmers’ respiratory microbiome and fungal sensitization
8287519 Occupational microbial health risks in intensive goat farming: airborne microbial exposure, farmers’ respiratory microbiome and fungal sensitization Open
View article: Integrative mapping of preexisting influenza immune landscapes predicts vaccine response
Integrative mapping of preexisting influenza immune landscapes predicts vaccine response Open
BACKGROUNDPredicting individual vaccine responses is a substantial public health challenge. We developed Immunaut, an open-source, data-driven framework for systems vaccinologists to analyze and predict immunological outcomes across divers…
View article: Evaluation of molecular detection for respiratory syncytial viruses in World Health Organization Europe region laboratories, 2020–2023
Evaluation of molecular detection for respiratory syncytial viruses in World Health Organization Europe region laboratories, 2020–2023 Open
View article: Global update on the susceptibilities of influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2020–2023
Global update on the susceptibilities of influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2020–2023 Open
View article: Influenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24
Influenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24 Open
Introduction Influenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses circulated in Europe in 2023/24, with A(H1N1)pdm09 dominance. First influenza infections in childhood may lead to different vaccine effectiveness (VE) in subsequent years.…
View article: Swine influenza virus surveillance programme pilot to assess the risk for animal and public health, the Netherlands, 2022 to 2023
Swine influenza virus surveillance programme pilot to assess the risk for animal and public health, the Netherlands, 2022 to 2023 Open
Background Swine influenza has a considerable impact on pig populations and poses a pandemic threat to humans. However, little is known about the influenza A viruses circulating among pigs in the Netherlands. Aim We piloted a surveillance …
View article: Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023
Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023 Open
Background Data on economic costs of respiratory syncytial virus (RSV) infections among children in primary care are scarce, although most RSV-infections are managed in this setting. Aim To estimate outpatient costs for RSV-positive childr…
View article: Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023
Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023 Open
Background Zoonotic influenza, including infections with avian and swine influenza A viruses (swIAV), is a notifiable disease in the Netherlands. Human cases infected with swIAV have previously been rarely detected in the Netherlands. Aim …
View article: COVID‐19 Vaccine Effectiveness Against Medically Attended Symptomatic SARS‐CoV‐2 Infection Among Target Groups in Europe, October 2024–January 2025, VEBIS Primary Care Network
COVID‐19 Vaccine Effectiveness Against Medically Attended Symptomatic SARS‐CoV‐2 Infection Among Target Groups in Europe, October 2024–January 2025, VEBIS Primary Care Network Open
We estimated the effectiveness of 2024/25 COVID‐19 vaccination against medically attended SARS‐CoV‐2 infection in Europe, among target groups. We included 3204 patients (8/139 cases vaccinated: 6%; 517/3065 controls vaccinated: 17%) from a…
View article: Human respiratory syncytial virus genetic diversity and lineage replacement in Ireland pre- and post-COVID-19 pandemic
Human respiratory syncytial virus genetic diversity and lineage replacement in Ireland pre- and post-COVID-19 pandemic Open
Human respiratory syncytial virus (HRSV) is a common cause of lower respiratory tract infections globally, and changes in viral epidemiology have been observed in many jurisdictions following the coronavirus disease 2019 (COVID-19) pandemi…
View article: External quality assessment of molecular detection and variant typing of SARS-CoV-2 in European expert laboratories in 2023
External quality assessment of molecular detection and variant typing of SARS-CoV-2 in European expert laboratories in 2023 Open
The COVID-19 pandemic highlighted the importance of laboratory preparedness. Regular monitoring of diagnostic tools via external quality assessments (EQAs) is key to maintaining robust public health response service. We hereby conducted a …
View article: Correction: The performance of a lateral flow SARS-CoV-2 antibody assay and semi-autonomous SARS-CoV-2 antisense and sense RNA fluorescence in situ hybridization assay in a prospective cohort pilot study within a Dutch military population
Correction: The performance of a lateral flow SARS-CoV-2 antibody assay and semi-autonomous SARS-CoV-2 antisense and sense RNA fluorescence in situ hybridization assay in a prospective cohort pilot study within a Dutch military population Open
[This corrects the article DOI: 10.1371/journal.pone.0309091.].
View article: Mycoplasma pneumoniae MLST detected in the upsurge of pneumonia during the 2023 to 2024 winter season in the Netherlands
Mycoplasma pneumoniae MLST detected in the upsurge of pneumonia during the 2023 to 2024 winter season in the Netherlands Open
View article: Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction
Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction Open
Predicting individual vaccine responses remains a significant challenge due to the complexity and variability of immune processes. To address this gap, we developed immunaut , an open-source, data-driven framework implemented as an R packa…
View article: Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24–59 months in The Gambia: a phase 4, open-label, randomised controlled trial
Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24–59 months in The Gambia: a phase 4, open-label, randomised controlled trial Open
The Wellcome Trust, UK National Institute for Health Research, and Chief Scientist Office Scotland.
View article: Evaluation of Molecular Detection for Respiratory Syncytial Viruses in World Health Organization Europe Region Laboratories, 2020-2023
Evaluation of Molecular Detection for Respiratory Syncytial Viruses in World Health Organization Europe Region Laboratories, 2020-2023 Open
View article: COVID-19 Vaccine Effectiveness against Medically Attended Symptomatic SARS-CoV-2 Infection among Target Groups in Europe, October 2024-January 2025, VEBIS Primary Care Network
COVID-19 Vaccine Effectiveness against Medically Attended Symptomatic SARS-CoV-2 Infection among Target Groups in Europe, October 2024-January 2025, VEBIS Primary Care Network Open
View article: The performance of a lateral flow SARS-CoV-2 antibody assay and semi-autonomous SARS-CoV-2 antisense and sense RNA fluorescence in situ hybridization assay in a prospective cohort pilot study within a Dutch military population
The performance of a lateral flow SARS-CoV-2 antibody assay and semi-autonomous SARS-CoV-2 antisense and sense RNA fluorescence in situ hybridization assay in a prospective cohort pilot study within a Dutch military population Open
At the beginning of the COVID-19 pandemic, diagnostic testing was not accessible for mildly ill or asymptomatic individuals. Military operational circumstances exclude the usage of reference laboratory tests. For that reason, at the beginn…
View article: A statistical modelling approach for determining the cause of reported respiratory syndromes from internet-based participatory surveillance when influenza virus and SARS-CoV-2 are co-circulating
A statistical modelling approach for determining the cause of reported respiratory syndromes from internet-based participatory surveillance when influenza virus and SARS-CoV-2 are co-circulating Open
Symptom-only case definitions are insufficient to discriminate COVID-like illness from acute respiratory infection (ARI) or influenza-like illness (ILI), due to the overlap in case definitions. Our objective was to develop a statistical me…
View article: Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection
Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection Open
Background To date, it is still not clear why during the COVID-19 pandemic children generally developed no or milder symptoms compared to adults. As innate immune responses are crucial in the early defense against pathogens, we aimed at pr…
View article: Post-disappearance scenarios: policy implications following the potential disappearance of B/Yamagata lineage influenza viruses
Post-disappearance scenarios: policy implications following the potential disappearance of B/Yamagata lineage influenza viruses Open
The COVID-19 pandemic and related preventive measures reduced influenza virus circulation, notably causing the disappearance of the B/Yamagata lineage of influenza viruses. In this Perspective, we discuss the implications that this develop…
View article: Effectiveness of XBB.1.5 Vaccines Against Symptomatic SARS‐CoV‐2 Infection in Older Adults During the JN.1 Lineage‐Predominant Period, European VEBIS Primary Care Multicentre Study, 20 November 2023–1 March 2024
Effectiveness of XBB.1.5 Vaccines Against Symptomatic SARS‐CoV‐2 Infection in Older Adults During the JN.1 Lineage‐Predominant Period, European VEBIS Primary Care Multicentre Study, 20 November 2023–1 March 2024 Open
We estimated XBB.1.5 vaccine effectiveness (VE) against symptomatic SARS‐CoV‐2 infection among adults aged ≥ 65 years during the 2023/2024 JN.1 lineage‐predominant period in a European multi‐country test‐negative case–control study at prim…
View article: Measuring the impact of influenza vaccination in the Netherlands using retrospective observational primary care, hospitalisation and mortality data
Measuring the impact of influenza vaccination in the Netherlands using retrospective observational primary care, hospitalisation and mortality data Open
We aimed to estimate the impact of influenza vaccination in the Netherlands using general practitioner medical records for 2011-2020. We found that vaccinees had higher consultation rates for influenza-like-illness, acute respiratory infec…
View article: Standardized Phylogenetic Classification of Human Respiratory Syncytial Virus Below the Subgroup Level
Standardized Phylogenetic Classification of Human Respiratory Syncytial Virus Below the Subgroup Level Open
A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV classification on the basis of the challenges and limi…
View article: Human Respiratory Syncytial Virus Genetic Diversity and Lineage Replacement in Ireland pre- and post-COVID-19 pandemic
Human Respiratory Syncytial Virus Genetic Diversity and Lineage Replacement in Ireland pre- and post-COVID-19 pandemic Open
Background Human respiratory syncytial virus (HRSV) is a common cause of lower respiratory tract infections globally. Newly-licensed prophylactic vaccines and monoclonal antibodies are anticipated to alleviate this burden; however, such in…
View article: Corrigendum to “Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: results from the VEBIS primary care test-negative design study, September 2023–January 2024” [Vaccine 42(19) (2024)]
Corrigendum to “Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: results from the VEBIS primary care test-negative design study, September 2023–January 2024” [Vaccine 42(19) (2024)] Open
View article: COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans
COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans Open
Importance In the context of emerging SARS-CoV-2 variants or lineages and new vaccines, it is key to accurately monitor COVID-19 vaccine effectiveness (CVE) to inform vaccination campaigns. Objective To estimate the effectiveness of COVID-…
View article: Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024
Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024 Open