Adele Gabba
YOU?
Author Swipe
View article: Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity
Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity Open
Cancer vaccine development is inhibited by a lack of strategies for directing dendritic cell (DC) induction of effective tumor-specific cellular immunity. Pathogen engagement of DC lectins and toll-like receptors (TLRs) is thought to shape…
View article: Glycan-costumed virus-like particles promote type 1 anti-tumor immunity
Glycan-costumed virus-like particles promote type 1 anti-tumor immunity Open
Cancer vaccine development is inhibited by a lack of strategies for directing dendritic cell (DC) induction of effective tumor-specific cellular immunity. Pathogen engagement of DC lectins and toll-like receptors (TLRs) shapes immunity by …
View article: Beyond the Crystal Structure of Human Macrophage C-Type Lectin
Beyond the Crystal Structure of Human Macrophage C-Type Lectin Open
ADVERTISEMENT RETURN TO ARTICLES ASAPViewpointNEXTBeyond the Crystal Structure of Human Macrophage C-Type LectinAdele Gabba*Adele GabbaDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United S…
View article: MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response
MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response Open
Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans (e.g., Tn antigen). Dendritic…
View article: The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response
The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response Open
Tumor‐associated carbohydrate antigens are overexpressed as altered‐self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been develo…
View article: Imitating evolution’s tinkering by protein engineering reveals extension of human galectin-7 activity
Imitating evolution’s tinkering by protein engineering reveals extension of human galectin-7 activity Open
Wild-type lectins have distinct types of modular design. As a step to explain the physiological importance of their special status, hypothesis-driven protein engineering is used to generate variants. Concerning adhesion/growth-regulatory g…
View article: Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen Open
The human macrophage galactose lectin (MGL) is an endocytic type II transmembrane receptor expressed on immature monocyte-derived dendritic cells and activated macrophages and plays a role in modulating the immune system in response to inf…
View article: Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives Open
Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and evaluation of multivalen…
View article: How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1
How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1 Open
Discoveries on involvement of glycan–protein recognition in many (patho)physiological processes are directing attention to exploring the significance of a fundamental structural aspect of sugar receptors beyond glycan specificity, i.e., oc…
View article: Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform Open
Introducing tissue sections for testing glycocluster activity as inhibitors of lectin binding close toin vivoconditions.
View article: Synthesis and Biological Evaluation of Migrastatin Macrotriazoles
Synthesis and Biological Evaluation of Migrastatin Macrotriazoles Open
The synthesis of three macrotriazoles that are analogues of migrastatin is reported. The synthesis is based on copper(I)‐ and ruthenium‐catalyzed azide–alkyne cycloaddition reactions. The enantiopure terminal alkyne derivatives were prepar…