Adam R. Karpf
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View article: CRISPR Targeting the 5′ Regulatory Region of FOXM1 Will Also Disrupt RHNO1
CRISPR Targeting the 5′ Regulatory Region of FOXM1 Will Also Disrupt RHNO1 Open
View article: RHNO1: at the crossroads of DNA replication stress, DNA repair, and cancer
RHNO1: at the crossroads of DNA replication stress, DNA repair, and cancer Open
View article: PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives
PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives Open
Ovarian cancer is the deadliest gynecologic malignancy. The majority of patients diagnosed with advanced ovarian cancer will relapse, at which point additional therapies can be administered but, for the most part, these are not curative. A…
View article: NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells
NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells Open
Background Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC…
View article: Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate Open
Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
View article: Supplementary Table S2 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Supplementary Table S2 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
DNA methylome sequencing parameters and results.
View article: Data from G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly
Data from G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly Open
G-protein–coupled estrogen receptor 1 (GPER1) has been reported to play a significant role in mediating the rapid estrogen actions in a wide range of normal and cancer cells. G-1 was initially developed as a selective agonist for GPER. How…
View article: Supplementary Table S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Supplementary Table S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Karpf 450K FTE and OSE vs. Bowtell 450K FTE methylomes.
View article: Figure S7 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S7 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Bowtell 450K data principal component analyses (PCA).
View article: Supplementary Table 7 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i>
Supplementary Table 7 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i> Open
Primers used for RT-qPCR
View article: Supplementary Table 5 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i>
Supplementary Table 5 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i> Open
BORIS vs. GALNT14 mRNA expression correlations in TCGA data
View article: Supplementary Table 6 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i>
Supplementary Table 6 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i> Open
New/enhanced CTCF binding sites associated with known genes
View article: Figure S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Methylation of HOX genes in HGSC, FTE, and OSE.
View article: Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate Open
Supplementary Figure 2 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
View article: Figure S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
PAX8 and MSLN methylation in HGSC, FTE, and OSE.
View article: Figure S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Karpf 450K Pearson correlation coefficient analysis.
View article: Supplementary Data from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i>
Supplementary Data from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i> Open
Supplementary Figures 1-9
View article: Supplementary Table S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Supplementary Table S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Karpf HGSC and Patient-matched OSE and FTE Sample Information and Methylation Analyses Performed.
View article: Supplementary Figure 3 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Supplementary Figure 3 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate Open
Supplementary Figure 3 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
View article: Supplementary Table 4 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i>
Supplementary Table 4 from <i>BORIS</i> Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through <i>GALNT14</i> Open
Reactome pathways
View article: Supplementary Table 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
Supplementary Table 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer Open
PDF file - 45K, Table S2. Adverse events observed in the clinical trial.
View article: Figure S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S4 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Methylation of HOX genes in HGSC, FTE, and OSE.
View article: Supplementary Table S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Supplementary Table S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Bowtell 450K FTE (n=7) and HGSC Samples (n=78)
View article: Data from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Data from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate Open
Green tea polyphenols (GTP) have been reported to inhibit DNA methylation in cultured cells. Here, we tested whether oral consumption of GTPs affects normal or cancer-specific DNA methylation in vivo, using mice. Wild-type (WT) and …
View article: Data from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
Data from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer Open
The cancer–testis/cancer germline antigen, NY-ESO-1, is a vaccine target in epithelial ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO-1 is regulated by DNA methylation, we hypothesized that DNA…
View article: Supplementary Table S5 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Supplementary Table S5 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Correlation between Karpf 450K and Karpf Methyl-Seq.
View article: Supplementary Table 1 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
Supplementary Table 1 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer Open
PDF file - 41K, Table S1. Characteristics of patients enrolled in the clinical trial.
View article: Figure S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S1 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
Karpf 450K Pearson correlation coefficient analysis.
View article: Figure S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer
Figure S3 from DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer Open
PAX8 and MSLN methylation in HGSC, FTE, and OSE.
View article: Supplementary Figure 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
Supplementary Figure 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer Open
PDF file - 54K, Figure S2. Recognition of naturally processed NY-ESO-1 antigen by NY-ESO-1 specific T cells, pre- and post-therapy.