Adam Richardson
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View article: Thianthrenium Salt Mediated Homologative 1,3-Dielectrophilic Activation Strategy for Alkene Difunctionalization
Thianthrenium Salt Mediated Homologative 1,3-Dielectrophilic Activation Strategy for Alkene Difunctionalization Open
The chemical introduction of heteroatoms via alkene difunctionalization (e.g., dihydroxylation, diamination, dihalogenation) is a traditional route to convert abundant olefins into highly functionalized building blocks. While the transform…
View article: Thianthrenium Salt‐Mediated Homologative 1,3‐Dielectrophilic Activation Strategy for Alkene Difunctionalization
Thianthrenium Salt‐Mediated Homologative 1,3‐Dielectrophilic Activation Strategy for Alkene Difunctionalization Open
The chemical introduction of heteroatoms via alkene difunctionalization (e.g., dihydroxylation, diamination, dihalogenation) is a traditional route to convert abundant olefins into highly functionalized building blocks. While the transform…
View article: Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice
Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice Open
Dietary methionine restriction (MetR) promotes metabolic health, and we tested the impact of short durations of MetR on high fat diet (HFD)‐induced metabolic dysfunction with the maintenance of HFD. Male C57BL/6J mice were fed HFD from 10 …
View article: Cover Feature: Thianthrenium Salt Mediated Homologative 1,3‐Dielectrophilic Activation Strategy for Alkene Difunctionalization
Cover Feature: Thianthrenium Salt Mediated Homologative 1,3‐Dielectrophilic Activation Strategy for Alkene Difunctionalization Open
View article: <p>From Access to use: Recovering the Original Meaning of Florida's Amendment 7</p>
From Access to use: Recovering the Original Meaning of Florida's Amendment 7 Open
View article: Abortion, Originalism, and the Privacy Clause: What the Supreme Court of Florida Got Wrong in <i>Planned Parenthood v. State</i>
Abortion, Originalism, and the Privacy Clause: What the Supreme Court of Florida Got Wrong in <i>Planned Parenthood v. State</i> Open
View article: Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 Open
The COVID-19 pandemic has accelerated the need to identify new antiviral therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds similar to Remde…
View article: The Originalist Case for Why the Florida Constitution's Right of Privacy Protects the Right to an Abortion
The Originalist Case for Why the Florida Constitution's Right of Privacy Protects the Right to an Abortion Open
View article: Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12
Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12 Open
The COVID-19 pandemic has accelerated the need to identify new therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds similar to Remdesivir (RDV…
View article: microRNA‐184 is induced by store‐operated calcium entry and regulates early keratinocyte differentiation
microRNA‐184 is induced by store‐operated calcium entry and regulates early keratinocyte differentiation Open
Extracellular calcium (Ca 2+ ) and store‐operated Ca 2+ entry (SOCE) govern homoeostasis in the mammalian epidermis. Multiple microRNAs (miRNA) also regulate epidermal differentiation, and raised external Ca 2+ modulates the expression of …
View article: MicroRNA-184 - An Ally in Calcium Signalling in the Skin
MicroRNA-184 - An Ally in Calcium Signalling in the Skin Open
The skin provides a protective barrier against environmental, mechanical and microbial assault throughout life. Extracellular calcium (Ca2+) regulates the behavior of keratinocytes, the cells that form the epidermal layer of the skin. Calc…
View article: MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology Open
The epidermis is vitally important in protecting the organism from environmental insults. Consisting of dynamic outer strata of keratinocytes that terminally differentiate from basal keratinocytes stem cells (KSC), the epidermis is maintai…
View article: Micro <scp>RNA</scp> ‐184 and its long noncoding <scp>RNA</scp> sponge urothelial carcinoma associated 1 are induced in wounded keratinocytes in a store‐operated calcium entry‐dependent manner
Micro <span>RNA</span> ‐184 and its long noncoding <span>RNA</span> sponge urothelial carcinoma associated 1 are induced in wounded keratinocytes in a store‐operated calcium entry‐dependent manner Open
There remains a significant need for therapeutic interventions for wound healing as the clinical and socioeconomic challenges presented by the ageing population and associated rise in non-healing wounds persist, exerting enormous pressure …
View article: Temporal order dynamically modulates the interaction between ground suppression and top-down inhibition.
Temporal order dynamically modulates the interaction between ground suppression and top-down inhibition. Open
View article: microRNA-184 and Its lncRNA Sponge UCA1 are Induced in Wounded Keratinocytes in a Store-Operated Calcium Entry-Dependent Manner
microRNA-184 and Its lncRNA Sponge UCA1 are Induced in Wounded Keratinocytes in a Store-Operated Calcium Entry-Dependent Manner Open
Emerging evidence implicates microRNAs (miRNA) in the regulation of keratinocyte migration. However, the putative roles of microRNA-184 (miR-184) in keratinocyte migration have not been examined. Here, we show that miR-184 expression was e…
View article: Microrna-184 is Induced by Store-Operated Calcium Entry and Regulates Early Keratinocyte Differentiation
Microrna-184 is Induced by Store-Operated Calcium Entry and Regulates Early Keratinocyte Differentiation Open
Extracellular calcium (Ca 2+ ) and store-operated Ca 2+ entry (SOCE) govern homeostasis in the mammalian epidermis. Multiple microRNAs (miRNA) also regulate epidermal differentiation, and raised external Ca 2+ modulates the expression of s…
View article: Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan
Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan Open
View article: Correction for Fogal et al., “Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation”
Correction for Fogal et al., “Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation” Open
Author(s): Fogal, Valentina; Richardson, Adam D; Karmali, Priya P; Scheffler, Immo E; Smith, Jeffrey W; Ruoslahti, Erkki
View article: Gsk3 is a metabolic checkpoint regulator in B cells
Gsk3 is a metabolic checkpoint regulator in B cells Open
View article: Suppression of PGC-1a Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma
Suppression of PGC-1a Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma Open
View article: Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma
Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma Open
Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induc…
View article: Nutrient stress revamps cancer cell metabolism
Nutrient stress revamps cancer cell metabolism Open