Adam J. Singer
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View article: Factors Associated With Persistent Symptoms Following Mild Traumatic Brain Injury
Factors Associated With Persistent Symptoms Following Mild Traumatic Brain Injury Open
IMPORTANCE Traumatic brain injury (TBI) is a common presentation in which it is clinically difficult at presentation to identify patients at risk for persistent symptoms, defined as lasting longer than 30 days. Few studies report the time …
View article: A Host-Protein Test for Differentiating Bacterial From Viral Infection: Diagnostic Accuracy in Elderly Patients
A Host-Protein Test for Differentiating Bacterial From Viral Infection: Diagnostic Accuracy in Elderly Patients Open
MMBV demonstrated high diagnostic accuracy in older adults, supporting its potential to optimize antibiotic use in this population. Further studies are needed to evaluate real-world utility.
View article: Clinical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay
Clinical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay Open
Background High-sensitivity cardiac troponin (hs-cTn) assays performed in the central laboratory have long turnaround times. This study evaluates the clinical performance of a novel bedside point-of-care (POC) hs-cTnI assay (i-STAT® hs-TnI…
View article: Comparison of Regional Wall Motion Abnormalities in STEMI(+) vs. STEMI(-) Occlusion Myocardial Infarction
Comparison of Regional Wall Motion Abnormalities in STEMI(+) vs. STEMI(-) Occlusion Myocardial Infarction Open
Location of RWMA was well-correlated with ECG findings regardless of the presence or absence of STEMI criteria. Prospective study is warranted to determine the utility of echocardiography in the detection of STEMI(-) OMI.
View article: Effect of host‐protein test (<scp>TRAIL</scp>/<scp>IP</scp>‐10/<scp>CRP</scp>) on antibiotic prescription and emergency department or urgent care center return visits: The <scp>JUNO</scp> pilot randomized controlled trial
Effect of host‐protein test (<span>TRAIL</span>/<span>IP</span>‐10/<span>CRP</span>) on antibiotic prescription and emergency department or urgent care center return visits: The <span>JUNO</span> pilot randomized controlled trial Open
Objectives Determining etiology for adults with symptoms of lower respiratory tract infection (LRTI) is challenging. MeMed BV (MMBV), an FDA‐cleared blood test, computationally integrates the levels of three host proteins to differentiate …
View article: Machine learning to optimize use of natriuretic peptides in the diagnosis of acute heart failure
Machine learning to optimize use of natriuretic peptides in the diagnosis of acute heart failure Open
Aims B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) testing are guideline-recommended to aid in the diagnosis of acute heart failure. Nevertheless, the diagnostic performance of these biomarker…
View article: The use of <scp>TENS</scp> for the treatment of back pain in the emergency department: A randomized controlled trial
The use of <span>TENS</span> for the treatment of back pain in the emergency department: A randomized controlled trial Open
Objective Back pain is one of the most common complaints in the emergency department (ED). Since current pharmacological treatments for back pain are often suboptimal, a multimodal approach that includes nonpharmacological modalities has p…
View article: 514 Physics-based Deep Learning Models for Accurate Triage of Burn Wounds Using a Terahertz Spectral Scanner
514 Physics-based Deep Learning Models for Accurate Triage of Burn Wounds Using a Terahertz Spectral Scanner Open
Introduction The formation of edema and the dynamic nature of the zone of stasis, surrounding the zone of coagulation, of a burn are mainly responsible for inaccuracies in burn delineation. Today, burn triage is still based on visual and t…
View article: Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns
Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns Open
BBD was demonstrated to be safe and effective in children. Its use lead to a shorter time to complete eschar removal, a reduction in excisional surgery and non-inferior cosmesis and function results as compared to SOC eschar removal method…
View article: Reepithelialization of partial thickness porcine burns treated with silver sulfadiazine, triple antibiotic or petrolatum.
Reepithelialization of partial thickness porcine burns treated with silver sulfadiazine, triple antibiotic or petrolatum. Open
Topical antibiotic application and occlusive dressings stand as the current standard of care for partial thickness burn (PTB) treatment. Silver sulfadiazine (SSD) is the most widely used topical antimicrobial agent for acute burn managemen…
View article: Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-Of Concept Clinical Studies on the First 22 Tumors
Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-Of Concept Clinical Studies on the First 22 Tumors Open
Background/Objectives: Basal cell carcinoma (BCC), the most prevalent form of human cancer, is traditionally treated by surgical and alternative destructive or topical chemical means, each with its advantages, challenges, and drawbacks. We…
View article: Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-of Concept Clinical Studies on the First 22 Tumors
Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-of Concept Clinical Studies on the First 22 Tumors Open
Background/Objectives: Basal cell carcinoma (BCC), the most prevalent form of human cancer, is traditionally treated by surgical and alternative destructive or topical chemical means, each with its advantages, challenges and drawbacks. We …
View article: A physician-nurse team adjacent to triage shortens length of stay and left-without-being-seen rates
A physician-nurse team adjacent to triage shortens length of stay and left-without-being-seen rates Open
Objective: Staffing significantly influences emergency department (ED) throughput; however, there is a shortage of registered nurses (RNs), impacting ED flow and crowding. Non-RN providers, like licensed practical nurses (LPNs), could pote…
View article: Recovery resources for college students: Leveraging web scraping to unveil current estimates.
Recovery resources for college students: Leveraging web scraping to unveil current estimates. Open
On-campus services to support recovery have greatly expanded since previous estimates, but gaps may exist in the services provided by these programs. By providing an updated estimate and examining service uniformity, this study can aid in …
View article: Design and rationale for REVERXaL: A real-world study of patients with factor Xa inhibitor–associated major bleeds
Design and rationale for REVERXaL: A real-world study of patients with factor Xa inhibitor–associated major bleeds Open
gov; unique identifier: NCT06147830.
View article: 810 Development of a Porcine Burn Wound Model
810 Development of a Porcine Burn Wound Model Open
Introduction Deep partial thickness burns generally require more than 2-3 weeks to heal often resulting in hypertrophic scarring and patient morbidity. Because the skin of pigs most closely resembles that of humans, the pig is often used a…
View article: RECURRENT FALLS IN OLDER ADULTS ARE ASSOCIATED WITH MORTALITY AND HOSPITALIZATION
RECURRENT FALLS IN OLDER ADULTS ARE ASSOCIATED WITH MORTALITY AND HOSPITALIZATION Open
Annually, 1 in 4 older adults fall and roughly half have a second fall within 6 months. We studied 57 hospitals in the TriNetX Network. We included all older adults discharged home from the emergency department (ED) after a fall in 2022 fo…
View article: Radiographic cervical spine injury patterns in admitted blunt trauma patients with and without prehospital spinal motion restriction
Radiographic cervical spine injury patterns in admitted blunt trauma patients with and without prehospital spinal motion restriction Open
Objectives Selective prehospital cervical spine motion restriction (C-SMR) following blunt trauma has increasingly been used by emergency medical service (EMS) providers. We determined rates of prehospital C-SMR and concomitant radiographi…
View article: Treatment of Factor-Xa Inhibitor-associated Bleeding with Andexanet Alfa or 4 Factor PCC: A Multicenter Feasibility Retrospective Study
Treatment of Factor-Xa Inhibitor-associated Bleeding with Andexanet Alfa or 4 Factor PCC: A Multicenter Feasibility Retrospective Study Open
Background: There are no randomized trials comparing andexanet alfa and 4 factor prothrombin complex concentrate (4F-PCC) for the treatment of factor Xa inhibitor (FXa-I)-associated bleeds, and observational studies lack important patient …
View article: The Association between Emergency Department Length of Stay and In-Hospital Mortality in Older Patients Using Machine Learning: An Observational Cohort Study
The Association between Emergency Department Length of Stay and In-Hospital Mortality in Older Patients Using Machine Learning: An Observational Cohort Study Open
The association between emergency department (ED) length of stay (EDLOS) with in-hospital mortality (IHM) in older patients remains unclear. This retrospective study aims to delineate the relationship between EDLOS and IHM in elderly patie…
View article: Bromelain‐based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long‐term outcomes
Bromelain‐based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long‐term outcomes Open
In 2012 the European Medicines Agency approved a pineapple stem‐derived Bromelain‐based debridement concentrate of proteolytic enzymes (NexoBrid®, MediWound Ltd, Yavne, Israel) for adult deep burns. Over 10 000 patients have been successfu…
View article: Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study
Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study Open
Introduction Hyperkalaemia is common, life-threatening and often requires emergency department (ED) management; however, no standardised ED treatment protocol exists. Common treatments transiently reducing serum potassium (K + ) (including…
View article: 764 Comparison of Topical Silver Sulfadiazine and Triple Antibiotic Ointment in a Porcine PT Burn Model
764 Comparison of Topical Silver Sulfadiazine and Triple Antibiotic Ointment in a Porcine PT Burn Model Open
Introduction The standard of care for partial thickness burns is topical antibiotics or occlusive dressing. Silver Sulfadiazine (SSD) emerged at a time of burn wound infection and sepsis prevalence and is now the most used topical worldwid…
View article: Longitudinal Chest X-ray Scores and their Relations with Clinical Variables and Outcomes in COVID-19 Patients
Longitudinal Chest X-ray Scores and their Relations with Clinical Variables and Outcomes in COVID-19 Patients Open
Background: This study evaluated the temporal characteristics of lung chest X-ray (CXR) scores in COVID-19 patients during hospitalization and how they relate to other clinical variables and outcomes (alive or dead). Methods: This is a ret…