Aditya Chandru
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View article: Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci
Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci Open
Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening, and therefore, HDACs are…
View article: Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci
Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci Open
Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening and therefore HDACs are g…
View article: KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia Open
Epigenetic histone modifiers are key regulators of cell fate decisions in normal and malignant hematopoiesis. Their enzymatic activities are of particular significance as putative therapeutic targets in leukemia. In contrast, less is known…
View article: The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure Open
View article: Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex
Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex Open
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound repressor proteins to facilitate local histone deacetylation…
View article: Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo Open
View article: Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain
Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain Open
View article: A Tale of Two Epigenetic Protein Pairs: Characterizing the Sin3aTET1 Complex and the Decrotonylation Activity of HDAC1/2
A Tale of Two Epigenetic Protein Pairs: Characterizing the Sin3aTET1 Complex and the Decrotonylation Activity of HDAC1/2 Open
Characterizing the Sin3a-TET1 Complex:\nTET 1 permits active DNA demethylation, promoting a transcriptionally permissible environment by preventing aberrant methylation. Contrastingly, Sin3a is the scaffold-protein central to the eponymous…