Abdulhafez Selim
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View article: Genomic surveillance and evolution of co-circulating avian influenza H5N1 and H5N8 viruses in Egypt, 2022–2024
Genomic surveillance and evolution of co-circulating avian influenza H5N1 and H5N8 viruses in Egypt, 2022–2024 Open
For over two decades, avian influenza virus (AIV) has significantly impacted the Egyptian poultry population, with multiple subtypes and genotypes contributing to significant economic and agricultural losses. As part of an ongoing national…
View article: Impact of climate classification on evapotranspiration variability in arid regions of Saudi Arabia
Impact of climate classification on evapotranspiration variability in arid regions of Saudi Arabia Open
Water resource management in dry climates depends on an awareness of evapotranspiration variability. In this work, precipitation (Pr, mm/year) and air temperature (T °C) over Saudi Arabia (KSA) were extracted using long-term climate data (…
Synthesis, molecular docking, and biological investigations of new pyrazolone chalcones Open
Biological investigations of new pyrazolone chalcones.
High-dose dexamethasone versus prednisone as first-line therapy in newly diagnosed immune thrombocytopenic purpura in children Open
Background Immune thrombocytopenia (ITP) represents one of the most common acquired immune-mediated bleeding disorders observed in pediatric populations. The aim of this work was to compare the results of high-dose dexamethasone (HDD) and …
View article: Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles
Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles Open
To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes. We identified biallelic deleterious variants in 6 genes,…
The Role of PRAME in Malignant Melanoma From Biomarker to Therapeutic Target Open
Malignant melanoma a highly aggressive form of skin cancer originating from melanocytes presents challenges in clinical management due to its propensity for metastasis and therapy resistance
Genetic heterogeneity of chicken anemia virus isolated in selected Egyptian provinces as a preliminary investigation Open
Chicken anemia virus (CAV) is a widespread and economically significant pathogen in the poultry industry. In this study 110 samples were collected from various poultry farms in selected Egyptian provinces during 2021–2022 and were tested a…
Enantioselective synthesis, characterization, molecular docking simulation and ADMET profiling of α-alkylated carbonyl compounds as antimicrobial agents Open
All living organisms produce only one enantiomer, so we found that all natural compounds are presented in enantiomerically pure form. Asymmetric synthesis is highly spread in medicinal chemistry because enantiomerically pure drugs are high…
Design, Synthesis, Characterization, and Antimicrobial Properties of New Azo Disperse Dyes Incorporating Quinazolinone-Pyrazolone Moieties and Their Applications for Dyeing of Polyester Fabrics Open
The current study outlines a straightforward and efficient method for creating new quinazolinone disperse dyes based on pyrazolone moieties, starting with quinazolinone and a variety of substituted pyrazolone as couplers. The synthesized d…
View article: Individual ingredients of NP-101 (Thymoquinone formula) inhibit SARS-CoV-2 pseudovirus infection
Individual ingredients of NP-101 (Thymoquinone formula) inhibit SARS-CoV-2 pseudovirus infection Open
Thymoquinone TQ, an active ingredient of Nigella Sativa, has been shown to inhibit COVID-19 symptoms in clinical trials. Thymoquinone Formulation (TQF or NP-101) is developed as a novel enteric-coated medication derivative from Nigella Sat…
View article: Emergence of the Novel Infectious bursal disease viruse Variant in Vaccinated Poultry Flocks in Egypt
Emergence of the Novel Infectious bursal disease viruse Variant in Vaccinated Poultry Flocks in Egypt Open
Infectious bursal disease viruses (IBDVs) have a profound impact on poultry production worldwide, directly causing mortality rates of up to 100%, and indirectly through their immunosuppressive effects. Since the emergence of the antigenica…
Hyperspectral reflectance and agro-physiological traits for field identification of salt-tolerant wheat genotypes using the genotype by yield*trait biplot technique Open
Introduction Salinity is the abiotic obstacle that diminishes food production globally. Salinization causes by natural conditions, such as climate change, or human activities, e.g., irrigation and derange misuse. To cope with the salinity …
New class of azo reactive disperse dyes based on quinazolinone moieties: synthesis, characterization, and dyeing performance on blend fabrics with ultraviolet protection Open
This study describes an efficient and simple technique for the synthesis of four new quinazolinone reactive disperse dyes, which include 1,3,5-trichlorotriazine (cyanuric chloride) group from quinazolinone and various substituted primary a…
Evaluation of Wheat Genotypes under Water Regimes Using Hyperspectral Reflectance and Agro-Physiological Parameters via Genotype by Yield*Trait Approaches in Sakha Station, Delta, Egypt Open
Drought is an environmental abiotic stress that diminishes wheat production worldwide. In the present study, we evaluated fifty bread wheat genotypes (arranged in alpha lattice design) under two main water regimes, water-deficit (two surfa…
Chemodiversity and bioactivity assessment of phlorotannins from some Phaeophyta species from the Red Sea Open
Phlorotannins are a unique and diverse category of secondary polyphenolic metabolites biosynthesized by brown seaweeds. They have revealed a huge potential for food and medicinal applications. In this study, five brown seaweed species were…
Effect of different organic materials on some chemical properties of some soils in Delta region Open
The low organic matter content of the cultivated soils in Egypt with weed infestations led to a decrease in crop productivity, so this study aimed to study the effect of the different types of organic amendments and polymeric granstar as p…
Enantioselective synthesis, characterization and biological evaluation of α-alkylated acids Open
all living organisms produce only one enantiomer so we found that all natural compounds are presented in enantiomerically pure form. Asymmetric synthesis is highly spread in pharmaceutical industry because enantiomerically pure drugs are h…
Spectral Reflectance Indices’ Performance to Identify Seawater Salinity Tolerance in Bread Wheat Genotypes Using Genotype by Yield*Trait Biplot Approach Open
Salinity stress harms crop yield and productivity worldwide. This study aimed to identify genotypes with higher grain yield and/or salinity tolerance from forty bread wheat genotypes evaluated under seawater diluted at 4.0, 8.0, or 12.0 dS…
Asymmetric synthesis of α-alkylated carbonyl compounds and their biological application Open
Creation of asymmetric centers is the fundamental basis of asymmetric synthesis as the resulting diastereomers or enantiomers are formed in unequal ratio.This is obtained by the creation of novel asymmetric centers either in a chiral molec…
View article: Emergence of Highly Pathogenic Avian Influenza A Virus (H5N1) of Clade 2.3.4.4b in Egypt, 2021–2022
Emergence of Highly Pathogenic Avian Influenza A Virus (H5N1) of Clade 2.3.4.4b in Egypt, 2021–2022 Open
Wild migratory birds have the capability to spread avian influenza virus (AIV) over long distances as well as transmit the virus to domestic birds. In this study, swab and tissue samples were obtained from 190 migratory birds during close …
Genetic Changes of S Gene during Co-inoculation of Two Infectious Bronchitis Virus Vaccines in SPF Chicks Open
Despite widespread immunizations, infectious bronchitis (IB) remains a significant issue in the Egyptian poultry industry. Multiple IBV genotypes, GI-1, GI-13, GI-16, and GI-23 have been continually circulating among chicken flocks in Egyp…
Asymmetric synthesis of α-alkylated carbonyl compounds and their biological applications Open
Creation of asymmetric centers is the fundamental basis of asymmetric synthesis as the resulting diastereomers or enantiomers are formed in unequal ratio.This is obtained by the creation of novel asymmetric centers either in a chiral molec…
View article: Molecular Epidemiology and Evolutionary Analysis of Avian Influenza A(H5) Viruses Circulating in Egypt, 2019–2021
Molecular Epidemiology and Evolutionary Analysis of Avian Influenza A(H5) Viruses Circulating in Egypt, 2019–2021 Open
The highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in Egypt in late 2016. Since then, the virus has spread rapidly among different poultry sectors, becoming the dominant HPAI H5 subtype reported in Egypt. Different …