Aditee Deshpande
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View article: <scp>TLR7</scp>/8 Activation in Immune Cells and Muscle by <scp>RNA</scp>‐Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis
<span>TLR7</span>/8 Activation in Immune Cells and Muscle by <span>RNA</span>‐Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis Open
Objective Activation of endosomal toll‐like receptors (TLRs) is one possible driver of inflammation in idiopathic inflammatory myopathies (IIM). We investigated the potential contribution of TLR7 and TLR8 to IIM pathogenesis. Methods Activ…
View article: LP-183 Enpatoran: preclinical evidence supporting glucocorticoid dose reduction and phase II study design in patients with SLE and/or CLE (WILLOW)
LP-183 Enpatoran: preclinical evidence supporting glucocorticoid dose reduction and phase II study design in patients with SLE and/or CLE (WILLOW) Open
Background Aberrant toll-like receptor (TLR) 7/8 activation is thought to be involved in both lupus pathogenesis and glucocorticoid resistance. Enpatoran, a selective and potent dual inhibitor of TLR7/8 that is in development for cutaneous…
View article: 1501 Enpatoran: preclinical evidence supporting glucocorticoid dose reduction and Phase II study design in patients with SLE and/or CLE (WILLOW)
1501 Enpatoran: preclinical evidence supporting glucocorticoid dose reduction and Phase II study design in patients with SLE and/or CLE (WILLOW) Open
Purpose Enpatoran is a potent selective dual inhibitor of toll-like receptor (TLR) 7 and TLR8. Previous studies have shown aberrant activation of TLR7/8 may be involved in systemic lupus erythematosus (SLE) pathogenesis and glucocorticoid …
View article: Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity Open
Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production, which is normally a protective host …