Adele L. Boskey
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View article: Changes in matrix phosphorylation during bovine dentin development
Changes in matrix phosphorylation during bovine dentin development Open
Phosphorylation of the organic matrix proteins of dentin is important for the initiation of mineralization, but its relevance in later mineralization stages is controversial. The objective of this study was to analyze changes in the total …
View article: Reduced Tissue-Level Stiffness and Mineralization in Osteoporotic Cancellous Bone
Reduced Tissue-Level Stiffness and Mineralization in Osteoporotic Cancellous Bone Open
Osteoporosis alters bone mass and composition ultimately increasing the fragility of primarily cancellous skeletal sites; however, effects of osteoporosis on tissue-level mechanical properties of cancellous bone are unknown. Dual-energy x-…
View article: Decorin modulates collagen matrix assembly and mineralization
Decorin modulates collagen matrix assembly and mineralization Open
Decorin (DCN) is one of the major matrix proteoglycans in bone. To investigate the role of DCN in matrix mineralization, the expression of DCN in MC3T3-E1 (MC) cell cultures and the phenotypes of MC-derived clones expressing higher (sense;…
View article: Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth
Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth Open
Mice lacking HIP/RPL29, a component of the ribosomal machinery, display increased bone fragility. To understand the effect of sub-efficient protein synthetic rates on mineralized tissue quality, we performed dynamic and static histomorphom…
View article: Issue Information ‐ Editorial Board and TOC
Issue Information ‐ Editorial Board and TOC Open
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View article: Skin Ultrasound Measurement as a Potential Marker of Bone Quality: A Prospective Pilot Study of Patients undergoing Lumbar Spinal Fusion
Skin Ultrasound Measurement as a Potential Marker of Bone Quality: A Prospective Pilot Study of Patients undergoing Lumbar Spinal Fusion Open
Bone mineral density (BMD) is not the sole predictor of fracture development. Qualitative markers including bone collagen maturity contribute to bone fragility. Bone and related type I collagen containing connective tissues degenerate in p…
View article: A Multicenter Observational Cohort Study to Evaluate the Effects of Bisphosphonate Exposure on Bone Mineral Density and Other Health Outcomes in Osteogenesis Imperfecta
A Multicenter Observational Cohort Study to Evaluate the Effects of Bisphosphonate Exposure on Bone Mineral Density and Other Health Outcomes in Osteogenesis Imperfecta Open
Osteogenesis imperfecta (OI) is characterized by low bone mass and bone fragility. Using data from a large cohort of individuals with OI from the Osteogenesis Imperfecta Foundation's linked clinical research centers, we examined the associ…
View article: Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy
Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy Open
Bone is a highly organized tissue in which each structural level influences the macroscopic and microscopic mechanical behavior. In particular, the quantity, quality, and distribution of the different bone components, i.e. collagen matrix …
View article: Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women
Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women Open
Women with equivalent areal bone mineral densities may show a different fracture incidence due to differences in bone intrinsic quality. Previously, Fourier transform infrared spectroscopic imaging (FTIRI) on the same iliac bone biopsies r…
View article: Biomolecular regulation, composition and nanoarchitecture of bone mineral
Biomolecular regulation, composition and nanoarchitecture of bone mineral Open
Tough natural nanocomposites like bone, nacre and sea sponges contain within their hierarchy, a mineral (phosphate, silicate or carbonate) phase that interacts with an organic phase. In bone, the role of mineral ultrastructure (organizatio…
View article: Bone quality changes associated with aging and disease: a review
Bone quality changes associated with aging and disease: a review Open
Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, …
View article: Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy
Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy Open
The severe sole effects of seizures on the cortical part of bone were reported in our previous study. However, the side effects of anti-epileptic drug therapy on bones has not been differentiated from the effects of the convulsive seizures…
View article: Osteoblast migration in vertebrate bone
Osteoblast migration in vertebrate bone Open
Bone formation, for example during bone remodelling or fracture repair, requires mature osteoblasts to deposit bone with remarkable spatial precision. As osteoblast precursors derive either from circulation or resident stem cell pools, the…
View article: Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion
Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion Open
The anterior cruciate ligament (ACL)‐to‐bone interface constitutes a complex, multi‐tissue structure comprised of contiguous ligament, non‐mineralized fibrocartilage, mineralized fibrocartilage, and bone regions. This composite structure e…
View article: The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data
The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data Open
We would like to comment on the article by Shi and colleagues1 published in this journal. The authors of this article used the growing oim/oim mouse, which we have used to study the effects of potential therapies on osteogenesis imperfecta…
View article: Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease
Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease Open
Growth delay is common in children with chronic kidney disease (CKD), often associated with poor quality of life. The role of anemia in uremic growth delay is poorly understood. Here we describe an induction of uremic growth retardation by…