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View article: 20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights
20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights Open
Introduction The Montreal Cystic Fibrosis Related Diabetes Screening Cohort (MCFC) was established in 2004 to study the prevalence, risk factors and management of cystic fibrosis-related diabetes, a significant extrapulmonary complication …
View article: The effect of a pre-meal snack and/or postprandial exercise on breakfast glycemic excursion in adults with cystic fibrosis: A pilot study
The effect of a pre-meal snack and/or postprandial exercise on breakfast glycemic excursion in adults with cystic fibrosis: A pilot study Open
Repeated short bouts of post-meal physical activity may positively impact PPG control in adults with CF, with or without the addition of a pre-meal soy snack. A pre-meal snack alone does not improve PPG.
View article: Cystic fibrosis‐related diabetes develops from a combination of insulin secretion defects and insulin resistance
Cystic fibrosis‐related diabetes develops from a combination of insulin secretion defects and insulin resistance Open
Aim The relative contributions of insulin secretory defects and possible additional contribution of insulin resistance for the development of cystic fibrosis (CF)‐related diabetes (CFRD) are poorly understood. We aimed to (a) determine whi…
View article: Impact of a high emergency lung transplantation programme for cystic fibrosis in France: insight from a comparison with Canada
Impact of a high emergency lung transplantation programme for cystic fibrosis in France: insight from a comparison with Canada Open
Background France implemented a high emergency lung transplantation (HELT) programme nationally in 2007. A similar programme does not exist in Canada. The objectives of our study were to compare health outcomes within France as well as bet…
View article: Validation of short- and long-term demographic forecasts using the Canadian Cystic Fibrosis Registry
Validation of short- and long-term demographic forecasts using the Canadian Cystic Fibrosis Registry Open
National cystic fibrosis (CF) data registries track patient characteristics over time and have provided insight into both emerging trends and current clinical needs. In a recent study, Burgel et al . [1] utilised the flow method, a demogra…
View article: Hepatic enzyme ALT as a marker of glucose abnormality in men with cystic fibrosis
Hepatic enzyme ALT as a marker of glucose abnormality in men with cystic fibrosis Open
Adult CF men with higher ALT show an increased frequency of dysglycemia and de novo CFRD, lower insulin sensitivity and higher eight. Our data suggests that ALT levels could be an interesting tool to guide targeted diabetes screening, part…
View article: Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon? Open
Background . The prevalence of adrenal insufficiency (AI) in cystic fibrosis (CF) is unknown. The frequent use of glucocorticoids (inhaled or systemic) may induce the long-term suppression of the hypothalamic-pituitary-adrenal axis. Method…
View article: Stability of Commercially Available Glucagon Formulation for Dual-Hormone Artificial Pancreas Clinical Use
Stability of Commercially Available Glucagon Formulation for Dual-Hormone Artificial Pancreas Clinical Use Open
Available glucagon formulations are chemically and physically stable, as well as compatible with delivery through subcutaneous infusion pumps over 24 h and can be used in long-term clinical trials.
View article: Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis
Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis Open
Purpose Cystic Fibrosis (CF) is the most common genetic disorder and, with improved survival, glucose abnormalities have emerged as a major comorbidity. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a regulator of plasma LDL-chole…