Adele Murrell
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View article: Cell identity and 5-hydroxymethylcytosine
Cell identity and 5-hydroxymethylcytosine Open
Epigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce chang…
View article: Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation
Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation Open
Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we ex…
View article: Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing
Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing Open
5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are modified versions of cytosine in DNA with roles in regulating gene expression. Using whole genomic DNA from mouse cerebellum, we have benchmarked 5mC and 5hmC detection by Oxfor…
View article: Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters Open
Background There is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However, these studies frequently do not consider parent-of-origin differences, such as genomic imprin…
View article: 5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation
5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation Open
Cytosine hydroxymethylation (5hmC) in mammalian DNA is the product of oxidation of methylated cytosines (5mC) by Ten-Eleven-Translocation (TET) enzymes. While it has been shown that the TETs influence 5mC metabolism, pluripotency and diffe…
View article: Being in a loop: how long non-coding RNAs organise genome architecture
Being in a loop: how long non-coding RNAs organise genome architecture Open
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat. Genet. (2002…
View article: <i>HNF1B</i> variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
<i>HNF1B</i> variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer Open
Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 wit…