Adele Faulkner
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View article: Discovery of Novel UDP- <i>N</i> -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against <i>Pseudomonas aeruginosa</i>
Discovery of Novel UDP- <i>N</i> -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against <i>Pseudomonas aeruginosa</i> Open
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pse…
View article: Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles
Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles Open
The scope and mechanism of aza-Heck methodologies that provide chiral heterocyclic systems are outlined.
View article: Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters
Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters Open
A SPINOL-derived P,N-ligand system enables Pd-catalyzed 5-exo cyclization of oxime esters with trisubstituted alkenes to generate dihydropyrroles in up to 86% yield and 95 : 5 e.r.
View article: Allosteric Regulation of the Rotational Speed in a Light-Driven Molecular Motor
Allosteric Regulation of the Rotational Speed in a Light-Driven Molecular Motor Open
The rotational speed of an overcrowded alkene-based molecular rotary motor, having an integrated 4,5-diazafluorenyl coordination motif, can be regulated allosterically via the binding of metal ions. DFT calculations have been used to predi…
View article: CCDC 1438659: Experimental Crystal Structure Determination
CCDC 1438659: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1438660: Experimental Crystal Structure Determination
CCDC 1438660: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …