Aditya Shreenivas
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View article: Evaluating Clinical Factors Including HPV Clearance on Survival Outcomes in HPV+ Oropharyngeal Carcinoma
Evaluating Clinical Factors Including HPV Clearance on Survival Outcomes in HPV+ Oropharyngeal Carcinoma Open
Background: The relationship between detectable circulating tumor DNA levels and clinical outcome following definitive therapy in patients with human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma has not been well est…
View article: Liquid biopsy- A pivotal test to help navigate clinical decisions at a precision center in India!
Liquid biopsy- A pivotal test to help navigate clinical decisions at a precision center in India! Open
Liquid biopsy, specifically circulating tumor DNA (ctDNA) analysis, has emerged as a transformative tool in precision oncology, providing real-time, minimally invasive characterizations of the tumor and tumor dynamics. While tissue biopsy …
View article: Real-world Monitoring of ctDNA Reliably Predicts Cancer Recurrence and Treatment Efficacy in Patients with Resected Stages I-III Colon Cancer
Real-world Monitoring of ctDNA Reliably Predicts Cancer Recurrence and Treatment Efficacy in Patients with Resected Stages I-III Colon Cancer Open
Objective: In this study, we evaluate the utility of ctDNA analysis in a large cohort of patients for whom ctDNA testing was ordered commercially with real-world application. Summary Background Data: Circulating tumor DNA (ctDNA) has emerg…
View article: Exceptional Response to Immunotherapy-based Treatment in Compound <i>EGFR</i> -Mutated Oligometastatic Pulmonary Sarcomatoid Carcinoma: A Case Report
Exceptional Response to Immunotherapy-based Treatment in Compound <i>EGFR</i> -Mutated Oligometastatic Pulmonary Sarcomatoid Carcinoma: A Case Report Open
Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non–small cell lung cancer (NSCLC) with limited treatment options and poor prognosis. EGFR mutations generally respond to tyrosine kinase inhibitors (TKIs)-based tar…
View article: Precision-directed therapy in salivary duct carcinoma
Precision-directed therapy in salivary duct carcinoma Open
Salivary ductal carcinoma is a rare, aggressive salivary gland carcinoma with poor prognosis and high relapse rate. In recurrent metastatic cases, the median survival is only 5 months. Despite the treatment with multimodal therapeutic stra…
View article: 145P Unveiling the molecular landscape of head and neck cancer: Pathway dysregulations and potential therapeutic targets
145P Unveiling the molecular landscape of head and neck cancer: Pathway dysregulations and potential therapeutic targets Open
View article: 175P Differential impact of increased neoantigen load on PD-L1 positive immune cell infiltrations in comparison to PD-L1 expression on tumor cells
175P Differential impact of increased neoantigen load on PD-L1 positive immune cell infiltrations in comparison to PD-L1 expression on tumor cells Open
View article: 144P Is it time to incorporate next generation sequencing of body fluids for detection of circulating tumor DNA (ctDNA) alterations?
144P Is it time to incorporate next generation sequencing of body fluids for detection of circulating tumor DNA (ctDNA) alterations? Open
View article: Successful Targeting of Somatic <i>VHL</i> Alterations With Belzutifan in Two Cases
Successful Targeting of Somatic <i>VHL</i> Alterations With Belzutifan in Two Cases Open
Clear cell renal cell carcinoma (RCC) is commonly associated with alterations in the VHL tumor suppressor gene, resulting in upregulation of hypoxia-inducible factor pathways. Immune checkpoint inhibitors and vascular endothelial growth fa…
View article: Novel Effective Therapeutic Regimen for Recurrent/Metastatic Head and Neck Squamous Cell Cancer: Concurrent Triple Oral Metronomic Chemotherapy and Immunotherapy
Novel Effective Therapeutic Regimen for Recurrent/Metastatic Head and Neck Squamous Cell Cancer: Concurrent Triple Oral Metronomic Chemotherapy and Immunotherapy Open
View article: Intensity-Modulated Reirradiation Therapy With Nivolumab in Recurrent or Second Primary Head and Neck Squamous Cell Carcinoma
Intensity-Modulated Reirradiation Therapy With Nivolumab in Recurrent or Second Primary Head and Neck Squamous Cell Carcinoma Open
Importance Intensity-modulated radiation therapy (IMRT) reirradiation of nonmetastatic recurrent or second primary head and neck squamous cell carcinoma (HNSCC) results in poor progression-free survival (PFS) and overall survival (OS). Obj…
View article: Type I interferon signaling promotes radioresistance in head and neck cancer
Type I interferon signaling promotes radioresistance in head and neck cancer Open
Despite the promise of concurrent radiotherapy (RT) and immunotherapy in head and neck cancer (HNC), multiple randomized trials of this combination have had disappointing results. To evaluate potential immunologic mechanisms of RT resistan…
View article: Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer
Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer Open
ADORA2A (adenosine A2a receptor) and ADORA2B propagate immunoregulatory signals, including restricting both innate and adaptive immunity, though recent data also suggest a tumor suppressor effect in certain settings. We evaluated the RNA e…
View article: Liquid Biopsy for Detection of Pancreaticobiliary Cancers by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and Their Clusters
Liquid Biopsy for Detection of Pancreaticobiliary Cancers by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and Their Clusters Open
Circulating tumor cells (CTCs) have historically been used for prognostication in oncology. We evaluate the performance of liquid biopsy CTC assay as a diagnostic tool in suspected pancreaticobiliary cancers (PBC). The assay utilizes funct…
View article: Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database
Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database Open
View article: Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture Open
View article: The Efficacy and Safety of Immune Checkpoint Inhibitors in Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis
The Efficacy and Safety of Immune Checkpoint Inhibitors in Adrenocortical Carcinoma: A Systematic Review and Meta-Analysis Open
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of different malignancies. However, their efficacy in advanced adrenocortical carcinoma (ACC) remains uncertain. Thus, we conducted a systematic review and meta-analysis…
View article: Liquid Biopsy for Detection of Pancreaticobiliary Cancers in Suspected Patients by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and their Clusters
Liquid Biopsy for Detection of Pancreaticobiliary Cancers in Suspected Patients by Functional Enrichment and Immunofluorescent Profiling of Circulating Tumor Cells and their Clusters Open
Background Circulating tumor cells (CTCs) have historically been used for prognostication in oncology. We evaluate performance of liquid biopsy CTC assay as a diagnostic tool in suspected pancreaticobiliary cancers. The assay utilises func…
View article: Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture Open
View article: Chemotherapy-free treatment targeting fusions and driver mutations in <i>KRAS</i> wild-type pancreatic ductal adenocarcinoma, a case series
Chemotherapy-free treatment targeting fusions and driver mutations in <i>KRAS</i> wild-type pancreatic ductal adenocarcinoma, a case series Open
Background: KRAS wild-type (WT) pancreatic ductal adenocarcinoma (PDAC) represents a distinct entity with unique biology. The therapeutic impact of matched targeted therapy in these patients in a real-world setting, to date, is less establ…
View article: Characterization of an oligometastatic state in patients with metastatic pancreatic adenocarcinoma undergoing systemic chemotherapy
Characterization of an oligometastatic state in patients with metastatic pancreatic adenocarcinoma undergoing systemic chemotherapy Open
Purpose/Objectives Most patients with pancreatic adenocarcinoma (PDAC) will present with distant metastatic disease at diagnosis. We sought to identify clinical characteristics associated with prolonged overall survival (OS) in patients pr…
View article: ALK fusions in the pan-cancer setting: another tumor-agnostic target?
ALK fusions in the pan-cancer setting: another tumor-agnostic target? Open
Anaplastic lymphoma kinase ( ALK ) alterations (activating mutations, amplifications, and fusions/rearrangements) occur in ~3.3% of cancers. ALK fusions/rearrangements are discerned in >50% of inflammatory myofibroblastic tumors (IMTs) and…
View article: P-219 Non-operative management of localized mismatch repair deficient colon cancer: A real-world perspective
P-219 Non-operative management of localized mismatch repair deficient colon cancer: A real-world perspective Open
View article: Definitive Chemoradiation Associated with Improved Survival Outcomes in Patients with Synchronous Oligometastatic Esophageal Cancer
Definitive Chemoradiation Associated with Improved Survival Outcomes in Patients with Synchronous Oligometastatic Esophageal Cancer Open
Background: The study of oligometastatic esophageal cancer (EC) is relatively new. Preliminary data suggests that more aggressive treatment regimens in select patients may improve survival rates in oligometastatic EC. However, the consensu…
View article: Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia
Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia Open
Activation of apoptosis in malignant cells is an established strategy for controlling cancer and is potentially curative. To assess the impact of concurrently inducing the extrinsic and intrinsic apoptosis-signaling pathways in acute myelo…
View article: Atm Or Chek2 Alterations as Potential Biomarkers of Improved Outcomes with Irinotecan: Real-World Analysis of Advanced Pancreatic Ductal Adenocarcinoma
Atm Or Chek2 Alterations as Potential Biomarkers of Improved Outcomes with Irinotecan: Real-World Analysis of Advanced Pancreatic Ductal Adenocarcinoma Open
View article: Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation
Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation Open
• Pre-clinical head and neck models for identifying mechanisms of resistance to immunotherapy are needed. • This study identifies a critical limitation of PDX models developed from autologously engrafted human stem cells. • Aberrant immune…
View article: Blood and Marrow Transplantation (BMT) within Four Weeks of Sars-Cov-2 Infection Is Associated with Increased Risk of Mortality: A National COVID Cohort Collaborative Study
Blood and Marrow Transplantation (BMT) within Four Weeks of Sars-Cov-2 Infection Is Associated with Increased Risk of Mortality: A National COVID Cohort Collaborative Study Open
Introduction The optimal timing of blood and marrow transplant (BMT) following acute SARS-CoV-2 infection is not known. Currently, the American Society for Transplantation and Cellular Therapy recommends proceeding with BMT in 2-3 weeks po…
View article: Sustained response on sequential anti-FGFR therapy in metastatic gall bladder cancer: a case report and literature review
Sustained response on sequential anti-FGFR therapy in metastatic gall bladder cancer: a case report and literature review Open
View article: Carcinoma of unknown primary: Molecular tumor board‐based therapy
Carcinoma of unknown primary: Molecular tumor board‐based therapy Open
A 36-year-old woman presented to an outside hospital with abdominal pain in July of 2021. A computerized tomography (CT) scan of the abdomen and pelvis showed multiple, hypodense lesions within the left hepatic lobe that were concerning fo…