Adèle L. Marston
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View article: Specialisation of meiotic kinetochores revealed through a synthetic SAC strategy
Specialisation of meiotic kinetochores revealed through a synthetic SAC strategy Open
Meiosis creates haploid gametes through two sequential M phases. While many studies have focused on meiosis I, the molecular events which drive and define meiosis II are largely unknown. Here, we report a novel cell synchronization strateg…
View article: Multi-nucleation in two-cell human embryos stems from spindle and metaphase plate incoherence in the first mitosis
Multi-nucleation in two-cell human embryos stems from spindle and metaphase plate incoherence in the first mitosis Open
The first embryonic division in humans is highly error-prone and a source of aneuploidies. Multi-nucleation is prevalent in two-cell human embryos, with unknown cause. Here, we live-image human zygotes to elucidate the features of the firs…
View article: Attenuation of mosaic aneuploidy and erroneous first mitotic division of human embryos
Attenuation of mosaic aneuploidy and erroneous first mitotic division of human embryos Open
Human reproduction is inherently inefficient 1 and 1 in 6 people worldwide suffer infertility. In vitro fertilisation (IVF) can help some couples conceive, but only ~30% of cycles are successful. One factor affecting IVF efficacy is mitoti…
View article: The functional organisation of the centromere and kinetochore during meiosis
The functional organisation of the centromere and kinetochore during meiosis Open
Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central ro…
View article: Molecular mechanism targeting condensin for chromosome condensation
Molecular mechanism targeting condensin for chromosome condensation Open
Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC activity is specifi…
View article: Distinct roles of spindle checkpoint proteins in meiosis
Distinct roles of spindle checkpoint proteins in meiosis Open
Gametes are produced via meiosis, a specialized cell division associated with frequent errors that cause birth defects and infertility. Uniquely in meiosis I, homologous chromosomes segregate to opposite poles, usually requiring their link…
View article: Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes
Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes Open
Cohesin is a DNA tethering complex essential for chromosome structure and function. In fission yeast, defects in the cohesin loader Mis4 result in chromosome segregation defects and dysregulated expression of genes near chromosome ends. A …
View article: Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes
Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes Open
In brief Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segregation, we propose he…
View article: Molecular basis for condensin enrichment at pericentromeres
Molecular basis for condensin enrichment at pericentromeres Open
Summary Faithful chromosome segregation requires packaging of the genome on both global and local scales. Condensin plays a crucial role at pericentromeres to resist spindle forces and ensure the bioriented attachment of kinetochores to mi…
View article: Checkpoint-independent association of Mad3<sup>BUBR1</sup>with Stu1<sup>CLASP</sup>directs homolog alignment in meiosis I
Checkpoint-independent association of Mad3<sup>BUBR1</sup>with Stu1<sup>CLASP</sup>directs homolog alignment in meiosis I Open
Summary Gametes are produced via meiosis, a specialized cell division associated with frequent errors which cause birth defects and infertility. Uniquely in meiosis I, homologous chromosomes segregate to opposite poles, usually requiring t…
View article: Editor's evaluation: A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination
Editor's evaluation: A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Small R…
View article: Age-dependent loss of cohesion protection in human oocytes
Age-dependent loss of cohesion protection in human oocytes Open
Aneuploid human eggs (oocytes) are a major cause of infertility, miscarriage, and chromosomal disorders. Such aneuploidies increase greatly as women age, with defective linkages between sister chromatids (cohesion) in meiosis as a common c…
View article: eLife assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes
eLife assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Peer review Author response Article and author information Metrics Abstract Cohesin is a trimeric comple…
View article: eLife Assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes
eLife Assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes Open
Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During interphase, it organizes chromosomal DNA topology by extruding loo…
View article: Reviewer #3 (Public Review): Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
Reviewer #3 (Public Review): Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase Open
The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive. Here we show that fission yeast condensin accumula…
View article: eLife assessment: Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
eLife assessment: Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase Open
The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive. Here we show that fission yeast condensin accumula…
View article: A supernumerary synthetic chromosome in<i>Komagataella phaffii</i>as a repository for extraneous genetic material
A supernumerary synthetic chromosome in<i>Komagataella phaffii</i>as a repository for extraneous genetic material Open
Background Komagataella phaffii (Pichia pastoris ) is a methylotropic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins effi…
View article: eLife assessment: Broad functional profiling of fission yeast proteins using phenomics and machine learning
eLife assessment: Broad functional profiling of fission yeast proteins using phenomics and machine learning Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results and discussion Methods Data availability References Peer review Author response Article and author information Abstract Many proteins remain poorly char…
View article: Rewiring of the phosphoproteome executes two meiotic divisions
Rewiring of the phosphoproteome executes two meiotic divisions Open
The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate gametes via meiosis, two distinct and sequential chromosome segregation events occur without an intervening S phase. How canonical cell cycle contro…
View article: eLife Assessment: Broad functional profiling of fission yeast proteins using phenomics and machine learning
eLife Assessment: Broad functional profiling of fission yeast proteins using phenomics and machine learning Open
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe for broad cues on protein functions. We ass…
View article: Reviewer #2 (Public Review): What AlphaFold tells us about cohesin’s retention on and release from chromosomes
Reviewer #2 (Public Review): What AlphaFold tells us about cohesin’s retention on and release from chromosomes Open
Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During interphase, it organizes chromosomal DNA topology by extruding loo…
View article: eLife assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes
eLife assessment: What AlphaFold tells us about cohesin’s retention on and release from chromosomes Open
Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During interphase, it organizes chromosomal DNA topology by extruding loo…
View article: Reviewer #3 (Public Review): Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
Reviewer #3 (Public Review): Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase Open
The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive. Here we show that fission yeast condensin accumula…