Adeline Mei Hui Yong
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View article: The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis
The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis Open
Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faecalis , the endocarditis and biofilm-associated pilus (Ebp) is polymerized on the membrane by sortase C (SrtC) and attached to the cell wall …
View article: Addressing the safety of new food sources and production systems
Addressing the safety of new food sources and production systems Open
New food sources and production systems (NFPS) are garnering much attention, driven by international trade, changing consumer preferences, potential sustainability benefits, and innovations in climate‐resilient food production systems. How…
View article: The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture
The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture Open
Bacterial lifestyles depend on conditions encountered during colonization. The transition between planktonic and biofilm growth is dependent on the intracellular second messenger c-di-GMP. High c-di-GMP levels driven by diguanylate cyclase…
View article: The HtrA chaperone monitors sortase-assembled pilus biogenesis in<i>Enterococcus faecalis</i>
The HtrA chaperone monitors sortase-assembled pilus biogenesis in<i>Enterococcus faecalis</i> Open
Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faecalis , the endocarditis and biofilm-associated pilus (Ebp) is polymerized on the membrane by sortase C (SrtC) and attached to the cell wall …
View article: Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes
Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes Open
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in…
View article: The novel E. coli cell division protein, YtfB, plays a role in eukaryotic cell adhesion
The novel E. coli cell division protein, YtfB, plays a role in eukaryotic cell adhesion Open
View article: Combined efficacy of a novel antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens
Combined efficacy of a novel antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens Open
Antibiotic-resistant infections are predicted to kill 10 million people worldwide per year by 2050 and to cost the global economy 100 trillion USD. Novel approaches and alternatives to conventional antibiotics are urgently required to comb…
View article: HtrA and CroRS two-component signal transduction system monitor sortase-assembled pilus biogenesis in Enterococcus faecalis
HtrA and CroRS two-component signal transduction system monitor sortase-assembled pilus biogenesis in Enterococcus faecalis Open
Enterococcus faecalis is one of the leading causes of hospital-acquired infections (HAIs). One of the most commonly associated virulence factors in these HAIs is the endocarditis and biofilm-associated pilus (Ebp) which is often implicated…
View article: Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection
Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection Open
Enterococcus faecalis is one of the most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynami…
View article: Model systems for the study of Enterococcal colonization and infection
Model systems for the study of Enterococcal colonization and infection Open
Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the u…