Explanipedia

Non-uniform impact of extracellular osmotic variations at subcellular level Open

Pragya Singh, Aditya Mittal · 2025

Osmotic perturbations, towards understanding basic cellular architectures and to alter cellular mechanics for various purposes, are widely utilized in cell biology. While osmotic perturbations are known to alter whole-cell morphology, thei…

Conflict of Interest Disclosure in American Arthroplasty Surgical Literature Open

Robert T. Tisherman, Richard A. Wawrose, Aditya Mittal, Stephen H. Chen, Joseph Chen , et al. · 2024

Exon-Intron Boundary Detection Made Easy by Physicochemical Properties of DNA Open

B. Jayaram, Dinesh C Sharma, Danish Aslam, Kopal Sharma, Aditya Mittal · 2024

Genome architecture in eukaryotes exhibits a high degree of complexity. Amidst the numerous intricacies, the existence of genes as non-continuous stretches composed of exons and introns has garnered significant attention and curiosity amon…

Pleomorphism in Biological Units of Life: Morphological Heterogeneity in Cells Does Not Translate Uniformly to Subcellular Components Open

Pragya Singh, Aditya Mittal · 2024

The interplay of the three-dimensional (3D) distribution of various subcellular components and their interactions are expected to control overall cellular morphology in biology. In this study, we aimed to determine whether the pleomorphy o…

(Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells Open

Firdos, T Pramanik, Prachi Verma, Aditya Mittal · 2024

For glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells in animals, it is believed that ATP generated from glucose metabolism is primarily responsible. However, this ignores two well-established aspects in literature: (a) int…

Secretory Conservation in Insulin Producing Cells: Is There a System-Level Law of Mass Action in Biology? Open

Firdos, Aditya Mittal · 2023

Altered secretion of insulin from pancreatic β-cells can manifest into disorders. For example, a lack of endogenously produced and/or secreted insulin results in Type 1 diabetes (and other associated subtypes). Pancreatic β-cells are the e…

Determining Smallest Path Size of Multiplication Transducers Without a Restricted Digit Set Open

Aditya Mittal, Karthik Mittal · 2023

Directed multiplication transducers are a tool for performing non-decimal base multiplication without an additional conversion to base 10. This allows for faster computation and provides easier visualization depending on the problem at han…

CCDC 2172115: Experimental Crystal Structure Determination Open

Hanuman Singh, Pragya Pragya, Aditya Mittal, V. Haridas · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2172117: Experimental Crystal Structure Determination Open

Hanuman Singh, Pragya Pragya, Aditya Mittal, V. Haridas · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Survival Benefit and Cost-Effectiveness Analysis of a Future Blood-Based Diagnostic Test to Detect Cerebral Aneurysm Formation: A hypothetical modeling study Open

Aditya Mittal, Kamil W. Nowicki, Robert Dembinski, Ali Alattar, Michael M. McDowell , et al. · 2023

IMPORTANCE: Cerebral aneurysms are typically diagnosed incidentally or upon rupture. In this study we aimed to investigate cost-effectiveness of a hypothetical blood-based diagnostic test to detect cerebral aneurysm formation in the US hea…

The Development and Testing of Machine Learning Applications into Genetically-Based Disease Detection Open

Aditya Mittal, Kuan-Chen Wu · 2022

This study uses publicly available gene-expression from peripheral blood mononuclear cells fed into a logistically trained machine learn model to accurately predict the probability of early onset of Multiple Sclerosis by identifying biomar…

Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling Open

Aditya Mittal, Akanksha Chauhan · 2022

Isolated traumatic occipital condyle fractures: Is external cervical orthosis even necessary? Open

Enyinna L. Nwachuku, Confidence Njoku-Austin, Kevin Patel, Austin Anthony, Aditya Mittal , et al. · 2021

Background: Occipital condyle fractures (OCFs) have been reported in up to 4–16% of individuals suffering cervical spine trauma. The current management of OCF fractures relies on a rigid cervical collar for 6 weeks or longer. Here, we calc…

Computed-tomography–associated Radiation Exposure in Children with Craniosynostosis Open

Madeleine K. Bruce, Aditya Mittal, Miles J. Pfaff, Darunee S. Whitt, Lynda L. Flom , et al. · 2021

BACKGROUND: The role of computed tomography (CT) for diagnosis and surgical planning for craniosynostosis (CS) is well-established. Although CT imaging is readily accessible at most hospitals, is relatively inexpensive, and can be performe…

Pain in sickle cell disease: current and potential translational therapies Open

Varun Sagi, Aditya Mittal, Huy Tran, Kalpna Gupta · 2021

External Ventricular Drains: An Overview of Indications, Technique, and Complications Open

Anudeep Yekula, Aditya Mittal, Varun Sagi, Mihir Gupta · 2020

External ventricular drains (EVDs or ventriculostomies) are frequently required for acute management of intracranial hypertension and monitoring intracranial pressure.Patients with ventriculostomies are frequently co-managed by multiple sp…

Squamous cell carcinoma of the scalp causing cortical venous thrombosis and Intraparenchymal hematoma Open

Mihir Gupta, Anudeep Yekula, Varun Sagi, Aditya Mittal, Marc S. Schwartz · 2020

•We present a case of squamous cell carcinoma causing cortical venous thrombosis (CoVT)•This is the first case of an invasive scalp lesion causing CoVT and brain hemorrhage•Some cases of CoVT may be managed conservatively•Recurrent, invasi…

Unique and exclusive peptide signatures directly identify intrinsically disordered proteins from sequences without structural information Open

Aditya Mittal, Anandkumar Madhavjibhai Changani, Sakshi Taparia · 2020

Intrinsically disordered proteins are now widely accepted to play crucial roles in biological functions. Identification of signatures of intrinsic disorder is one of the key steps towards building a proper repertoire for their occurrence i…

Osmotic tolerance of avian erythrocytes to complete hemolysis in solute free water Open

Snigdha Singh, Nisha Ponnappan, Anand Verma, Aditya Mittal · 2019

Mast Cell Neural Interactions in Health and Disease Open

Aditya Mittal, Varun Sagi, Mihir Gupta, Kalpna Gupta · 2019

Mast cells (MCs) are located in the periphery as well as the central nervous system (CNS). Known for sterile inflammation, MCs play a critical role in neuroinflammation, which is facilitated by their close proximity to nerve fibers in the …

Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease Open

Huy Tran, Varun Sagi, Waogwende Leonce Song-Naba, Ying Wang, Aditya Mittal , et al. · 2019

Key Points Chronic morphine treatment leads to decreased survival in control mice, but not in sickle mice. Chronic morphine treatment leads to hyperalgesia in sickle mice, but does not lead to analgesic tolerance.

Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium Open

Huy Tran, Aditya Mittal, Varun Sagi, Kathryn Luk, Aithanh Nguyen , et al. · 2019

Endothelial dysfunction underlies the pathobiology of cerebrovascular disease. Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading…

Diet and gender influence survival of transgenic Berkley sickle cell mice Open

Om Jahagirdar, Aditya Mittal, Waogwende Leonce Song-Naba, Ritu Jha, Stacy Kiven , et al. · 2019

Transcriptomic analysis of gene signatures associated with sickle pain Open

Jinny Paul, Anupam Aich, Juan E. Abrahante, Ying Wang, Rebecca S. LaRue , et al. · 2017

Pain is a hallmark feature of sickle cell disease (SCD). Recurrent and unpredictable acute pain due to vaso-oclussive crises (VOC) is unique to SCD; and can be superimposed on chronic pain. To examine the mechanisms underlying pain in SCD,…

Insights into eukaryotic evolution from transmembrane domain lengths Open

Aditya Mittal, Snigdha Singh · 2017

Biological membranes, comprised of proteins anchored by their trans-membrane domains (TMDs) creating a semi-permeable phase with lipid constituents, serve as ‘checkposts’ for not only intracellular trafficking in eukaryotic cells but also …

edgeR_Treatment_Comparison_Output files Open

Jinny Paul, Anupam Aich, Juan E. Abrahante, Ying Wang, Rebecca S. LaRue , et al. · 2017

This file contains full outputs from edgeR DGE analysis for the comparison between hypoxic and normoxic animals for the "Transcriptomic analysis of gene signatures associated with sickle pain" study.

edgeR_Age_Comparison_Output files Open

Jinny Paul, Anupam Aich, Juan E. Abrahante, Ying Wang, Rebecca S. LaRue , et al. · 2017

This file contains full outputs from edgeR DGE analysis for the age group-based comparisons for the "Transcriptomic analysis of gene signatures associated with sickle pain" study.

Transmembrane Domain Lengths Serve as Signatures of Organismal Complexity and Viral Transport Mechanisms Open

Snigdha Singh, Aditya Mittal · 2016

A statistical anomaly indicates symbiotic origins of eukaryotic membranes Open

Suneyna Bansal, Aditya Mittal · 2015

Compositional analyses of nucleic acids and proteins have shed light on possible origins of living cells. In this work, rigorous compositional analyses of ∼5000 plasma membrane lipid constituents of 273 species in the three life domains (a…

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