Adelbert De Clercq
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View article: Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture
Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture Open
Thoracic aortic aneurysm and dissection (TAAD) associates with a high mortality rate. Despite the existence of different mouse models for TAAD, the underlying disease mechanisms remain elusive. Treatment options are limited and mainly cons…
View article: Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development
Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development Open
SNARE proteins comprise a conserved protein family responsible for catalyzing membrane fusion during vesicle traffic. Syntaxin18 (STX18) is a poorly characterized endoplasmic reticulum (ER)-resident t-SNARE. Recently, together with TANGO1 …
View article: Elevated Water CO2 Can Prevent Dietary-Induced Osteomalacia in Post-Smolt Atlantic Salmon (Salmo salar, L.)
Elevated Water CO2 Can Prevent Dietary-Induced Osteomalacia in Post-Smolt Atlantic Salmon (Salmo salar, L.) Open
Expansion of land-based systems in fish farms elevate the content of metabolic carbon dioxide (CO2) in the water. High CO2 is suggested to increase the bone mineral content in Atlantic salmon (Salmo salar, L.). Conversely, low dietary phos…
View article: A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract
A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract Open
View article: Alterations in glycosaminoglycan biosynthesis associated with the Ehlers-Danlos syndromes
Alterations in glycosaminoglycan biosynthesis associated with the Ehlers-Danlos syndromes Open
Proteoglycans consist of a core protein substituted with one or more glycosaminoglycan (GAG) chains and execute versatile functions during many physiological and pathological processes. The biosynthesis of GAG chains is a complex process t…
View article: What will happen to my smolt at harvest? Individually tagged Atlantic salmon help to understand possible progression and regression of vertebral deformities
What will happen to my smolt at harvest? Individually tagged Atlantic salmon help to understand possible progression and regression of vertebral deformities Open
Vertebral deformities can impair health, welfare, and product quality in farmed Atlantic salmon. Deformities detected early in the production cycle raise questions about their further development: which types of deformities will progress a…
View article: Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes
Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes Open
View article: Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome
Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome Open
View article: An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome
An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome Open
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by pathogenic variants in the gene coding for the extracellular matrix protein fibrillin-1. While the disease affects multiple organ systems, the most life-threatening …
View article: Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome
Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome Open
View article: Author response for "Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR ‐based functional screening of osteoporosis candidate genes"
Author response for "Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR ‐based functional screening of osteoporosis candidate genes" Open
View article: Vertebral column adaptations in juvenile Atlantic salmon Salmo salar, L. as a response to dietary phosphorus
Vertebral column adaptations in juvenile Atlantic salmon Salmo salar, L. as a response to dietary phosphorus Open
View article: Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing (WES) and linkage analysis
Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing (WES) and linkage analysis Open
View article: Identification of skeletal deformities towards deep phenotyping of zebrafish (Danio rerio) connective tissue disease models
Identification of skeletal deformities towards deep phenotyping of zebrafish (Danio rerio) connective tissue disease models Open
View article: Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes
Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes Open
Genomewide association studies (GWAS) have improved our understanding of the genetic architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute functional skeletal contributions of candidate genes to osteoporo…
View article: b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region
b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region Open
Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage r…
View article: Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes
Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes Open
Genomewide association studies (GWAS) have improved our understanding of the genetic architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute functional skeletal contributions of candidate genes to osteoporo…
View article: Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders
Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders Open
Animal models are essential tools for addressing fundamental scientific questions about skeletal diseases and for the development of new therapeutic approaches. Traditionally, mice have been the most common model organism in biomedical res…
View article: <i>b3galt6</i>knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region
<i>b3galt6</i>knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region Open
Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage r…
View article: Supernumerary teeth in the pharyngeal dentition of slow-developing zebrafish (<i>Danio rerio</i>, Hamilton, 1822)
Supernumerary teeth in the pharyngeal dentition of slow-developing zebrafish (<i>Danio rerio</i>, Hamilton, 1822) Open
Heterochrony, which is a change in the developmental rate and timing, is one of the mechanisms proposed to explain alterations in meristic characters, such as the variation in the numbers of skeletal elements between individuals within a p…
View article: The effect of incubation temperature on early malformation, regionalisation and meristic characters of the vertebral column in farmed Chinook salmon (Oncorhynchus tshawytscha) : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Science at Massey University, Manawatū, Palmerston North, New Zealand
The effect of incubation temperature on early malformation, regionalisation and meristic characters of the vertebral column in farmed Chinook salmon (Oncorhynchus tshawytscha) : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Science at Massey University, Manawatū, Palmerston North, New Zealand Open
Chapter 3 was published as: De Clercq, A., Perrott, M.R., Davie, P.S., Preece, M.A., Huysseune, A., & Witten, P.E. (2017). The external phenotype–skeleton link in post‐hatch farmed Chinook salmon (Oncorhynchus tshawytscha). Journal of Fish…
View article: Vertebral column regionalisation in Chinook salmon, <i>Oncorhynchus tshawytscha</i>
Vertebral column regionalisation in Chinook salmon, <i>Oncorhynchus tshawytscha</i> Open
Teleost vertebral centra are often similar in size and shape, but vertebral‐associated elements, i.e. neural arches, haemal arches and ribs, show regional differences. Here we examine how the presence, absence and specific anatomical and h…