Adeline Sivignon
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View article: Development of a combination of probiotics and plant extracts targeting adherent-invasive Escherichia coli associated with Crohn’s disease
Development of a combination of probiotics and plant extracts targeting adherent-invasive Escherichia coli associated with Crohn’s disease Open
Abnormal colonisation of the ileal mucosa by adherent-invasive Escherichia coli (AIEC) is a key feature of Crohn’s disease. To date, no curative treatment for this disease exists, highlighting the need to develop new therapies targeting th…
View article: Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella
Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive <i>Escherichia coli</i> (AIEC)
ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive <i>Escherichia coli</i> (AIEC) Open
We investigated the role of ChiA and its associated polymorphisms in the interaction between Crohn's disease (CD)-associated adherent-invasive Escherichia coli (AIEC) and intestinal mucosa. We observed a higher abundance of chiA<…
View article: Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella
Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome
Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome Open
View article: Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients
Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients Open
Adherent-invasive Escherichia coli (AIEC), which abnormally colonize the ileal mucosa of Crohn’s disease (CD) patients, are known to contribute to the etiopathogenesis of CD. Molecular mechanisms favoring AIEC ileal colonization have not b…
View article: An adherent-invasive <i>Escherichia coli</i>-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease
An adherent-invasive <i>Escherichia coli</i>-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease Open
Adherent-invasive Escherichia coli (AIEC) were investigated for their involvement in the induction/chronicity of intestinal inflammation in Crohn's disease (CD). AIEC gut establishment is favoured by overexpression of the glycoprotein CEAC…
View article: Beneficial Effects of Linseed Supplementation on Gut Mucosa-Associated Microbiota in a Physically Active Mouse Model of Crohn’s Disease
Beneficial Effects of Linseed Supplementation on Gut Mucosa-Associated Microbiota in a Physically Active Mouse Model of Crohn’s Disease Open
The Western diet, rich in lipids and in n-6 polyunsaturated fatty acids (PUFAs), favors gut dysbiosis observed in Crohn’s disease (CD). The aim of this study was to assess the effects of rebalancing the n-6/n-3 PUFA ratio in CEABAC10 trans…
View article: In Vitro Evaluation of Dietary Fiber Anti-Infectious Properties against Food-Borne Enterotoxigenic Escherichia coli
In Vitro Evaluation of Dietary Fiber Anti-Infectious Properties against Food-Borne Enterotoxigenic Escherichia coli Open
Dietary fibers have well-known beneficial effects on human health, but their anti-infectious properties against human enteric pathogens have been poorly investigated. Enterotoxigenic Escherichia coli (ETEC) is the main agent of travelers’ …
View article: Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease
Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease Open
View article: Heteropolysaccharides from S. cerevisiae show anti-adhesive properties against E. coli associated with Crohn's disease
Heteropolysaccharides from S. cerevisiae show anti-adhesive properties against E. coli associated with Crohn's disease Open
View article: The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli
The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli Open
Gut microbiota dysbiosis toward adherent-invasive Escherichia coli (AIEC) plays an important role in Crohn’s disease (CD). The OmpR transcriptional regulator is required for the AIEC LF82 prototype strain to adhere and invade intestinal ep…
View article: A21 ULCERATIVE COLITIS-ASSOCIATED <i>E. COLI</i> PATHOBIONTS POTENTIATE COLITIS IN SUSCEPTIBEL HOSTS.
A21 ULCERATIVE COLITIS-ASSOCIATED <i>E. COLI</i> PATHOBIONTS POTENTIATE COLITIS IN SUSCEPTIBEL HOSTS. Open
Background Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These “pathobionts” exhibit pathoge…
View article: Ulcerative Colitis-associated <i>E. coli</i> pathobionts potentiate colitis in susceptible hosts
Ulcerative Colitis-associated <i>E. coli</i> pathobionts potentiate colitis in susceptible hosts Open
Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These "pathobionts" exhibit path…
View article: Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn’s disease
Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn’s disease Open
View article: Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic <i>E. coli</i>
Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic <i>E. coli</i> Open
We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains.
View article: Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli
Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli Open
A novel mechanism is revealed by which clinical isolates of adherent-invasive Escherichia coli (AIEC) penetrate into the epithelial cell layer, replicate, and establish biofilms in Crohn's disease. AIEC uses the FimH fimbrial adhesi…
View article: HOW PATHOGENIC BACTERIA PROFIT FROM YOUR STRESS
HOW PATHOGENIC BACTERIA PROFIT FROM YOUR STRESS Open
Crohn’s disease (CD) is a life-long chronic disorder characterized by intestinal infl ammation. Current treatments for CD are directed towards abnormal immune responses rather than the intestinal bacteria that trigger intestinal infl ammatio…
View article: Bacteriophages targeting adherent invasive <i>Escherichia coli</i> strains as a promising new treatment for Crohn's disease
Bacteriophages targeting adherent invasive <i>Escherichia coli</i> strains as a promising new treatment for Crohn's disease Open
These findings demonstrate that bacteriophages are a new treatment option for targeting AIEC in CD patients and represent a strong basis for a clinical trial evaluation.
View article: Differentiation of Crohn’s Disease-Associated Isolates from Other Pathogenic Escherichia coli by Fimbrial Adhesion under Shear Force
Differentiation of Crohn’s Disease-Associated Isolates from Other Pathogenic Escherichia coli by Fimbrial Adhesion under Shear Force Open
Shear force exerted on uropathogenic Escherichia coli adhering to surfaces makes type-1 fimbriae stretch out like springs to catch on to mannosidic receptors. This mechanism is initiated by a disruption of the quaternary interactions betwe…
View article: Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease
Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease Open
The ileal lesions of Crohn's disease (CD) patients are colonized by adherent-invasive Escherichia coli (AIEC) bacteria. These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner. In thi…
View article: Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease
Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease Open
S. cerevisiae yeasts reduce colitis induced by AIEC bacteria in CEACAM6-expressing mice. Such a probiotic strategy could be envisaged in a subgroup of patients with CD abnormally expressing CEACAM6 at the ileal mucosa and therefore suscept…
View article: Brilliant glyconanocapsules for trapping of bacteria
Brilliant glyconanocapsules for trapping of bacteria Open
n-Heptyl α-d-mannose-functionalized nanocapsules are prepared by the Shift'N'Go process and post-modified to ensure aggregation and efficient removal of bacteria.