Adele Moatti
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View article: Round window membrane extracellular vesicles facilitate inner ear drug delivery
Round window membrane extracellular vesicles facilitate inner ear drug delivery Open
Hearing loss affects over 430 million people worldwide, yet effective treatments remain limited, in part due to challenges of inner ear drug delivery, a process that is risky, unreliable, and inefficient. Addressing this challenge calls fo…
View article: Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae
Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae Open
Tissue clearing and light-sheet fluorescence microscopy were applied for 3D profiling of intact cochleae. However, the spiral ganglion neurons (SGNs) remain relatively understudied compared to hair cells and supporting cells, especially in…
View article: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy.
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy. Open
Light-sheet fluorescence microscopy (LSFM) is a minimally invasive and high throughput imaging technique ideal for capturing large volumes of tissue with sub-cellular resolution. A fundamental requirement for LSFM is a seamless overlap of …
View article: Erratum: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publisher's note.
Erratum: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publisher's note. Open
[This corrects the article on p. 5214 in vol. 12, PMID: 34513252.].
View article: A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research
A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research Open
Recent advancements in genome editing techniques, notably CRISPR-Cas9 and TALENs, have marked a transformative era in biomedical research, significantly enhancing our understanding of disease mechanisms and helping develop novel therapies.…
View article: Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs
Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs Open
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear. Although small animal models offer so…
View article: Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models
Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models Open
The inner ear of humans and large animals is embedded in a thick and dense bone that makes dissection challenging. Here, we present a protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal mode…
View article: Novel porcine model reveals two distinct LGR5 cell types during lung development and homeostasis
Novel porcine model reveals two distinct LGR5 cell types during lung development and homeostasis Open
Cells expressing LGR5 play a pivotal role in homeostasis, repair, and regeneration in multiple organs including skin and gastrointestinal tract, yet little is known about their role in the lung. Findings from mice, a widely used animal mod…
View article: Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging
Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging Open
Over 11% of the world's population experience hearing loss. Although there are promising studies to restore hearing in rodent models, the size, ontogeny, genetics, and frequency range of hearing of most rodents' cochlea do not match that o…
View article: Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation Open
Serious bone injuries have devastating effects on the lives of patients including limiting working ability and high cost. Orthopedic implants can aid in healing injuries to an extent that exceeds the natural regenerative capabilities of bo…
View article: Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy Open
Light-sheet fluorescence microscopy (LSFM) is a minimally invasive and high throughput imaging technique ideal for capturing large volumes of tissue with sub-cellular resolution. A fundamental requirement for LSFM is a seamless overlap of …
View article: Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy
Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy Open
Hearing loss is a prevalent disorder that affects people of all ages. On top of the existing hearing aids and cochlear implants, there is a growing effort to regenerate functional tissues and restore hearing. However, studying and evaluati…
View article: Supplementary document for Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy - 4858679.pdf
Supplementary document for Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy - 4858679.pdf Open
Supplementary Material
View article: Mechanism of strain relaxation: key to control of structural and electronic transitions in VO<sub>2</sub> thin-films
Mechanism of strain relaxation: key to control of structural and electronic transitions in VO<sub>2</sub> thin-films Open
VO2 is a smart transition-metal oxide, which exhibits a tetragonal-to-monoclinic phase transition at ∼ 68°C. We report a case where both tetragonal and monoclinic phases exist in relaxed and strained domains, respectively, above the transi…