Adele M. Doyle
YOU?
Author Swipe
View article: Human fingertip regeneration follows clinical phases with distinct proteomic signatures
Human fingertip regeneration follows clinical phases with distinct proteomic signatures Open
Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap, comprising a puncturable reservoir, wa…
View article: Human fingertip regeneration follows clinical phases with distinct proteomic signatures – a Comprehensive MS/MS analysis
Human fingertip regeneration follows clinical phases with distinct proteomic signatures – a Comprehensive MS/MS analysis Open
Summary Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap, comprising a puncturable reser…
View article: Molecular Circuit Discovery for Mechanobiology of Cardiovascular Disease
Molecular Circuit Discovery for Mechanobiology of Cardiovascular Disease Open
Purpose Cardiovascular diseases, the world’s leading cause of death, are linked to changes in tissue mechanical and material properties that affect the signaling of cells in the damaged tissue. It is hard to predict the effect of altered p…
View article: Investigating Cellular Response to Impact With a Microfluidic MEMS Device
Investigating Cellular Response to Impact With a Microfluidic MEMS Device Open
Although high strain and strain-rate impacts to the human body have been the subject of substantial research at both the systemic and tissue levels, little is known about the celllevel ramifications of such assaults. This is largely due to…
View article: Orchestrating cells on a chip: Employing surface acoustic waves towards the formation of neural networks
Orchestrating cells on a chip: Employing surface acoustic waves towards the formation of neural networks Open
For the investigation of cell-cell interaction in general and for neural communication and future applications of neural networks, a controllable and well-defined network structure is crucial. We here propose the implementation of an acous…
View article: THE μHAMMER: INVESTIGATING CELLULAR RESPONSE TO IMPACT WITH A HIGH THROUGHPUT MICROFLUIDIC MEMS DEVICE
THE μHAMMER: INVESTIGATING CELLULAR RESPONSE TO IMPACT WITH A HIGH THROUGHPUT MICROFLUIDIC MEMS DEVICE Open
We report the application of stress to biological cells at unprecedented strain (50%), strain rate (180,000 s -1 ), and throughput (1,800 cells/min) using a high-speed, high actuation force magnetically-driven MEMS chip.This device is uniq…
View article: Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states Open
The complexity of gene regulatory networks that lead multipotent cells to acquire different cell fates makes a quantitative understanding of differentiation challenging. Using a statistical framework to analyze single-cell transcriptomics …