Adam P. Kupinski
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View article: Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant
Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant Open
Botulinum neurotoxin (BoNT) serotype A inhibits neurotransmitter release by cleaving SNAP-25 and represents an established pharmaceutical for treating medical conditions caused by hyperactivity of cholinergic nerves. Oversecretion from non…
View article: Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability
Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability Open
V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single recombination sign…
View article: ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid Open
The activity of type II toxin-antitoxin systems (TA), which are responsible for many important features of bacterial cells, is based on the differences between toxin and antitoxin stabilities. The antitoxin lability results from bacterial …