Adith S. Arun
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View article: Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Supplementary Data 1 shows an overview of ctDNA dynamics, treatments, and radiological response measurements per patient.
View article: Leading Cause of Death and Life Expectancy Among US Superagers
Leading Cause of Death and Life Expectancy Among US Superagers Open
Importance: The United States has the largest gap between lifespan and healthspan, highlighting a need to understand how some older adults maintain good health into advanced age. Objective: To describe life expectancy and leading causes of…
View article: A Framework for Interpreting White Blood Cell Counts From Lumbar Punctures in Pediatric Acute Lymphoblastic Leukemia
A Framework for Interpreting White Blood Cell Counts From Lumbar Punctures in Pediatric Acute Lymphoblastic Leukemia Open
In pediatric acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is staged using white blood cell (WBC) counts from lumbar punctures (LPs), microscopy of LP-derived cells, and CNS imaging. CNS staging informs the n…
View article: Comparative Analysis of Long COVID and Post-Vaccination Syndrome: A Cross-Sectional Study of Clinical Symptoms and Machine Learning-Based Differentiation
Comparative Analysis of Long COVID and Post-Vaccination Syndrome: A Cross-Sectional Study of Clinical Symptoms and Machine Learning-Based Differentiation Open
Importance Long COVID is a well-documented post-viral syndrome, while post-vaccination syndrome (PVS) remains poorly characterized. Understanding their similarities and differences is essential for refining diagnostic criteria and developi…
View article: Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID
Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Open
View article: Cause-Specific Mortality Rates Among the US Black Population
Cause-Specific Mortality Rates Among the US Black Population Open
This cross-sectional study examines the specific causes of death associated with the disparities in all-cause mortality between non-Hispanic Black and non-Hispanic White populations, as well as their changes over time.
View article: Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study
Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study Open
Among people with long COVID, those with internal tremors and vibrations had different conditions and symptoms and worse health status compared with others who had long COVID without these symptoms.
View article: Long COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort
Long COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort Open
Despite having tried numerous treatments, participants with long COVID continued to experience an array of health and financial challenges-findings that underscore the failure of the healthcare system to address the medical needs of people…
View article: Endovascular stenting of external iliac vein injury during anterior spine exposure
Endovascular stenting of external iliac vein injury during anterior spine exposure Open
View article: Modeling combination therapies in patient cohorts and cell cultures using correlated drug action
Modeling combination therapies in patient cohorts and cell cultures using correlated drug action Open
Characterizing the effect of combination therapies is vital for treating diseases like cancer. We introduce correlated drug action (CDA), a baseline model for the study of drug combinations in both cell cultures and patient populations, wh…
View article: Epidemiological and Genomics Data for Estimating Cancer Mutation Prevalences
Epidemiological and Genomics Data for Estimating Cancer Mutation Prevalences Open
View article: Epidemiological and Genomics Data for Estimating Cancer Mutation Prevalences
Epidemiological and Genomics Data for Estimating Cancer Mutation Prevalences Open
View article: Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization
Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization Open
Introduction A chronic post-vaccination syndrome (PVS) after covid-19 vaccination has been reported but has yet to be well characterized. Methods We included 241 individuals aged 18 and older who self-reported PVS after covid-19 vaccinatio…
View article: Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty
Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty Open
Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; “IL10-KO”) mouse model. Frailty phenotypes overlap the spectrum of diseases (“laminopathies”) caused by mutations in LMN…
View article: Internal tremors and vibrations in long COVID: a cross-sectional study
Internal tremors and vibrations in long COVID: a cross-sectional study Open
Importance Internal tremors and vibrations symptoms have been described as part of neurologic disorders but not fully described as a part of long COVID. Objective To compare demographics, socioeconomic characteristics, pre-pandemic comorbi…
View article: Supplementary Tables S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Tables S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
The Supplementary Tables file consists of Supplementary Tables 1 to 15 belonging to the manuscript "Metastatic colorectal cancer treatment response evaluation by ultra-deep sequencing of cell-free DNA and matched white blood cells"
View article: Data from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Data from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Purpose:Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis–associated alterations can confound identifica…
View article: Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Supplementary Data 1 shows an overview of ctDNA dynamics, treatments, and radiological response measurements per patient.
View article: Supplementary Figures S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Figures S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
The Supplementary Figures file consists of Supplementary Figures 1 to 15 belonging to the manuscript: "Metastatic colorectal cancer treatment response evaluation by ultra-deep sequencing of cell-free DNA and matched white blood cells"
View article: Supplementary Tables S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Tables S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
The Supplementary Tables file consists of Supplementary Tables 1 to 15 belonging to the manuscript "Metastatic colorectal cancer treatment response evaluation by ultra-deep sequencing of cell-free DNA and matched white blood cells"
View article: Data from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Data from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Purpose:Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis–associated alterations can confound identifica…
View article: Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Data S1 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Supplementary Data 1 shows an overview of ctDNA dynamics, treatments, and radiological response measurements per patient.
View article: Supplementary Figures S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Supplementary Figures S1-S15 from Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
The Supplementary Figures file consists of Supplementary Figures 1 to 15 belonging to the manuscript: "Metastatic colorectal cancer treatment response evaluation by ultra-deep sequencing of cell-free DNA and matched white blood cells"
View article: Native lamin A/C brain proteome and novel partners in a mouse chronic inflammation model of human frailty
Native lamin A/C brain proteome and novel partners in a mouse chronic inflammation model of human frailty Open
Tandem Mass Tag (TMT) proteomicsProtein extracts (40 ug total at 1 ug/ul in 1% SDS) were reduced with 15 uL of 15 mM DTT for 1 hour at 56°C, alkylated by adding 15 uL 100 mM iodoacetamide and incubating in the dark for 30 min, and t…
View article: Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty.
Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty. Open
Tandem Mass Tag (TMT) proteomicsProtein extracts (40 ug total at 1 ug/ul in 1% SDS) were reduced with 15 uL of 15 mM DTT for 1 hour at 56°C, alkylated by adding 15 uL 100 mM iodoacetamide and incubating in the dark for 30 min, and t…
View article: Correlated Drug Action as a Baseline Model for Combination Therapy in Patient Cohorts and Cell Cultures
Correlated Drug Action as a Baseline Model for Combination Therapy in Patient Cohorts and Cell Cultures Open
View article: Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells Open
Purpose: Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis–associated alterations can confound identific…
View article: Detection and characterization of lung cancer using cell-free DNA fragmentomes
Detection and characterization of lung cancer using cell-free DNA fragmentomes Open
View article: The Fermi–Dirac distribution provides a calibrated probabilistic output for binary classifiers
The Fermi–Dirac distribution provides a calibrated probabilistic output for binary classifiers Open
Significance While it would be desirable that the output of binary classification algorithms be the probability that the classification is correct, most algorithms do not provide a method to calculate such a probability. We propose a proba…
View article: Correlated Drug Action as a Baseline Model for Combination Therapy in Patient Cohorts and Cell Cultures
Correlated Drug Action as a Baseline Model for Combination Therapy in Patient Cohorts and Cell Cultures Open
Identifying and characterizing the effect of combination therapies is of paramount importance in various diseases, including cancer. Various competing null models have been proposed to serve as baselines against which to compare the effect…