Adam R. Lescallette
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View article: Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in <i>Pseudomonas aeruginosa</i>
Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in <i>Pseudomonas aeruginosa</i> Open
Azabicyclene, an azetidine-containing natural product, was identified using quorum-sensing molecules to upregulate expression of a gene cluster highly conserved in the human pathogen Pseudomonas aeruginosa. Mutational studies of the gene c…
View article: Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming
Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming Open
Despite progress, our understanding of psychiatric and neurological illnesses remains poor, at least in part due to the inability to access neurons directly from patients. Currently, there are in vitro models available but significa…
View article: SU102. Genomic Characterization of Human Circulating Monocytes Transdifferentiated Into Neuronal-Like Cells and Its Use for Schizophrenia
SU102. Genomic Characterization of Human Circulating Monocytes Transdifferentiated Into Neuronal-Like Cells and Its Use for Schizophrenia Open
Background: Mounting evidence indicates that schizophrenia is a developmental illness with a strong but still misunderstood genetic background. Even large genome-wide association studies have not been successful at identifying the genetic …
View article: Associating schizophrenia, long non-coding RNAs and neurostructural dynamics
Associating schizophrenia, long non-coding RNAs and neurostructural dynamics Open
Several lines of evidence indicate that schizophrenia has a strong genetic component. But the exact nature and functional role of this genetic component in the pathophysiology of this mental illness remains a mystery. Long non-coding RNAs …