Adejoke Y. Onaolapo
YOU?
Author Swipe
View article: Possible Synergistic Modulation of Hormonal Balance and Ovarian Structure by Clomiphene–Letrozole Co-Administration in a Rodent Model of Hyperandrogenism
Possible Synergistic Modulation of Hormonal Balance and Ovarian Structure by Clomiphene–Letrozole Co-Administration in a Rodent Model of Hyperandrogenism Open
Infertility, defined as the inability to achieve pregnancy after 12 months of unprotected intercourse, is a major reproductive health concern. In females, hyperandrogenism often contributes to polycystic ovarian syndrome (PCOS), a leading …
View article: Phenytoin or Spironolactone Intervention Counteracts 5-Fluorouracil–Induced Alopecia in Rats by Suppressing Oxidative Stress and Inflammation While Promoting Collagen Synthesis
Phenytoin or Spironolactone Intervention Counteracts 5-Fluorouracil–Induced Alopecia in Rats by Suppressing Oxidative Stress and Inflammation While Promoting Collagen Synthesis Open
Chemotherapy-induced alopecia (CIA) remains one of the most distressing side-effects of cancer therapy, and it often results from oxidative stress and follicular injury. This study investigated the potential mitigating effects of oral phen…
View article: Neurocognitive Sequelae of Childhood Malaria: An Overlooked Determinant of Africa’s Economic Productivity
Neurocognitive Sequelae of Childhood Malaria: An Overlooked Determinant of Africa’s Economic Productivity Open
Malaria remains one of Africa’s most persistent public-health challenges, but its hidden legacy extends far beyond fever and mortality. However, beyond its acute clinical manifestations, malaria has a more insidious and enduring impact on …
View article: Decoding Malaria: An African Perspective of the Journey from Microscopy to Genomics
Decoding Malaria: An African Perspective of the Journey from Microscopy to Genomics Open
Malaria remains one of the most pressing public health challenges in Africa, a continent that bears a significant percentage of the global malaria morbidity and mortality. From the earliest microscopic discoveries of Plasmodium to the era …
View article: Behavioural, Biochemical, and Cerebral Histomorphological Effects of Aqueous Extract of Datura stramonium L. Leaves in Rats
Behavioural, Biochemical, and Cerebral Histomorphological Effects of Aqueous Extract of Datura stramonium L. Leaves in Rats Open
View article: Effects of Post-Conceptional Melatonin on Cerebral Cortex Alterations in Offspring of Prenatal Valproate-exposed Wistar Rats
Effects of Post-Conceptional Melatonin on Cerebral Cortex Alterations in Offspring of Prenatal Valproate-exposed Wistar Rats Open
The effects of post-conceptional melatonin administration on prenatal-sodium valproate (SV)- induced changes in behaviour and cerebral cortex histomorphology in rats were examined in this study. Twenty-five rats (150–200 g) were mated with…
View article: Assessment of the Effects of Muira Puama Root Extract on Biochemical Indices, and Testicular Histomorphology in Cyclophosphamide-treated Rats
Assessment of the Effects of Muira Puama Root Extract on Biochemical Indices, and Testicular Histomorphology in Cyclophosphamide-treated Rats Open
Cyclophosphamide (CYP), a commonly used anticancer drug, is limited in its therapeutic application by gonadotoxic effects driven by oxidative stress and inflammation. This study investigated the protective role of Muira puama (MP) extract …
View article: Human-dose equivalent 5-fluorouracil triggers a pathophysiological cascade of neuroinflammation, cortical remodeling, and behavioural disruption in Wistar rats.
Human-dose equivalent 5-fluorouracil triggers a pathophysiological cascade of neuroinflammation, cortical remodeling, and behavioural disruption in Wistar rats. Open
5-Fluorouracil (5 FU) is an antimetabolite widely used in cancer chemotherapy. Despite its central role in many anticancer regimens information on its potential effects on the central nervous system (CNS) remains limited. This study invest…
View article: Pentazocine exposure Elicits Motor-social, Neurochemical, and Neuromorphological Deviations in the Cerebellum of Juvenile Male BALB/c Mice
Pentazocine exposure Elicits Motor-social, Neurochemical, and Neuromorphological Deviations in the Cerebellum of Juvenile Male BALB/c Mice Open
Pentazocine is an opioid used as an analgesic for treating moderate or severe pain. Its abusive use can trigger numerous deleterious effects. We examined the impact of pentazocine administration on the cerebellum of juvenile male mice, foc…
View article: Cholecalciferol Ameliorates Cyclophosphamide-induced Behavioural Toxicities in Wistar Rats
Cholecalciferol Ameliorates Cyclophosphamide-induced Behavioural Toxicities in Wistar Rats Open
Cholecalciferol (Vitamin D 3) is a dietary supplement that has been shown to play crucial roles in brain development, immune regulation, neurotransmission and neuroprotection. While there are reports that it influences cognition and mental…
View article: Quercetin Mitigates Aluminium Chloride-Induced Neurotoxicity by Modulating Oxidative Stress, Neuroinflammation, and Neurotransmitter Dysregulation in Rats
Quercetin Mitigates Aluminium Chloride-Induced Neurotoxicity by Modulating Oxidative Stress, Neuroinflammation, and Neurotransmitter Dysregulation in Rats Open
Memory impairment, characterized by reduced ability to recall facts, information, and experiences, is increasingly recognized as a major public health concern. This trend is largely driven by the rising prevalence of age-related cognitive …
View article: Induced-hyperandrogenism in female rats: assessing possible modulation of neurobehavioural and neurotransmitter changes following clomiphene/letrozole intervention
Induced-hyperandrogenism in female rats: assessing possible modulation of neurobehavioural and neurotransmitter changes following clomiphene/letrozole intervention Open
Hyperandrogenism is the excessive production of androgenic hormones resulting in infertility in a number of women. While letrozole and clomiphene citrate have been used to increase chances of achieving pregnancy, their effects on the brain…
View article: Effect of melatonin on hematological indices in cyclophosphamide induced hematotoxicity in mice
Effect of melatonin on hematological indices in cyclophosphamide induced hematotoxicity in mice Open
Background: Cyclophosphamide use is often limited by associated hematotoxicity. This study investigated the effects of melatonin on haematological indices in cyclophosphamide-induced hematotoxicity in mice. Methods: Ninety mice weighing be…
View article: Dietary zinc protects against methotrexate-induced neurotoxicity in rats via modulation of oxidative stress, inflammation and neuronal energy metabolism
Dietary zinc protects against methotrexate-induced neurotoxicity in rats via modulation of oxidative stress, inflammation and neuronal energy metabolism Open
Background Increasing incidence of cancers and cancer chemotherapy-induced neurotoxicities makes it imperative to research compounds with neuroprotective potential that can do not impede therapy. Objective To examine the effect of dietary …
View article: Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity
Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity Open
Background Quercetin’s antioxidative properties make it of potential benefit in many clinical conditions where oxidative stress is implicated in the pathological processes. Objectives To investigate the possible protective effects of querc…
View article: Graded effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, brain markers of oxidative stress, and markers of inflammation in mice
Graded effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, brain markers of oxidative stress, and markers of inflammation in mice Open
Background:Controversies concerning the safety of sodium benzoate/ascorbic acid combination have remained grounds for continued scientific investigations. However, there is a dearth of scientific literature on its effect on the brain. This…
View article: Prepubertal continuous dietary folate fortification enhances brain function of adult mice by modulating antioxidant status, inflammation and brain neurotransmitter levels
Prepubertal continuous dietary folate fortification enhances brain function of adult mice by modulating antioxidant status, inflammation and brain neurotransmitter levels Open
Background There is a growing body of knowledge in support of the beneficial effects of folic acid supplementation. However, while ample evidence exists concerning beneficial effects on growth and haematologic parameters, possible effects …
View article: Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation
Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammation Open
View article: Substance use and substance use disorders in Africa: An epidemiological approach to the review of existing literature
Substance use and substance use disorders in Africa: An epidemiological approach to the review of existing literature Open
The relationship between man and substances that have abuse potentials, and whose use has been associated with the development or progression of substance use disorders has continued to evolve in terms of geography, economic implications, …
View article: Role of Gabanergic and, or Serotonergic in the Anti-seizure Activity of Methanol Extract of Crinum jagus (J. Thomps) in Experimental Mice
Role of Gabanergic and, or Serotonergic in the Anti-seizure Activity of Methanol Extract of Crinum jagus (J. Thomps) in Experimental Mice Open
Objective: Crinum jagus is used in traditional African medicine in the treatment of epilepsy, pain and inflammations.
Methods: Anticonvulsant activity was investigated using picrotoxin (PCT) and strychnine (STR) tests in experimental para…
View article: A Review of the Impact of Testosterone on Brain and Aging-related Decline in Brain Behavioural Function
A Review of the Impact of Testosterone on Brain and Aging-related Decline in Brain Behavioural Function Open
The hormone testosterone is known to affect a variety of functions in thebody, a number of which are related to behaviour, and preservation of brain neuronalintegrity. Along this line, certain experimental evidences suggest that testostero…
View article: Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment
Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment Open
Schizophrenia is a mental health disorder that occurs worldwide, cutting across cultures, socioeconomic groups, and geographical barriers. Understanding the details of the neurochemical basis of schizophrenia, factors that contribute to it…
View article: Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule
Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule Open
The versatility of glutamate as the brain's foremost excitatory neurotransmitter and modulator of neurotransmission and function is considered common knowledge. Years of research have continued to uncover glutamate's effects and roles in s…
View article: The potential toxicity of food-added sodium benzoate in mice is concentration-dependent
The potential toxicity of food-added sodium benzoate in mice is concentration-dependent Open
Sodium benzoate (NaB) is a versatile food preservative that has also found some applications in the treatment of medical disorders. However, till date, its possible widespread effects on the body are not well studied. We examined the likel…
View article: Anxiogenic, memory-impairing, pro-oxidant and pro-inflammatory effects of sodium benzoate in the mouse brain
Anxiogenic, memory-impairing, pro-oxidant and pro-inflammatory effects of sodium benzoate in the mouse brain Open
Objective: Sodium benzoate (NaB), a commonly used food additive, is effective in preventing deterioration and/or spoilage of foods and drinks. While there have been reports suggesting its potential use as an adjunct in schizophrenia manage…
View article: Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders Open
Glutamate’s role as the major excitatory neurotransmitter of the mammalian central nervous system requires that its brain concentrations be kept tightly-controlled. However, in hepatic encephalopathy resulting from liver dysfunction; disru…
View article: Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress
Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress Open
Cucumeropsis mannii (CM) belongs to the melon family and is native to West Africa. There is a paucity of information on its medicinal or nutraceutical potential. Here, we examined the impact of CM in mice that were treated with a normal or…
View article: Prevalence of Multi-Drug Resistant Tuberculosis among Tuberculosis Patients Attending Chest Clinics in Osun-State, Nigeria
Prevalence of Multi-Drug Resistant Tuberculosis among Tuberculosis Patients Attending Chest Clinics in Osun-State, Nigeria Open
Background: The development of multidrug-resistant tuberculosis (MDR-TB) poses a considerable threat to tuberculosis control programmes in Nigeria. There is an increase in the prevalence of MDR-TB worldwide both among new tuberculosis case…
View article: Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders
Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders Open
Melatonin is a multifunctional signalling molecule that is secreted by the mammalian pineal gland, and also found in a number of organisms including plants and bacteria. Research has continued to uncover an ever-increasing number of proces…
View article: An Investigation of the Anti-Parkinsonism Potential of Co-enzyme Q10 and Co-enzyme Q10 /Levodopa-carbidopa Combination in Mice
An Investigation of the Anti-Parkinsonism Potential of Co-enzyme Q10 and Co-enzyme Q10 /Levodopa-carbidopa Combination in Mice Open
Background: Despite decades of research, neurodegenerative disorders like Parkinson’s disease remain a leading cause of disability worldwide, due to the insufficient reduction of disease burden by available medications. Recently, the benef…