Adelinn Kalman
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View article: Morphological cell profiling for drug repurposing against SARS-CoV-2 infection
Morphological cell profiling for drug repurposing against SARS-CoV-2 infection Open
Antiviral drug discovery has traditionally focused on targeting viral proteins, while host-directed strategies remain largely underexplored. Here, present a systematic drug repurposing strategy leveraging morphological profiling to identif…
View article: Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing
Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing Open
The COVID-19 pandemic has resulted in millions of deaths and affected socioeconomic structure worldwide and the search for new antivirals and treatments are still ongoing. In the search for new drug targets and to increase our understandin…
View article: Interdisciplinary Study on Drug-Induced-Phospholipidosis of Repurposing Libraries through Machine Learning and Experimental Evaluation in Different Cell Lines
Interdisciplinary Study on Drug-Induced-Phospholipidosis of Repurposing Libraries through Machine Learning and Experimental Evaluation in Different Cell Lines Open
Phospholipidosis (PLD), a cellular adverse effect that is, among others, caused by numerous cationic amphiphilic drugs. Interest is raised within pharma discovery to predict this phenomenon, as it can impact the outcome of phenotypic cellu…
View article: A Systematic Host-Centric Approach to Identifying Repurposed Drugs for Viral Infections
A Systematic Host-Centric Approach to Identifying Repurposed Drugs for Viral Infections Open
View article: Interdisciplinary Study on Drug-Induced-Phospholipidosis of Repurposing Libraries Through Machine Learning and Experimental Evaluation in Different Cell Lines
Interdisciplinary Study on Drug-Induced-Phospholipidosis of Repurposing Libraries Through Machine Learning and Experimental Evaluation in Different Cell Lines Open
View article: Exploring the morphology of the host cell to open new possibilities for drug repurposing in viral infections
Exploring the morphology of the host cell to open new possibilities for drug repurposing in viral infections Open
New approaches are needed to identify novel or repurposed drugs to treat deadly viral infections. Majority of screening methods evaluate the drug activity on a given virus while neglecting the host mechanisms and responses to the virus inf…