Adrian Shuttleworth
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View article: Inhibition of Platelet‐Derived Growth Factor Receptor Signaling Regulates Oct4 and Nanog Expression, Cell Shape, and Mesenchymal Stem Cell Potency
Inhibition of Platelet‐Derived Growth Factor Receptor Signaling Regulates Oct4 and Nanog Expression, Cell Shape, and Mesenchymal Stem Cell Potency Open
Defining the signaling mechanisms that regulate the fate of adult stem cells is an essential step toward their use in regenerative medicine. Platelet-derived growth factor receptor (PDGFR) signaling plays a crucial role in specifying mesen…
View article: Defining Elastic Fiber Interactions by Molecular Fishing
Defining Elastic Fiber Interactions by Molecular Fishing Open
Deciphering interacting networks of the extracellular matrix is a major challenge. We describe an affinity purification and mass spectrometry strategy that has provided new insights into the molecular interactions of elastic fibers, essent…
View article: Differential Regulation of Elastic Fiber Formation by Fibulin-4 and -5
Differential Regulation of Elastic Fiber Formation by Fibulin-4 and -5 Open
View article: Fibulin-5 interacts with fibrillin-1 molecules and microfibrils
Fibulin-5 interacts with fibrillin-1 molecules and microfibrils Open
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted i…
View article: Structural Basis of Type VI Collagen Dimer Formation
Structural Basis of Type VI Collagen Dimer Formation Open
We have determined the interactive sites required for dimer formation in type VI collagen. Despite the fact that type VI collagen is a heterotrimer composed of alpha1(VI), alpha2(VI), and alpha3(VI) chains, the formation of dimers is deter…
View article: Three‐dimensional aggregates of human dermal fibroblasts and keratinocytes act as an <i>in vitro</i> model for the dermal‐epidermal junction of skin
Three‐dimensional aggregates of human dermal fibroblasts and keratinocytes act as an <i>in vitro</i> model for the dermal‐epidermal junction of skin Open
View article: The α1(VIII) and α2(VIII) Chains of Type VIII Collagen Can Form Stable Homotrimeric Molecules
The α1(VIII) and α2(VIII) Chains of Type VIII Collagen Can Form Stable Homotrimeric Molecules Open
Type VIII collagen is a short chain collagen. Two chains have been described, α1(VIII) and α2(VIII), but the chain composition of type VIII collagen is far from resolved. To address this question, we have expressed full-length α1(VIII) and…