Adeline E. Walsh
YOU?
Author Swipe
View article: APOE genotype modifies microglial immunometabolism
APOE genotype modifies microglial immunometabolism Open
Background Metabolic dysfunction and neuroinflammation characterize Alzheimer’s disease (AD), but it is unclear if these two facets of the disease are linked. The E4 allele of Apolipoprotein E (APOE) is the strongest genetic risk factor fo…
View article: The Alzheimer's disease risk factor <i>INPP5D</i> restricts neuroprotective microglial responses in amyloid beta‐mediated pathology
The Alzheimer's disease risk factor <i>INPP5D</i> restricts neuroprotective microglial responses in amyloid beta‐mediated pathology Open
Introduction Mutations in INPP5D , which encodes for the SH2‐domain‐containing inositol phosphatase SHIP‐1, have recently been linked to an increased risk of developing late‐onset Alzheimer's disease. While INPP5D expression is almost excl…
View article: APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge Open
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bul…
View article: <i>APOE4</i>drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes
<i>APOE4</i>drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes Open
Summary Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor of APOE while also being critical mediators of …
View article: Engineering mighty microglia
Engineering mighty microglia Open
Defective microglial responses underlie many neurological disorders. Recent efforts to swap out dysfunctional microglia with optimized replacements have been derailed by safety issues and transplantation inefficiencies. In this issue, Chad…
View article: <i>APOE</i> modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
<i>APOE</i> modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge Open
Summary The E4 allele of Apolipoprotein E ( APOE ) is associated with both metabolic dysfunction and a heightened pro-inflammatory response – two findings that may be intrinsically linked through the concept of immunometabolism. Here, we c…
View article: APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis Open
View article: Additional file 1 of APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Additional file 1 of APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis Open
Additional file 1. Differentially expressed genes in astrocytes (E4/E4 vs E3/E3).
View article: Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics
Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics Open
Stable isotope-resolved metabolomics (SIRM) is a powerful tool for understanding disease. Advances in SIRM techniques have improved isotopic delivery and expanded the workflow from exclusively in vitro applications to in vivo methodologies…
View article: APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis Open
Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the E4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-ons…
View article: Lipid Droplets in Neurodegenerative Disorders
Lipid Droplets in Neurodegenerative Disorders Open
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular si…
View article: APOE alters glucose flux through central carbon pathways in astrocytes
APOE alters glucose flux through central carbon pathways in astrocytes Open
The Apolipoprotein E (APOE) gene is a major genetic risk factor associated with Alzheimer's disease (AD). APOE encodes for three main isoforms in humans (E2, E3, and E4). Homozygous E4 individuals have more than a 10-fold higher risk for d…