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View article: Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone
Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone Open
The germinal center (GC) dark zone (DZ) and light zone represent distinct anatomical regions in lymphoid tissue where B cell proliferation, immunoglobulin diversification, and selection are coordinated. Diffuse large B cell lymphomas (DLBC…
View article: Analysis of Single Nuclei in a Microfluidic Cytometer Towards Metaphase Enrichment
Analysis of Single Nuclei in a Microfluidic Cytometer Towards Metaphase Enrichment Open
Identifying analyzable metaphase chromosomes is crucial for karyotyping, a common procedure used by clinicians to diagnose genetic disorders and some forms of cancer. This task is often laborious and time‐consuming, making it essential to …
View article: Immunogenic Cell Death Inducers in Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors
Immunogenic Cell Death Inducers in Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors Open
The combination of chemotherapeutic agents with immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment. However, its success is often limited by insufficient immune priming in certain tumors, including pediatric malignanci…
View article: Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B Open
Correction to: Nature Immunologyhttps://doi.org/10.1038/s41590-022-01290-3, published online 24 August 2022. In the version of this article initially published, due to an error during figure assembly, the image shown in the top-right WT mi…
View article: Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells
Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells Open
Epigenetic deregulation is implied in cancer initiation and resistance to antitumor drugs. In melanoma, aberrant DNA hypermethylation is frequently observed, resulting in the silencing of several genes involved in cell cycle regulation, ap…
View article: Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma
Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma Open
The germinal center (GC) dark zone (DZ) and light zone (LZ) regions spatially separate expansion and diversification from selection of antigen-specific B-cells to ensure antibody affinity maturation and B cell memory. The DZ and LZ differ …
View article: Numerical and experimental characterization of a piezoelectric actuator for microfluidic cell sorting
Numerical and experimental characterization of a piezoelectric actuator for microfluidic cell sorting Open
Piezoelectric actuators offer great opportunities for precise and low-cost control of fluids at the microscale. Microfluidic systems with integrated piezoelectric actuators find application as droplet generators, micropumps, and microsorte…
View article: On the compatibility of single-cell microcarriers (nanovials) with microfluidic impedance cytometry
On the compatibility of single-cell microcarriers (nanovials) with microfluidic impedance cytometry Open
We investigate for the first time the compatibility of nanovials with microfluidic impedance cytometry, paving the way for the successful combination of these single-cell technologies.
View article: Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles
Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles Open
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
View article: Rapid Assessment of Susceptibility of Bacteria and Erythrocytes to Antimicrobial Peptides by Single-Cell Impedance Cytometry
Rapid Assessment of Susceptibility of Bacteria and Erythrocytes to Antimicrobial Peptides by Single-Cell Impedance Cytometry Open
Antimicrobial peptides (AMPs) represent a promising class of compounds to fight antibiotic-resistant infections. In most cases, they kill bacteria by making their membrane permeable and therefore exhibit low propensity to induce bacterial …
View article: Rapid assessment of susceptibility of bacteria and erythrocytes to antimicrobial peptides by single-cell impedance cytometry
Rapid assessment of susceptibility of bacteria and erythrocytes to antimicrobial peptides by single-cell impedance cytometry Open
Antimicrobial peptides (AMPs) represent a promising class of compounds to fight antibiotic-resistant infections. In most cases, they kill bacteria by making their membrane permeable and therefore exhibit low propensity to induce bacterial …
View article: Deciphering impedance cytometry signals with neural networks
Deciphering impedance cytometry signals with neural networks Open
A successful outcome of the coupling between microfluidics and AI: neural networks tackle the signal processing challenges of single-cell microfluidic impedance cytometry.
View article: Estimation Algorithm for a Hybrid PDE–ODE Model Inspired by Immunocompetent Cancer-on-Chip Experiment
Estimation Algorithm for a Hybrid PDE–ODE Model Inspired by Immunocompetent Cancer-on-Chip Experiment Open
The present work is motivated by the development of a mathematical model mimicking the mechanisms observed in lab-on-chip experiments, made to reproduce on microfluidic chips the in vivo reality. Here we consider the Cancer-on-Chip experim…
View article: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B Open
Cancer stem cells (CSCs) are immature, immortal cells within tumors, adept at resisting therapeutic pressure and responsible for local and distant disease recurrence. Non-genetic mechanisms of acquired resistance are increasingly being des…
View article: Oncoimmunology Meets Organs-on-Chip
Oncoimmunology Meets Organs-on-Chip Open
Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy. Infiltration of immune cells within …
View article: Optical detection of Aflatoxins B in grained almonds using fluorescence spectroscopy and machine learning algorithms
Optical detection of Aflatoxins B in grained almonds using fluorescence spectroscopy and machine learning algorithms Open
Aflatoxins are fungal metabolites extensively produced by many different fungal species that may contaminate a wide range of agricultural food products. They have been studied extensively because of being associated with various chronic an…
View article: Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca<sup>2+</sup> signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea
Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca<sup>2+</sup> signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea Open
Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca2+ wave propagation in the greater epit…
View article: IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing
IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing Open
Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the ‘alarmin…
View article: Oil-in-Water fL Droplets by Interfacial Spontaneous Fragmentation and Their Electrical Characterization
Oil-in-Water fL Droplets by Interfacial Spontaneous Fragmentation and Their Electrical Characterization Open
Inkjet printing is here employed for the first time as a method to produce femtoliter-scale oil droplets dispersed in water. In particular, picoliter-scale fluorinated oil (FC40) droplets are printed in the presence of perfluoro-1-octanol …
View article: High-throughput electrical position detection of single flowing particles/cells with non-spherical shape
High-throughput electrical position detection of single flowing particles/cells with non-spherical shape Open
A novel all-electrical approach for cross-sectional position detection of flowing particles and cells.