Andrea Romano
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View article: Pregnancy with vitrified oocytes after fertility sparing surgery in a patient with fallopian tube cancer and a BRCA2 mutation: A case report and literature review
Pregnancy with vitrified oocytes after fertility sparing surgery in a patient with fallopian tube cancer and a BRCA2 mutation: A case report and literature review Open
High-grade carcinomas affecting the ovary or peritoneum may originate from the epithelium of the fallopian tubes. Whilst gynecological cancers are more frequent in post-menopausal patients, 12.1% of ovarian malignancies are diagnosed in pa…
View article: The Expanding Frontier: The Role of Artificial Intelligence in Pediatric Neuroradiology
The Expanding Frontier: The Role of Artificial Intelligence in Pediatric Neuroradiology Open
Artificial intelligence (AI) is revolutionarily shaping the entire landscape of medicine and particularly the privileged field of radiology, since it produces a significant amount of data, namely, images. Currently, AI implementation in ra…
View article: P-422 Endometrial 17β-estradiol production by local steroid-metabolizing enzymes in IVF patients with recurrent implantation failure (RIF) versus control subjects
P-422 Endometrial 17β-estradiol production by local steroid-metabolizing enzymes in IVF patients with recurrent implantation failure (RIF) versus control subjects Open
Study question Is the endometrial synthesis and inactivation of 17β-estradiol by steroid-metabolizing enzymes altered between IVF patients with recurrent implantation failure (RIF) and control subjects? Summary answer Synthesis and inactiv…
View article: Endometrial metabolism of 17β-estradiol during the window of implantation in women with recurrent implantation failure
Endometrial metabolism of 17β-estradiol during the window of implantation in women with recurrent implantation failure Open
Objectives Alterations in 17β-estradiol metabolism are known to potentially impair endometrial receptivity. Previous pioneering studies have investigated the role of endometrial steroid metabolism by determining steroid hormone levels and …
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research Open
The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, ha…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models Open
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models Open
In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but a lack of harmonization impedes reproducibility and comparability of results among investigato…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis Open
Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ov…
View article: Pilot Data Suggest That Obesity and Presence of Malignancy Are Associated with Altered Immune Cell Infiltration in Endometrial Biopsies
Pilot Data Suggest That Obesity and Presence of Malignancy Are Associated with Altered Immune Cell Infiltration in Endometrial Biopsies Open
(1) Background: The worldwide endometrial cancer (EC) incidence is rising, amongst others linked to obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome, possibly due to low-grade adipose tissue inflammation. We studied immune …
View article: Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research
Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research Open
Murine xenograft models are valuable and increasingly used preclinical tools in cancer research to understand disease pathogenesis and guide treatment options. The aim of this narrative review is to summarize the studies that employed mous…
View article: Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research
Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research Open
Murine xenograft models are valuable and increasingly used preclinical tools in cancer research to understand disease pathogenesis and guide treatment options. The aim of this narrative review is to summarize the studies that employed mous…
View article: Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)—a prospective cohort follow-up study
Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)—a prospective cohort follow-up study Open
Purpose The goal of this study was to determine ongoing pregnancy rate, time to pregnancy and embryo transfers to pregnancy within a cohort of patients with recurrent implantation failure (RIF). Methods IVF patients with RIF were included …
View article: Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma
Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma Open
Background: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases…
View article: The endometrial transcriptome of infertile women with and without implantation failure
The endometrial transcriptome of infertile women with and without implantation failure Open
Introduction Implantation failure after transferring morphologically “good‐quality” embryos in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) may be explained by impaired endometrial receptivity. Analyzing the endometri…
View article: Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper
Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper Open
Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represe…
View article: PARP-1, EpCAM, and FRα as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis
PARP-1, EpCAM, and FRα as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis Open
Endometriosis is a gynecological disease characterized by the presence of endometrial tissue in abnormal locations, leading to severe symptoms, inflammation, pain, organ dysfunction, and infertility. Surgical removal of endometriosis lesio…
View article: Editorial: Translational research for better diagnosis and treatment of endometrial cancer
Editorial: Translational research for better diagnosis and treatment of endometrial cancer Open
EDITORIAL article Front. Oncol., 19 October 2023Sec. Gynecological Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1305140
View article: Author reply
Author reply Open
Contains fulltext : 305144.pdf (Publisher’s version ) (Open Access)
View article: Redefining the Position of Hormonal Therapy in Endometrial Cancer in the Era of Molecular Classification
Redefining the Position of Hormonal Therapy in Endometrial Cancer in the Era of Molecular Classification Open
Contains fulltext : 301042.pdf (Publisher’s version ) (Open Access)
View article: Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study
Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study Open
Graphical abstract Abstract Sex steroids are converted to bioactive metabolites and vice versa by endometrial steroid-metabolising enzymes. Studies indicate that alterations in this metabolism might affect endometrial receptivity. This pil…
View article: #383 BioEndoCar: identifying candidate biomarkers for diagnosis and prognosis of endometrial carcinoma using machine learning and artificial intelligence
#383 BioEndoCar: identifying candidate biomarkers for diagnosis and prognosis of endometrial carcinoma using machine learning and artificial intelligence Open
Introduction/Background Endometrial carcinoma (EC) is the most common gynaecological malignancy in the developed world. Currently, no valid non-invasive diagnostic or prognostic methods exist, making diagnosis and treatment rely on histopa…
View article: “I’m looking through you”: What consumers and manufacturers need to know about non-invasive diagnostic tests for endometriosis
“I’m looking through you”: What consumers and manufacturers need to know about non-invasive diagnostic tests for endometriosis Open
Consequences of the shift from the use of non-invasive testing for diagnosis to screening purposes • As the high-throughput screening and sequencing become increasingly faster and affordable, that there will be a swell of commercial non-in…
View article: P-479 Prognosis for ongoing pregnancy after recurrent implantation failure (RIF) following IVF/ICSI treatment
P-479 Prognosis for ongoing pregnancy after recurrent implantation failure (RIF) following IVF/ICSI treatment Open
Study question What is the cumulative ongoing pregnancy rate within one year after visiting the RIF outpatient clinic in patients with RIF after IVF/ICSI treatment? Summary answer The cumulative ongoing pregnancy rate was 42.9% with a mean…
View article: The impact of adipose tissue distribution on endometrial cancer: a systematic review
The impact of adipose tissue distribution on endometrial cancer: a systematic review Open
Introduction Endometrial cancer (EC) is the most common gynecological cancer with a rising incidence, attributed to advanced life expectancy and obesity. Adipose tissue (AT) is an important endocrine organ, and its metabolic activity is af…
View article: Targeting the formation of estrogens for treatment of hormone dependent diseases–current status
Targeting the formation of estrogens for treatment of hormone dependent diseases–current status Open
Local formation and action of estrogens have crucial roles in hormone dependent cancers and benign diseases like endometriosis. Drugs that are currently used for the treatment of these diseases act at the receptor and at the pre-receptor l…