Adarsh Shankar
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View article: Diversified legume-oilseed cropping system for synergistic enhancement of yield and water use efficiency in rainfed areas of semi-arid tropics
Diversified legume-oilseed cropping system for synergistic enhancement of yield and water use efficiency in rainfed areas of semi-arid tropics Open
This study explores the development of diversified legume-oilseed cropping systems aimed at enhancing yield and water-use efficiency in rainfed areas of semi-arid tropics. Dryland agriculture, often limited by mono-cropping practices and e…
View article: Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation
Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation Open
Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent determinant of ICH patient outcomes, making clot resolution a primary goal of clin…
View article: Vascular mimicry in glioblastoma following anti-angiogenic and anti-20-HETE therapies.
Vascular mimicry in glioblastoma following anti-angiogenic and anti-20-HETE therapies. Open
Glioblastoma (GBM) is one hypervascular and hypoxic tumor known among solid tumors. Antiangiogenic therapeutics (AATs) have been tested as an adjuvant to normalize blood vessels and control abnormal vasculature. Evidence of relapse exempli…
View article: HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model
HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model Open
Distant metastasis is the primary cause of death in the majority of the cancer types. Recently, much importance has been given to tumor microenvironment (TME) in the development of invasive malignant tumors, as well as the metastasis poten…
View article: Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models
Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models Open
Glioblastoma (GBM) is a hypervascular primary brain tumor with poor prognosis. HET0016 is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth. Therefore, to explore novel treatments, we have generate…
View article: Targeting Bone Marrow to Potentiate the Anti-Tumor Effect of Tyrosine Kinase Inhibitor in Preclinical Rat Model of Human Glioblastoma
Targeting Bone Marrow to Potentiate the Anti-Tumor Effect of Tyrosine Kinase Inhibitor in Preclinical Rat Model of Human Glioblastoma Open
Antiangiogenic agents caused paradoxical increase in pro-growth and pro-angiogenic factors and caused tumor growth in glioblastoma (GBM). It is hypothesized that paradoxical increase in pro-angiogenic factors would mobilize Bone Marrow Der…
View article: Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma
Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma Open
HET0016 is capable of controlling tumor growth and migration, but these effects are dependent on the timing of drug administration. The addition of HET0016 to vatalanib may attenuate the unwanted effect of vatalanib.
View article: Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments
Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments Open
Bone marrow derived cells (BMDCs) have been shown to contribute in the tumor development. In vivo animal models to investigate the role of BMDCs in tumor development are poorly explored. We established a novel chimeric mouse model using as…
View article: Anti-VEGFR2 Driven Nuclear Translocation of VEGFR2 and Acquired Malignant Hallmarks are Mutation Dependent in Glioblastoma
Anti-VEGFR2 Driven Nuclear Translocation of VEGFR2 and Acquired Malignant Hallmarks are Mutation Dependent in Glioblastoma Open
Study suggests that AAT- induced molecular and phenotypic alterations in tumor cells are associated with mutation status and are responsible for aggressive tumor growth. Therefore, mutation status of the tumor in GBM patients should be tak…
View article: ANGI-01NANONIZATION OF HET0016 IMPROVED THE CONTROL OF GMB IN RAT MODEL
ANGI-01NANONIZATION OF HET0016 IMPROVED THE CONTROL OF GMB IN RAT MODEL Open
N-hydroxy-N'-(4-butyl-2 methylphenyl) formamidine (HET0016) has been reported to be a highly selective inhibitor of 20-hydroxy arachidonic acid (20-HETE) synthesis that involves enzymes of the cytochrome P450, family 4, subfamily A (CYP4A)…