Explanipedia

Optimising Urinary Tract CT Scans for Renal Colic: Enhancing Efficiency and Reducing Radiation Open

Abbas Khizar Khoja, Adil Bashir, Haris Shoaib, Sulaiman Hussain, Humera Chaudhary · 2025

Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, or Substrate Metabolism in Barth Syndrome Open

W. Todd Cade, Kathryn L. Bohnert, Linda R. Peterson, Lisa de las Fuentes, Emily Poehlein , et al. · 2025

Barth syndrome (BTHS) is a rare X‐linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac …

A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients Open

Genelle D. Samson, Jose O. Maximo, Eric Nelson, Nina V. Kraguljac, William P. Armstrong , et al. · 2025

Background and Hypothesis Converging evidence from animal and human studies has implicated gamma-aminobutyric acid (GABA)-ergic dysfunction in the pathophysiology of psychosis spectrum disorders. However, little is known about GABA’s role …

Pathobiology and Molecular Pathways Implicated in Osteosarcoma Lung Metastasis: A Scoping Review Open

Adil Bashir, Ayden Ismail, Avenie Mavadia, Aruni Ghose, Saak V. Ovsepian , et al. · 2025

Osteosarcoma (OS) is the most common primary bone malignancy, with lung metastasis being the leading cause of mortality. The metastatic process is driven by complex biological mechanisms, including tumor cell-specific adaptations of growth…

692 Deep Brain Stimulation in Schizophrenia- A Systematic Review Open

J. Sivakumaran, Adil Bashir, G N K Amirthalingam, Kumareshan Sivakumaran, Veronica Phillips · 2025

Aim This ongoing systematic review evaluates the clinical efficacy, safety, and neurobiological mechanisms of Deep Brain Stimulation (DBS) as a therapeutic intervention for Treatment-Resistant Schizophrenia (TRS), focusing on optimal neura…

Changes in glutamate levels in anterior cingulate cortex following 16 weeks of antipsychotic treatment in antipsychotic-naïve first-episode psychosis patients Open

Jose O. Maximo, Eric Nelson, Nina V. Kraguljac, Robert Patton, Adil Bashir , et al. · 2025

Background Previous findings in psychosis have revealed mixed findings on glutamate (Glu) levels in the dorsal anterior cingulate cortex (dACC). Factors such as illness chronicity, methodology, and medication status have impeded a more nua…

A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients Open

Eric Nelson, Nina V. Kraguljac, Adil Bashir, Stacey S. Cofield, Jose O. Maximo , et al. · 2024

Background Previous studies have implicated hippocampal abnormalities in the neuropathology of psychosis spectrum disorders. Reduced hippocampal volume has been reported across all illness stages, and this atrophy has been hypothesized to …

Characteristics of patients with myofascial pain syndrome of the low back Open

Pao‐Feng Tsai, Joseph L. Edison, Chih-Hsuan Wang, Michael W. Gramlich, Kailea Q. Manning , et al. · 2024

The objective of this study is to determine characteristics of patients with myofascial pain syndrome (MPS) of the low back and the degree to which the low back pain in the patients examined can be attributed to MPS. Twenty-five subjects w…

Characteristics of patients with myofascial pain syndrome of the low back Open

Pao‐Feng Tsai, Joseph L. Edison, Chih-Hsuan Wang, Michael W. Gramlich, Kailea Q. Manning , et al. · 2023

Objective Identify characteristics of patients with myofascial pain syndrome (MPS) of the low back. Methods Twenty-five subjects with myofascial trigger point(s) [MTrP(s)] on the low back participated in this cross-sectional study. The loc…

Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift Open

Daniel L. Plotkin, Merlina A. Rodas, Andrew D. Vigotsky, Mason C. McIntosh, Emma Breeze , et al. · 2023

We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Untrained college-aged participants were randomized into HT (n = 18) or SQ (n = …

Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift Open

Daniel L. Plotkin, Merlina A. Rodas, Andrew D. Vigotsky, Mason C. McIntosh, Emma Breeze , et al. · 2023

Purpose We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Methods Untrained college-aged participants were randomized into HT or S…

Feasibility of spinal cord imaging at 7 T using rosette trajectory with magnetization transfer preparation and compressed sensing Open

Sultan Z. Mahmud, Thomas S. Denney, Adil Bashir · 2023

MRI is a valuable diagnostic tool to investigate spinal cord (SC) pathology. SC MRI can benefit from the increased signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) at ultra-high fields such as 7 T. However, SC MRI acquisitions…

A STUDY OF THIAMINE DEFICIENCY IN PATIENTS WITH ACUTE ONSETENCEPHALOPATHY Open

Maleeha Wani, Adil Bashir, Masood Tanvir, Sobia Nisar, Umair Altaf , et al. · 2023

Introduction:Vitamin B1, also known as thiamine, and its crucial role in energy metabolism and proper functioning of the nervous and cardiovascular systems. Thiamine is an essential vitamin that must be obtained through diet since the body…

Harmonized Multisite <span>MRI</span>‐Based Quantification of Human Liver Fat and Stiffness: A Pilot Study Open

Owen Carmichael, Maninder Singh, Adil Bashir, Anne M. Russell, Mark Bolding , et al. · 2023

Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of end‐stage liver disease. NAFLD diagnosis and follow‐up relies on a combination of clinical data, liver imaging, and/or liver biopsy. However, intersite imaging diffe…

Direct activation of the fibroblast growth factor-21 pathway in overweight and obese cats Open

Emily J. Brinker, Taylor J. Towns, Rie Watanabe, Xiaolei Ma, Adil Bashir , et al. · 2023

Introduction Feline obesity is common, afflicting ~25–40% of domestic cats. Obese cats are predisposed to many metabolic dyscrasias, such as insulin resistance, altered blood lipids, and feline hepatic lipidosis. Fibroblast Growth Factor-2…

The emerging postural instability phenotype in idiopathic Parkinson disease Open

Frank M. Skidmore, William S. Monroe, Christopher P. Hurt, Anthony P. Nicholas, Adam Gerstenecker , et al. · 2022

Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations Open

Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Cody T. Haun , et al. · 2022

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men ( n = 15, age: 23 ± 3 years; training exp…

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations Open

Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Cody T. Haun , et al. · 2021

Aim We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular markers. Methods Trained men (n=15, age: 23±3 y; training expe…

Simultaneous Measurement of Perfusion and T2* in Calf Muscle at 7T with Submaximal Exercise using Radial Acquisition Open

Sultan Z. Mahmud, L. Bruce Gladden, Andreas N. Kavazis, Robert W. Motl, Thomas S. Denney , et al. · 2020

Impairments in oxygen delivery and consumption can lead to reduced muscle endurance and physical disability. Perfusion, a measure of microvascular blood flow, provides information on nutrient delivery. T 2 * provides information about rela…

Creatine kinase rate constant in the human heart at 7T with 1D-ISIS/2D CSI localization Open

Adil Bashir, Jianyi Zhang, Thomas S. Denney · 2020

[Formula: see text] method enables acquisition of 31P saturation transfer MRS under partially relaxed conditions and enables 2D-CSI of kf in myocardium. This work enables applications for in vivo CSI imaging of energetics in heart and othe…

Myocardial glucose and fatty acid metabolism is altered and associated with lower cardiac function in young adults with Barth syndrome Open

W. Todd Cade, Richard Laforest, Kathryn L. Bohnert, Dominic N. Reeds, Adam J. Bittel , et al. · 2019

The Emerging Gait Dysfunction Phenotype in Idiopathic Parkinson’s Disease Open

Frank M. Skidmore, William S. Monroe, Christopher P. Hurt, Anthony P. Nicholas, Adam Gerstenecker , et al. · 2019

Objective Severity of motor symptoms in Parkinson’s disease (PD), and rate of change of these symptoms, suggests the existence of disease subgroups. One important PD subgroup is defined by postural instability and gait dysfunction (PIGD), …

Displaced calcaneal fractures, midterm results of the sinus tarsi approach and screw fixation Open

Manzoor Ahmad Halwai, Iftikhar H Wani, Naseemul Gani, Munir Farooq, Gulzar Ahmad Kutchay , et al. · 2019

Background: We present the results of displaced intrarticular calcaneal fractures managed by limited sinus tarsi approach with good clinical and radiological outcome and less number of complications seen with conventional …

Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents, and young adults with Barth syndrome Open

W. Todd Cade, Kathryn L. Bohnert, Linda R. Peterson, Bruce W. Patterson, Adam J. Bittel , et al. · 2019

Barth syndrome (BTHS) is a rare X‐linked condition resulting in abnormal mitochondria, cardioskeletal myopathy, and growth delay; however, the effects of BTHS on substrate metabolism regulation and their relationships with tissue function …

Peak oxygen uptake (VO2peak) across childhood, adolescence and young adulthood in Barth syndrome: Data from cross-sectional and longitudinal studies Open

W. Todd Cade, Kathryn L. Bohnert, Dominic N. Reeds, Linda R. Peterson, Adam J. Bittel , et al. · 2018

In conclusion, VO2peak relative to body weight and fat-free mass demonstrates short- and long-term stability from childhood to young adulthood in BTHS with some variability among individuals.

Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome Open

Adil Bashir, Kathryn L. Bohnert, Dominic N. Reeds, Linda R. Peterson, Adam J. Bittel , et al. · 2017

Barth syndrome ( BTHS ) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BT…

A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study Open

Sophia Airhart, W. Todd Cade, Hui Jiang, Andrew R. Coggan, Susan B. Racette , et al. · 2015

Context: Excessive cardiac long-chain fatty acid (LCFA) metabolism/storage causes cardiomyopathy in animal models of type 2 diabetes. Medium-chain fatty acids (MCFAs) are absorbed and oxidized efficiently. Data in animal models of diabetes…

Absolute Quantification of Human Liver Phosphorus-Containing Metabolites In Vivo Using an Inhomogeneous Spoiling Magnetic Field Gradient Open

Adil Bashir, Robert J. Gropler, Joseph J. H. Ackerman · 2015

The technique offers robust and fast means to localize signal from liver tissue, allows absolute metabolite concentration determination, and avoids problems associated with constant field gradient (linear field variation) localization meth…

In vivo creatine kinase reaction kinetics at rest and stress in type II diabetic rat heart Open

Adil Bashir, Andrew R. Coggan, Robert J. Gropler · 2015

The effects of type II diabetes on cardiac creatine kinase (CK) enzyme activity and/or flux are unknown. We therefore measured steady-state phosphocreatine (PCr) and adenosine triphosphate (ATP) content and forward CK reaction kinetic para…

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