Adelina Amorim
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View article: Pessary for Prevention of Preterm Birth and Perinatal Mortality in Pregnancies with a Short Cervix: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Pessary for Prevention of Preterm Birth and Perinatal Mortality in Pregnancies with a Short Cervix: Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of cervical pessaries in preventing perinatal mortality and extreme preterm birth in pregnancies characterized by a short cervix. Methods: The analysis incl…
View article: Use of inhaled corticosteroids in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Use of inhaled corticosteroids in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC) Open
Introduction Current bronchiectasis guidelines advise against the use of inhaled corticosteroids (ICS) except in patients with associated asthma, allergic bronchopulmonary aspergillosis (ABPA) and/or chronic obstructive pulmonary disease (…
View article: Placebo and Nocebo Responses in Multiple System Atrophy - a systematic review and meta-analysis of clinical trials
Placebo and Nocebo Responses in Multiple System Atrophy - a systematic review and meta-analysis of clinical trials Open
BACKGROUND Multiple System Atrophy (MSA) is a rapidly progressive and fatal neurodegenerative disease, with no effective treatment. Estimating the placebo and nocebo responses will help better design and interpret clinical trials. Objectiv…
View article: Airway clearance management in people with bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Airway clearance management in people with bronchiectasis: data from the European Bronchiectasis Registry (EMBARC) Open
Background International guidelines recommend airway clearance management as one of the important pillars of bronchiectasis treatment. However, the extent to which airway clearance is used for people with bronchiectasis in Europe is unclea…
View article: Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC) Open
Background A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the European Bronchiectasis Registry (EMBARC), we tested whether sputum colour would be…
View article: Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation
Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation Open
Cystic fibrosis is a monogenic disease with a multisystemic phenotype, ranging from predisposition to chronic lung infection and inflammation to reduced bone mass. The exact mechanisms unbalancing the maintenance of an optimal bone mass in…
View article: Lung Auscultation Using the Smartphone—Feasibility Study in Real-World Clinical Practice
Lung Auscultation Using the Smartphone—Feasibility Study in Real-World Clinical Practice Open
Conventional lung auscultation is essential in the management of respiratory diseases. However, detecting adventitious sounds outside medical facilities remains challenging. We assessed the feasibility of lung auscultation using the smartp…
View article: Chronic Bacterial Infection Prevalence, Risk Factors, and Characteristics: A Bronchiectasis Population-Based Prospective Study
Chronic Bacterial Infection Prevalence, Risk Factors, and Characteristics: A Bronchiectasis Population-Based Prospective Study Open
Background: Few data are available on chronic bacterial infections (CBI) in bronchiectasis patients. Given that CBI seems to trigger longer hospital stays, worse outcomes, and morbimortality, this study was undertaken to assess CBI prevale…
View article: Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials
Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials Open
Pulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and are frequently used as an outcome measure in clinical research into chronic lung diseases. So far, there has been no consens…
View article: Cystic fibrosis – Comparison between patients in paediatric and adult age
Cystic fibrosis – Comparison between patients in paediatric and adult age Open
The results suggest that patients with CF diagnosed in childhood have characteristics that distinguish them from those diagnosed in adulthood, and these differences may have implications for diagnosis, prognosis and life expectancy.
View article: Recommendations for aetiological diagnosis of bronchiectasis
Recommendations for aetiological diagnosis of bronchiectasis Open
The number of bronchiectasis diagnoses has increased in the last two decades due to several factors. Research carried out over the last years showed that an aetiological diagnosis could change the approach and treatment of a relevant perce…
View article: Cystic fibrosis – characterization of the adult population in Portugal
Cystic fibrosis – characterization of the adult population in Portugal Open
This study is the first description of the Portuguese adult CF population, which is particularly important since it can give us a better understanding of the real situation. A significant percentage of these patients were diagnosed in adul…