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View article: 482 Deciphering the heterogeneity of B-cell checkpoint inhibitors within tertiary lymphoid structures: Implications for lung cancer immunotherapy
482 Deciphering the heterogeneity of B-cell checkpoint inhibitors within tertiary lymphoid structures: Implications for lung cancer immunotherapy Open
Background Tertiary lymphoid structures (TLS) are ectopic lymphoid formations and sites of local immune response, where B-cells, among other immune cells, play critical roles.1 2 In the tumor microenvironment TLS play pivotal roles in the …
View article: 990 Heterogeneity in glioblastoma tumor microenvironment: strategies for cancer-associated fibroblast targeting
990 Heterogeneity in glioblastoma tumor microenvironment: strategies for cancer-associated fibroblast targeting Open
Background Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by a poorly accessible microenvironment that render it notoriously hard to treat. The insufficient treatment success is, in large parts, due…
View article: 527 Spatial proteomic and transcriptomic biomarkers of response to immune checkpoint inhibitors in operable lung cancer
527 Spatial proteomic and transcriptomic biomarkers of response to immune checkpoint inhibitors in operable lung cancer Open
Background Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. There is a strong rationale for incorporating immunotherapy into the treatment of early-stage NSCLC, given the breakthrough results with PD-1 checkpo…